Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes

Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases

(2021) Shyam R. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of a concerted vs. sequential oxygen activation mechanism in α-ketoglutarate–dependent nonheme ferrous enzymes

(2020) Serra Goudarzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeIV═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction

(2020) Martin Srnec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes

(2018) Andrew J. Jasniewski et al.   CHEMICAL REVIEWS

NRVS Studies of the Peroxide Shunt Intermediate in a Rieske Dioxygenase and Its Relation to the Native FeII O2 Reaction

(2018) Kyle D. Sutherlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Distinct Mechanisms for C–C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

(2018) Noah P. Dunham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O2 Activation by Nonheme FeII α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH

(2018) Shyam R. Iyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectroscopic and Electronic Structure Study of ETHE1: Elucidating the Factors Influencing Sulfur Oxidation and Oxygenation in Mononuclear Nonheme Iron Enzymes

(2018) Serra Goudarzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear Resonance Vibrational Spectroscopy Definition of O2 Intermediates in an Extradiol Dioxygenase: Correlation to Crystallography and Reactivity

(2018) Kyle D. Sutherlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase

(2017) Andrew J. Mitchell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Frontier Molecular Orbital Contributions to Chlorination versus Hydroxylation Selectivity in the Non-Heme Iron Halogenase SyrB2

(2017) Martin Srnec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O2 Activation by Non-Heme Iron Enzymes

(2016) Edward I. Solomon et al.   BIOCHEMISTRY

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

(2016) Anna J. Komor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectroscopic Evidence for the Two C–H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

(2016) Esta Tamanaha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

(2016) Martin Srnec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Structural Insights into Cytochrome P450 Function

(2016) F. Peter Guengerich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase

(2015) Brent S. Rivard et al.   BIOCHEMISTRY

Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

(2015) Salette Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases

(2014) Hanna Tarhonskaya et al.   BIOCHEMISTRY

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Geometric and Electronic Structure Contributions to Function in Non-heme Iron Enzymes

(2013) Edward I. Solomon et al.   ACCOUNTS OF CHEMICAL RESEARCH

A new model for allosteric regulation of phenylalanine hydroxylase: Implications for disease and therapeutics

(2013) Eileen K. Jaffe et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Kinetic Mechanism of Phenylalanine Hydroxylase: Intrinsic Binding and Rate Constants from Single-Turnover Experiments

(2013) Kenneth M. Roberts et al.   BIOCHEMISTRY

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

(2013) Sarah M. Barry et al.   ACS Catalysis

Ring-Cleaving Dioxygenases with a Cupin Fold

(2012) Susanne Fetzner   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of Patient Mutations in Human Persulfide Dioxygenase (ETHE1) Involved in H2S Catabolism

(2012) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Frontier molecular orbitals in S = 2 ferryl species and elucidation of their contributions to reactivity

(2012) M. Srnec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Resonance Vibrational Spectroscopy on the FeIVO S=2 Non-Heme Site in TMG3tren: Experimentally Calibrated Insights into Reactivity

(2011) Shaun D. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evidence for a High-Spin Fe(IV) Species in the Catalytic Cycle of a Bacterial Phenylalanine Hydroxylase

(2011) Aram Joel Panay et al.   BIOCHEMISTRY

X-ray Absorption Spectroscopy Structural Investigation of Early Intermediates in the Mechanism of DNA Repair by Human ABH2

(2011) Nitai Charan Giri et al.   BIOCHEMISTRY

Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases

(2010) Jorge Alex Pavon et al.   BIOCHEMISTRY

The Crystal Structure of a High-Spin Oxoiron(IV) Complex and Characterization of Its Self-Decay Pathway

(2010) Jason England et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

(2010) L. V. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Combined NRVS and DFT Study of FeIVO Model Complexes: A Diagnostic Method for the Elucidation of Non-Heme Iron Enzyme Intermediates

(2008) Caleb B. Bell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of extradiol aromatic ring-cleaving dioxygenases

(2008) John D Lipscomb   CURRENT OPINION IN STRUCTURAL BIOLOGY