Article
Geriatrics & Gerontology
Rachana Trivedi, Bailey Knopf, Jitendra Kumar Tripathi, Shar Rakoczy, Gunjan D. Manocha, Holly Brown-Borg, Donald A. Jurivich
Summary: Aging leads to changes in the heat shock axis, with old dwarf mice showing preserved and enhanced activating elements compared to old wild-type mice. This suggests that exceptional longevity may be associated with compensatory and enhanced HSF1 regulation in response to age-dependent forces that downregulate the heat shock axis.
Article
Medicine, General & Internal
Alessandro P. Delitala, Angelo Scuteri, Edoardo Fiorillo, Valeria Orru, Edward G. Lakatta, David Schlessinger, Francesco Cucca
Summary: This study found that FT4 levels are positively associated with arterial stiffness at the level of the common carotid artery, with heart rate also playing a role in this relationship.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Joseph M. Dhahbi, Joe W. Chen, Supriya Bhupathy, Hani Atamna, Marcelo B. Cavalcante, Tatiana D. Saccon, Allancer D. C. Nunes, Jeffrey B. Mason, Augusto Schneider, Michal M. Masternak
Summary: This study identified unique responses in ovarian tissues regarding aging and dwarfism, with specific tRF-piRNAs potentially targeting and decreasing the expression of BCAR3 gene, and certain piLRNAs potentially de-repressing transposable elements to have a beneficial impact on ovarian aging in df/df mice. The findings highlight the complexity of aging effects on gene expression and suggest that piRNAs, piLRNAs, tRF-piRNAs, and their targets could play crucial roles in maintaining a younger ovarian phenotype in df/df mice, in addition to miRNAs.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Cristina Arrizabalaga-Arriazu, Borja Martinez-Tellez, Andrea Mendez-Gutierrez, Manuel Munoz-Torres, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: The study found that cold exposure led to an increase in FT4 levels and a decrease in TSH levels, but had no effect on FT3 serum concentration. There were no associations between TSH and THs levels at thermoneutral or cold-induced conditions and BAT volume, F-18-FDG uptake, and mean radiodensity in young healthy euthyroid adults.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
H. W. Vesper, K. Van Uytfanghe, A. Hishinuma, V. Raverot, M. M. Patru, U. Danilenko, A. E. van Herwaarden, E. Shimizu
Summary: The IFCC C-STFT is working on standardizing TSH and FT4 measurements through the establishment of reference systems and implementation activities. Collaborations with organizations in the U.S. and Japan have led to successful initiatives in standardization and harmonization of thyroid function tests. Continuous efforts are being made to improve FT4 and TSH measurements through collaborations with various stakeholders.
CLINICA CHIMICA ACTA
(2021)
Review
Endocrinology & Metabolism
Federico Salas-Lucia, Antonio C. Bianco
Summary: The study indicates that serum T3 levels can accurately predict tissue T3 content and T3 signaling in most tissues, which is of great importance for managing patients with hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Valerie Anne Galton, Arturo Hernandez
Summary: This article explores the importance of thyroid hormone metabolism and its role in maintaining hormone balance, emphasizing that thyroid hormone metabolism is not solely for degradation and elimination but plays a crucial role in regulating various organs and tissues.
Article
Geriatrics & Gerontology
Rachana Trivedi, Bailey Knopf, Sharlene Rakoczy, Gunjan D. Manocha, Holly Brown-Borg, Donald A. Jurivich
Summary: Brain aging is a significant risk factor for cognitive diseases, but exceptional longevity may enhance stress responses. Normal aging has a negative impact on the activation of the brain's heat shock axis, while exceptional aging preserves and strengthens the stress response in the brain.
Article
Nutrition & Dietetics
Hui Wang, Hai-Jun Wang, Mingyuan Jiao, Na Han, Jinhui Xu, Heling Bao, Zheng Liu, Yuelong Ji
Summary: This study found that there were associations between Vitamin D status and thyroid function parameters during pregnancy. Maintaining adequate levels of Vitamin D is crucial for optimal thyroid function during pregnancy.
Article
Endocrinology & Metabolism
Anish D. Bagga, Brian P. Johnson, Qiang Zhang
Summary: In this study, a physiologically based kinetic (PBK) model of thyroid hormones (THs) was constructed to investigate the effects of TH binding proteins (THBPs) and endocrine-disrupting chemicals (EDCs). The model accurately describes the production, distribution, and metabolism of THs, and provides novel insights such as fast blood-tissue exchanges and the limitation of tissue influx in the presence of THBPs. Continuous exposure to THBP-binding EDCs does not alter steady-state TH levels, while intermittent exposure to TBG-binding EDCs can cause greater disruptions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcio Henrique Mello da Luz, Jessica Monteiro Volejnik Pino, Marcos Monico-Neto, Priscila Nicolicht de Amorim, Hanna Karen Moreira Antunes, Marimelia Aparecida Porcionatto, Kil Sun Lee
Summary: Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of A beta protein, which is influenced by APOE genotype and expression, as well as sleep homeostasis. This study demonstrates that hormonal alteration caused by sleep deprivation affects APOE and its receptors, and different cell types play a role in A beta clearance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Patricia Gerhardt, Sabine Begall, Caroline Fraedrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Koehrle, Eddy Rijntjes, Yoshiyuki Henning
Summary: African mole-rats have adapted to the challenges of living underground by evolving low basal metabolism and body temperature. Their unique thyroid hormone phenotype and adaptations to the subterranean habitat were studied by comparing two mole-rat species with the house mouse as a laboratory model. Surprisingly, despite species-specific differences, both mole-rat species showed similar serum thyroid hormone concentrations. This study provides important insights into understanding adaptations to the subterranean habitat.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Klara Gustin, Malin Barman, Helena Skroder, Bo Jacobsson, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Marie Vahter, Maria Kippler
Summary: The study found that exposure to cadmium and mercury during pregnancy may affect thyroid function independently of iodine and selenium levels. Bayesian kernel machine regression did not indicate any mixture effect of toxic metals or interactions between metals and iodine or selenium.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Obstetrics & Gynecology
Yujun Liu, Michal M. Masternak, Augusto Schneider, Xu Zhi
Summary: Dwarf mice have unique characteristics such as long lifespan, delayed ovarian aging, altered metabolism, lower oxidative damage, and lower cancer incidence rate. They are commonly used models to study aging and metabolism. In addition to these aspects, the reproductive features of female dwarf mice have also attracted interest. This review summarizes the research progress on dwarf mice as models in the field of reproductive aging, highlighting their larger ovarian reserve and delayed ovarian aging compared to normal mice, as well as distinctive gene expression patterns.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Geriatrics & Gerontology
Silvana Sidhom, Augusto Schneider, Yimin Fang, Samuel McFadden, Justin Darcy, Roshini Sathiaseelan, Allyson K. Palmer, Frederik J. Steyn, Johannes Grillari, John J. Kopchick, Andrzej Bartke, Shadab Siddiqi, Michal M. Masternak, Michael B. Stout
Summary: 17α-estradiol has been shown to promote health benefits in male mice by increasing hepatic insulin-like growth factor 1 (IGF1) production in a growth hormone (GH)-dependent manner. However, this effect was not observed in female mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Andrzej Bartke
Summary: Growth hormone plays a crucial role in growth, metabolism, and body composition, with a lack of GH leading to slower growth, delayed maturation, and reduced body size. The mechanistic links between GH and aging involve evolutionarily conserved signaling pathways that balance anabolic/growth processes and longevity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Editorial Material
Multidisciplinary Sciences
Cristal M. Hill, Matt Kaeberlein
Summary: Two animal studies suggest that restricting dietary intake of branched-chain amino acids can extend lifespan by modulating the mTOR signalling pathway. However, further research is needed before this diet can be recommended for humans.
Article
Nutrition & Dietetics
William O. Jonsson, Nicholas S. Margolies, Emily T. Mirek, Qian Zhang, Melissa A. Linden, Cristal M. Hill, Christopher Link, Nazmin Bithi, Brian Zalma, Jordan L. Levy, Ashley P. Pettit, Joshua W. Miller, Christopher Hine, Christopher D. Morrison, Thomas W. Gettys, Benjamin F. Miller, Karyn L. Hamilton, Ronald C. Wek, Tracy G. Anthony
Summary: The study investigated the role of ATF4 as a converging point in the integrated stress response during dietary sulfur amino acid restriction (SAAR). The results showed that ATF4 is essential for the sustained production of endogenous hydrogen sulfide and also plays a role in inducing hepatokine fibroblast growth factor 21. Additionally, biological sex was found to be a determinant of the response to dietary SAAR independent of ATF4 status.
JOURNAL OF NUTRITION
(2021)
Article
Geriatrics & Gerontology
Tatiana D. Saccon, Monique T. Rovani, Driele N. Garcia, Jorgea Pradiee, Rafael G. Mondadori, Luis Augusto X. Cruz, Carlos C. Barros, Yimin Fang, Samuel McFadden, Jeffrey B. Mason, Andrzej Bartke, Michal M. Masternak, Augusto Schneider
Summary: The study indicates that growth hormone plays an important role in ovarian reserve in mice, with GH-deficient mice showing reduced DNA double-strand breaks and GH treatment leading to an increase in DNA breaks. Conversely, transgenic mice with excessive GH exhibit significantly increased macrophage infiltration in ovarian tissue.
