Article
Environmental Sciences
Manal M. Hussein, Hussam A. Althagafi, Fahad Alharthi, Ashraf Albrakati, Khalaf F. Alsharif, Abdulrahman Theyab, Rami B. Kassab, Ahmad H. Mufti, Mohammad Algahtani, Atif Abdulwahab A. Oyouni, Roua S. Baty, Ahmed E. Abdel Moneim, Maha S. Lokman
Summary: This study aimed to investigate the therapeutic effects of apigenin on gentamicin-induced nephrotoxicity. The results showed that apigenin administration could alleviate kidney impairments, enhance antioxidant capacity, and suppress renal inflammation and apoptosis. The findings suggest that apigenin treatment may be beneficial in alleviating gentamicin-induced renal impairments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Qijing Wu, Wei Li, Jing Zhao, Wei Sun, Qianqian Yang, Chong Chen, Ping Xia, Jingjing Zhu, Yiceng Zhou, Guoshun Huang, Chen Yong, Min Zheng, Enchao Zhou, Kun Gao
Summary: Apigenin has a protective role against DOX-induced nephrotoxicity without compromising its cytotoxicity in malignant tumors. It may serve as a potential protective agent against renal injury and inflammatory diseases, offering promise in attenuating renal toxicity in cancer patients undergoing DOX treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Jing Li, Runbin Sun, Hui Xu, Guangji Wang
Summary: The study demonstrates that mesoporous silica nanoparticles (MSNs) have substantial effects on hepatic metabolism, with intravenous injection leading to more significant impairments compared to oral administration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nur Elena Zaaba, Sumaya Beegam, Ozaz Elzaki, Javed Yasin, Bilal Mohamed Nemmar, Badreldin H. Ali, Ernest Adeghate, Abderrahim Nemmar
Summary: This study found that alpha-bisabolol (BIS) can protect against cisplatin-induced acute kidney injury (AKI) by reducing inflammation and oxidative stress, indicating its potential as a nephroprotective agent.
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Medicine, Research & Experimental
Chen Yu, Hua Dong, Qingchen Wang, Junzhe Bai, Yan-Ni Li, Juan-Juan Zhao, Jia-Zhu Li
Summary: Danshensu has protective effects against cisplatin-induced nephrotoxicity by improving kidney damage, attenuating abnormal renal function indicators and oxidative stress, activating Nrf2/HO-1, and inhibiting the NF-kappa B pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Xinyi Ma, Yuting Lin, Yingying Liu, Wenjie Li, Jibing He, Miaojie Fang, Dingsheng Lin
Summary: The study evaluated the effects of apigenin on random skin flap survival, showing that high-dose apigenin helped increase flap survival area, microcirculatory flow, SOD activity, and VEGF expression levels while decreasing MDA and pro-inflammatory cytokine levels. These findings suggest the potential usefulness of apigenin in preventing skin flap tissue necrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maryam Melaibari, Huda M. Alkreathy, Ahmed Esmat, Nisreen A. Rajeh, Rasheed A. Shaik, Anwar A. Alghamdi, Aftab Ahmad
Summary: The study examined the anti-fibrotic efficacy of apigenin against CCl4-induced hepatic fibrosis in mice. The results showed that apigenin significantly improved hepatic biomarkers, altered oxidative markers, and decreased inflammatory cytokine levels. Furthermore, apigenin treatment inhibited angiogenic activity. Therefore, apigenin may have potential as a therapeutic agent for hepatic fibrosis.
Article
Environmental Sciences
Ashraf Albrakati
Summary: This study showed that apigenin, a flavonoid, has neuroprotective effects against neural damage caused by MSG in rats. Apigenin increased the activity of acetylcholinesterase and levels of brain monoamines, while decreasing the activity of monoamine oxidase. It also reduced oxidative stress and inflammation, and restored the cytoarchitecture of the brain cortex.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yixi Zhou, Xijing Zhao, Weiping Hu, Fengkai Ruan, Chengyong He, Jiyi Huang, Zhenghong Zuo
Summary: Propylene glycol (PG) has nephrotoxic effects, causing oxidative stress and inflammatory responses. The administration of 1 and 5 g/kg/day PG for 28 days in mice resulted in kidney issues and abnormal blood markers.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Osama Y. Althunibat, Mohammad H. Abukhalil, Saleem H. Aladaileh, Haitham Qaralleh, Wesam Al-Amarat, Manal A. Alfwuaires, Abdulmohsen I. Algefare, Nader Ibrahim Namazi, Sahar J. Melebary, Ahmad O. Babalghith, Carlos Adam Conte-Junior
Summary: Formononetin protects against gentamicin-induced renal damage in rats by exhibiting antioxidant, anti-inflammatory, and antiapoptotic activities and augmenting Nrf2 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Toxicology
F. Sahindokuyucu-Kocasari, Y. Akyol, O. Ozmen, S. B. Erdemli-Kose, S. Garli
Summary: The study showed that apigenin (API) has a protective effect against methotrexate (MTX)-induced liver and kidney toxicity by alleviating oxidative stress and tissue injury markers. It also reduced histopathological alterations, apoptosis, and inflammation caused by MTX.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mehdi Goudarzi, Mojtaba Kalantar, Elahe Sadeghi, Mojtaba Haghi Karamallah, Hadi Kalantar
Summary: The study demonstrated that apigenin can prevent methotrexate-induced hepatotoxicity by increasing antioxidant markers and reducing inflammatory factors.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Michael Lau, Benjamin Sealy, Valery Combes, Marco Morsch, Alfonso E. Garcia-Bennett
Summary: The integrity of the blood-brain barrier (BBB) is crucial for the health of the nervous system. In this study, we found that loading the compound probucol within mesoporous silica particles (MSP) can enhance its antioxidant effects, thereby protecting the function and integrity of brain endothelial cells. Through in vitro and in vivo experiments using zebrafish models, we demonstrated that probucol-loaded MSPs can significantly reduce cellular damage caused by oxidative stress and inflammation, and decrease the permeability of the BBB.
Article
Medicine, Research & Experimental
Saleem H. Aladaileh, Farhan K. Al-Swailmi, Mohammad H. Abukhalil, Ahmad F. Ahmeda, Ayman M. Mahmoud
Summary: This study demonstrated that punicalagin (PUN) can alleviate cisplatin-induced renal oxidative stress, inflammatory response, and cell death, enhance antioxidant defenses, and protect kidney function.