Article
Chemistry, Multidisciplinary
Hong-jin Wang, Hai-feng Ran, Yue Yin, Xiao-gang Xu, Bao-xiang Jiang, Shi-qi Yu, Yi-jin Chen, Hui-jing Ren, Shan Feng, Ji-fen Zhang, Yi Chen, Qiang Xue, Xiao-yu Xu
Summary: In this study, it was found that catalpol can protect the NVU in ischemic stroke by activating the PI3K/AKT signaling pathway and increasing VEGF production, which subsequently enhances angiogenesis and neurogenesis. This protective mechanism forms a feed-forward loop to safeguard the NVU from the effects of ischemic stroke.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Shin-Young Park, Min-Jeong Kang, Nuri Jin, So Young Lee, Yun Young Lee, Sungsin Jo, Jeong Yun Eom, Heejae Han, Sook In Chung, Kiseok Jang, Tae-Hwan Kim, Jungwon Park, Joong-Soo Han
Summary: House dust mite allergens induce CCL20 expression, leading to chronic inflammation and airway remodeling in a mouse model of asthma.
Article
Endocrinology & Metabolism
Andrew M. N. Walker, Nele Warmke, Ben Mercer, Nicole T. Watt, Romana Mughal, Jessica Smith, Stacey Galloway, Natalie J. Haywood, Taha Soomro, Kathryn J. Griffin, Stephen B. Wheatcroft, Nadira Y. Yuldasheva, David J. Beech, Peter Carmeliet, Mark T. Kearney, Richard M. Cubbon
Summary: Endothelial insulin receptors play a crucial role in promoting angiogenesis and functional response to vascular endothelial growth factor A (VEGF-A). Deficiency of Insr can impair the response to VEGF-A, affecting the angiogenic process.
Article
Integrative & Complementary Medicine
Li Yan, Ge Jing-Ping, Ma Ke, Yin Yuan-Yuan, He Juan, Gu Jian-Ping
Summary: The combination of EGCG and warfarin can reduce the weight and length of thrombus and prevent apoptosis in HUVECs by inhibiting inflammation via the PI3K/AKT and ERK1/2 signaling pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Lei Fang, Ming Zhang, Junling Li, Liang Zhou, Michael Tamm, Michael Roth
Summary: Cigarette smoke induces the deterioration of airway smooth muscle cells (ASMCs) in chronic obstructive pulmonary disease (COPD), leading to tissue loss and structural remodeling of the bronchi. The study found that COPD ASMCs showed decreased expression of collagen type-I and alpha-smooth muscle actin (alpha-SMA), but increased levels of fibronectin. Cigarette smoke extract (CSE) further downregulated collagen type-I and alpha-SMA expression, but upregulated fibronectin. CSE-induced mitophagy and lysosome activity were mediated by ERK1/2 phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi, Yue Wang
Summary: In this study, it was found that VEGF-A enhances the cytotoxicity of CD4 CTLs through the VEGF-R1/VEGF-R2/AKT/mTOR pathway. These findings provide insights for the development of novel treatments for disorders associated with CD4 CTLs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jirapak Ruttanapattanakul, Nitwara Wikan, Siriporn Okonogi, Mingkwan Na Takuathung, Pensiri Buacheen, Pornsiri Pitchakarn, Saranyapin Potikanond, Wutigri Nimlamool
Summary: Boesenbergia rotunda extract promotes wound healing by stimulating cell proliferation, activating the ERK1/2 and Akt signaling pathways, but does not enhance cell migration. These findings support the potential of BR as a wound-healing promoting agent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anuradha Kirtonia, Amit Kumar Pandey, Balaji Ramachandran, Durga Prasad Mishra, David W. Dawson, Gautam Sethi, Trivadi S. Ganesan, H. Phillip Koeffler, Manoj Garg
Summary: LAMC2 plays a crucial role in the tumorigenesis of PDAC by repressing epithelial-mesenchymal transition and modulating the EGFR/ERK1/2/AKT/mTOR axis, thus inhibiting PDAC tumor growth and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Developmental Biology
Colin J. Dinsmore, Philippe Soriano