Article
Geriatrics & Gerontology
Augusto Schneider, Berta Victoria, Maria Isabel Schiavon Cousen, Yimin Fang, Samuel McFadden, Justin Darcy, Adam Gesing, Erin R. Hascup, Kevin N. Hascup, Andrzej Bartke, Michal M. Masternak
Summary: The expression profile of different adipose tissue depots in GHRKO mice is affected by environmental temperature, with brown adipose tissue (BAT) being the most responsive. BAT Ucp1 and Ucp3 expression decreases under thermoneutral conditions in both normal (N) and GHRKO mice. In contrast, subcutaneous white adipose tissue (sWAT) shows the most divergent response to thermoneutrality in GHRKO mice compared to N mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cell Biology
Yun Zhu, Yimin Fang, David Medina, Andrzej Bartke, Rong Yuan
Summary: Research suggests that early metformin treatment can have effects on development and metabolism in mice, including delayed sexual maturation in females, increased body weight and food consumption, increased tail length and IGF1 levels. Metformin alters insulin and insulin sensitivity in a sex-specific manner in mice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Editorial Material
Geriatrics & Gerontology
Michaela E. Murphy, Akilavalli Narasimhan, Alexis Adrian, Ankur Kumar, Cara L. Green, Carolina Soto-Palma, Chathurika Henpita, Christina Camell, Christopher S. Morrow, Chung-Yang Yeh, Claire E. Richardson, Cristal M. Hill, Darcie L. Moore, Dudley W. Lamming, Eric R. McGregor, Heather A. Simmons, Heidi H. Pak, Hua Bai, John M. Denu, Josef Clark, Judith Simcox, Kishore Chittimalli, Korbyn Dahlquist, Kyoo-a Lee, Mariah Calubag, Mark Bouska, Matthew J. Yousefzadeh, Michelle Sonsalla, Reji Babygirija, Rong Yuan, Tadataka Tsuji, Timothy Rhoads, Vinal Menon, Yagna PR. Jarajapu, Yun Zhu
Article
Geriatrics & Gerontology
Samuel McFadden, Lindsey N. Sime, MaKayla F. Cox, Caleigh A. Findley, Mackenzie R. Peck, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R. Hascup, Kevin N. Hascup
Summary: Metabolic dysfunction increases with age and is a contributing factor to Alzheimer's disease (AD) development. In a study on AD mice, it was found that insulin sensitivity and glucose homeostasis were impaired, but could be partially improved by exposure to mild hypothermic environmental temperature. However, glucose tolerance remained impaired and there were additional sexually dimorphic mechanisms that may contribute to the glucose dysregulation in AD mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Yimin Fang, David Medina, Robert Stockwell, Samuel McFadden, Erin R. Hascup, Kevin N. Hascup, Andrzej Bartke
Summary: GHR-KO mice have enhanced resistance to cold stress, but male GHR-KO mice have shortened lifespan in cold environment compared to females. Female GHR-KO and wild-type mice show higher resistance to cold stress than males.
Article
Geriatrics & Gerontology
Yimin Fang, David Medina, Robert Stockwell, Sam McFadden, Kathleen Quinn, Mackenzie R. Peck, Andrzej Bartke, Kevin N. Hascup, Erin R. Hascup
Summary: Senolytic treatment in aged mice clears senescent cell burden leading to functional improvements, but less is known about the effects when administered prior to significant senescent cell accumulation.
Review
Andrology
Andrzej Bartke, Erin Hascup, Kevin Hascup
Summary: There is growing recognition that sex differences extend beyond reproductive organs and traits related to reproduction, and that sex is a significant biological variable in most characteristics of living organisms. This article focuses on sex differences in responses to anti-aging interventions, which have been shown to vary substantially between females and males. While calorie restriction and certain genetic alterations can extend longevity in both sexes, specific metabolic changes and health benefits differ between women and men. It is clear that understanding the unique mechanisms of aging in females and males is crucial for developing effective and tailored anti-aging interventions.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Cell & Tissue Engineering
Andrzej Bartke
Summary: Research on the biology of aging has shifted focus from studying the effects of aging to searching for mechanisms and interventions that can extend healthspan. The field emphasizes multiple physiological changes, nutrient-dependent signaling pathways, and the impact of age as a risk factor for chronic disease. Major advancements in technology and analysis have provided optimism for the development of safe and widely applicable anti-aging interventions in the near future.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Andrology
Andrzej Bartke, Erin Hascup, Kevin Hascup, Michal M. Masternak
Summary: The complex relationships between growth hormone signaling and mammalian aging are attracting attention, with recent studies showing different impacts of GH on genome maintenance and DNA methylation. GH affects white and brown adipose tissue, influencing lipolysis, fibrosis, and thermogenesis, showing mechanistic links to healthspan and lifespan. Studies on GH deficiency in human subjects and mice provide insights into the mechanisms by which GH influences aging and longevity.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Andrzej Bartke, Savannah Brannan, Erin Hascup, Kevin Hascup, Justin Darcy
Summary: Aging is strongly related to energy metabolism, with evidence showing that restricting energy intake and reducing metabolic rate can slow aging and extend longevity. However, increased energy expenditure has also been associated with improved health and longer life. Recent findings on increasing energy expenditure for thermogenesis have shown potential benefits for preventing obesity, improving metabolic health, and extending lifespan.
WORLD JOURNAL OF MENS HEALTH
(2021)