A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid

Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering

(2021) Camille M. Le Gall et al.   BIOCONJUGATE CHEMISTRY

Acquired Resistance to Antibody-Drug Conjugates

(2019) Denis Collins et al.   Cancers

Internal enhancement of DNA damage by a novel bispecific antibody-drug conjugate-like therapeutics via blockage of mTOR and PD-L1 signal pathways in pancreatic cancer

(2019) Rui Cao et al.   Cancer Medicine

Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations

(2019) Roman V. Kholodenko et al.   CURRENT MEDICINAL CHEMISTRY

High antitumor activity of Sortase A-generated anti-CD20 antibody fragment drug conjugates

(2019) Wenhui Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation

(2019) Michael D. Lee et al.   BIOCONJUGATE CHEMISTRY

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

(2018) James W. Purcell et al.   CANCER RESEARCH

Therapeutic application of antibody fragments in autoimmune diseases: current state and prospects

(2018) João C. Fernandes   DRUG DISCOVERY TODAY

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

(2018) Karolina Świderska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps

(2018) Kenneth R. Durbin et al.   MOLECULAR CANCER THERAPEUTICS

Challenges of site-specific selenocysteine incorporation into proteins by Escherichia coli

(2018) Xian Fu et al.   RNA Biology

Progressively Enlarging Cerebellar Hematoma Concurrent with T-DM1 Treatment

(2018) Marcelo D. Vilela et al.   World Neurosurgery

Small Unnatural Amino Acid Carried Raman Tag for Molecular Imaging of Genetically Targeted Proteins

(2018) Jing Zhang et al.   Journal of Physical Chemistry Letters

Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads

(2018) Amit Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes

(2018) Meghdad Abdollahpour-Alitappeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Site-Specific Photolabeling of the IgG Fab Fragment Using a Small Protein G Derived Domain

(2016) Sara Kanje et al.   BIOCONJUGATE CHEMISTRY

One-Step Conjugation Method for Site-Specific Antibody–Drug Conjugates through Reactive Cysteine-Engineered Antibodies

(2016) Daisuke Shinmi et al.   BIOCONJUGATE CHEMISTRY

Mechanisms of Resistance to Antibody–Drug Conjugates

(2016) Frank Loganzo et al.   MOLECULAR CANCER THERAPEUTICS

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues

(2015) Xiuling Li et al.   BIOCONJUGATE CHEMISTRY

Identification of Highly Reactive Cysteine Residues at Less Exposed Positions in the Fab Constant Region for Site-Specific Conjugation

(2015) Yasuhisa Shiraishi et al.   BIOCONJUGATE CHEMISTRY

Influence of molecular size on tissue distribution of antibody fragments

(2015) Zhe Li et al.   mAbs

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

(2014) John M. Lambert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle

(2014) Kathy Zhang et al.   mAbs

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Genetic Incorporation of Multiple Unnatural Amino Acids into Proteins in Mammalian Cells

(2013) Han Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites

(2012) Kiyoshi Ozawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli

(2012) A. Chatterjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

(2011) John B. Jordan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

(2010) Y. V. Kovtun et al.   CANCER RESEARCH

Applications of single-chain variable fragment antibodies in therapeutics and diagnostics

(2009) Nina E. Weisser et al.   BIOTECHNOLOGY ADVANCES

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY