Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders

Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders

(2020) Anjali Sharma et al.   Science Advances

Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease

(2020) Marius Maximilian Woitok et al.   Cell Death & Disease

Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury

(2020) Rishi Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Inhibiting hepatic gluconeogenesis by chitosan lactate nanoparticles containing CRTC2 siRNA targeted by poly(ethylene glycol)-glycyrrhetinic acid

(2019) Ali Rastegari et al.   Drug Delivery and Translational Research

Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation

(2019) Karina Negron et al.   JOURNAL OF CONTROLLED RELEASE

Hepatocyte-Targeted Delivery of siRNA Polyplex with PEG-Modified Lactosylated Dendrimer/Cyclodextrin Conjugates for Transthyretin-Related Amyloidosis Therapy

(2019) Yuya Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance

(2019) Meiling Wu et al.   BIOMATERIALS

Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification

(2019) Shreffler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

(2018) Anjali Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening

(2018) Patrick Marcellin et al.   LIVER INTERNATIONAL

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

(2018) Yossef Alnasser et al.   MOLECULES

PEGylation of polypropylenimine dendrimers: effects on cytotoxicity, DNA condensation, gene delivery and expression in cancer cells

(2018) Sukrut Somani et al.   Scientific Reports

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates

(2018) Pierpaolo Moscariello et al.   Advanced Science

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

(2017) Fan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

(2017) Carlos A. Sanhueza et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycodendrimers: versatile tools for nanotechnology

(2017) René Roy et al.   Brazilian Journal of Pharmaceutical Sciences

Characterization of polyamidoamino (PAMAM) dendrimers using in-line reversed phase LC electrospray ionization mass spectrometry

(2016) John R. Lloyd et al.   Analytical Methods

Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor

(2016) Xiangang Huang et al.   BIOCONJUGATE CHEMISTRY

Nanoscale effects in dendrimer-mediated targeting of neuroinflammation

(2016) Elizabeth Nance et al.   BIOMATERIALS

ASGPR-Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes

(2016) Marie Monestier et al.   CHEMBIOCHEM

Organizing multivalency in carbohydrate recognition

(2016) Christian Müller et al.   CHEMICAL SOCIETY REVIEWS

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

(2016) Yumin Oh et al.   HEPATOLOGY

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Sticky Patches on Lipid Nanoparticles Enable the Selective Targeting and Killing of Untargetable Cancer Cells

(2016) Michelle Sempkowski et al.   LANGMUIR

Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA

(2016) Rishi Sharma et al.   Nanoscale

Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy

(2016) Yan Guo et al.   PLoS One

Asialoglycoprotein Receptor-Mediated Gene Delivery to Hepatocytes Using Galactosylated Polymers

(2015) Bindu Thapa et al.   BIOMACROMOLECULES

Carbohydrate nanocarriers in biomedical applications: functionalization and construction

(2015) Biao Kang et al.   CHEMICAL SOCIETY REVIEWS

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

(2015) Elizabeth Nance et al.   JOURNAL OF CONTROLLED RELEASE

Structural and functional hepatocyte polarity and liver disease

(2015) Paul Gissen et al.   JOURNAL OF HEPATOLOGY

A galactose-functionalized dendritic siRNA-nanovector to potentiate hepatitis C inhibition in liver cells

(2015) Abirami Lakshminarayanan et al.   Nanoscale

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

A fast track strategy toward highly functionalized dendrimers with different structural layers: an “onion peel approach”

(2015) Rishi Sharma et al.   Polymer Chemistry

A highly versatile convergent/divergent “onion peel” synthetic strategy toward potent multivalent glycodendrimers

(2014) Rishi Sharma et al.   CHEMICAL COMMUNICATIONS

Current Status in the Therapy of Liver Diseases

(2014) Philipp Uhl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

“Onion peel” dendrimers: a straightforward synthetic approach towards highly diversified architectures

(2014) Rishi Sharma et al.   Polymer Chemistry

Design and synthesis of multifunctional traceable dendrimers for visualizing drug delivery

(2014) Anjali Sharma et al.   RSC Advances

Combined A3 Coupling and Click Chemistry Approach for the Synthesis of Dendrimer-Based Biological Tools

(2014) Anjali Sharma et al.   ACS Macro Letters

Biodistribution of Fluorescently Labeled PAMAM Dendrimers in Neonatal Rabbits: Effect of Neuroinflammation

(2013) Wojciech G. Lesniak et al.   MOLECULAR PHARMACEUTICS

Simplifying the synthesis of dendrimers: accelerated approaches

(2012) Marie V. Walter et al.   CHEMICAL SOCIETY REVIEWS

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: A research study

(2012) Jeanine Ward   WORLD JOURNAL OF GASTROENTEROLOGY

N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

(2011) Scott H. Medina et al.   BIOMATERIALS

A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development

(2011) Mariano Severgnini et al.   CYTOTECHNOLOGY

Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day

(2010) Per Antoni et al.   MACROMOLECULES

Characterization of High-Fat, Diet-Induced, Non-alcoholic Steatohepatitis with Fibrosis in Rats

(2009) Zheng-Jie Xu et al.   DIGESTIVE DISEASES AND SCIENCES

Dendrimers and nanomedicine: multivalency in action

(2009) Olivier Rolland et al.   NEW JOURNAL OF CHEMISTRY