Summary: Understanding how cells activate intracellular signaling pathways in response to external signals is an important goal in cell and developmental biology. Live-cell signaling reporters have greatly contributed to our understanding of signaling dynamics. Translocation reporters have received attention due to their ease of use and fast response times. This study created two new mouse reporter lines to investigate the ERK1/2 and AKT signaling pathways.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Yuxiang Song, Kexin Wang, Juan J. Loor, Qianming Jiang, Yuchen Yang, Shang Jiang, Siyuan Liu, Jiyuan He, Xiancheng Feng, Xiliang Du, Lin Lei, Wenwen Gao, Guowen Liu, Xinwei Li
Summary: This study investigated the effects of BHB on neutrophil apoptosis and the underlying regulatory mechanisms during ketosis. The results showed that high concentrations of BHB inhibit apoptosis in bovine neutrophils by activating the ERK1/2 and AKT signaling pathways. These findings have important implications for understanding systemic inflammation in ketotic cows.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Oncology
Aurimas Stulpinas, Matas Sereika, Aida Vitkeviciene, Ausra Imbrasaite, Natalija Krestnikova, Audrone V. V. Kalvelyte
Summary: Cell signaling manipulation is crucial for anticancer therapy, and the cell state determines the response to drugs. Therefore, understanding the relationship between cell state and therapeutic sensitivity is essential for the development of cancer treatments. Patient-derived ex vivo cell models show promise in translating research findings into clinical applications in the era of personalized medicine.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jinjun Wu, Muyan Kong, Yanmei Lou, Leyan Li, Chunlin Yang, Huifang Xu, Yuqi Cui, Hong Hao, Zhenguo Liu
Summary: This study found that FMNT significantly enhances endothelial function and promotes angiogenesis through activating Erk1/2- and Akt-mediated eNOS/NO signaling pathway. Simultaneous activation of Erk1/2 and Akt signaling is required for FMNT-induced promotion of endothelial function, providing evidence for potential clinical applications in conditions related to vascular insufficiency.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Radhika Adhikari, Jaehun Jung, Saugat Shiwakoti, Eun-Young Park, Hyun-Jung Kim, Ju-Young Ko, Jaeyoon You, Minho Lee, Min -Ho Oak
Summary: Calcific aortic valve stenosis (CAVS), the third most prevalent cardiovascular disorder, imposes a significant burden on patients but lacks pharmaceutical treatment options. Aortic valve replacement is the only option, but its effectiveness is uncertain and complications are common. Capsaicin, known for its anti-inflammatory and antioxidant properties, has been found to inhibit arterial calcification. In this study, capsaicin was shown to reduce calcium deposition in calcified aortic valve interstitial cells (VICs) and downregulate calcification markers, suggesting its potential as a treatment for CAVS. The mechanism of action involves inhibition of the NF kappa B/AKT/ERK1/2 signaling pathway, oxidative stress, and AGE-RAGE signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Haiying Peng, Fei Sun, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Anli Zuo, Degan Lu
Summary: Sema7a is overexpressed in asthmatics, and its expression in lung tissue can be induced by TGF-beta 1. Integrin-beta 1 plays a crucial role in TGF-beta 1-mediated EMT in human bronchial epithelial cells. Inhibition of the interaction between Sema7a and Integrin-beta 1 can suppress EMT, proliferation, and migration of HBECs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Xue Wei, Jing Wang, Yu-Ying Deng, Bing-Hao Shao, Ze-Feng Zhang, Hui-Hui Wang, Chun -Mei Wang
Summary: The application of Tubechong patching therapy can promote fracture healing in rats by regulating angiogenesis through the VEGF/ERK1/2 signaling pathway. It has been found to have the potential to promote cell proliferation, migration, and wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)