Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling

Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children

(2021) Laurens F. M. Verscheijden et al.   PLoS Computational Biology

Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression

(2020) L. F. M. Verscheijden et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Physiologically-based pharmacokinetic models for children: Starting to reach maturation?

(2020) Laurens F.M. Verscheijden et al.   PHARMACOLOGY & THERAPEUTICS

Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

(2019) Zubida M. Al-Majdoub et al.   MOLECULAR PHARMACEUTICS

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis

(2019) Laurens F. M. Verscheijden et al.   PLoS Computational Biology

Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters

(2019) Kit Wun Kathy Cheung et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver

(2018) Deepak Kumar Bhatt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

(2018) Hajar Al Feteisi et al.   JOURNAL OF NEUROCHEMISTRY

The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance

(2018) Vineet Kumar et al.   DRUG METABOLISM AND DISPOSITION

Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”

(2018) Richard J Weaver et al.   TOXICOLOGICAL SCIENCES

Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissue

(2016) S. Brück et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

The Cerebrospinal Fluid Distribution of Postoperatively Administred Dexketoprofen and Etoricoxib and Their Effect on Pain and Inflammatory Markers in Patients Undergoing Hip Arthroplasty

(2016) Annika Piirainen et al.   CLINICAL DRUG INVESTIGATION

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

(2016) Lu Gaohua et al.   Drug Metabolism and Pharmacokinetics

Measuring citalopram in blood and central nervous system

(2016) Michael Paulzen et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy

(2015) Theodor W. May et al.   EPILEPSIA

Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

(2015) Martin Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Scientific Basis of Uncertainty Factors Used in Setting Occupational Exposure Limits

(2015) D. A. Dankovic et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE

The ontogeny of P-glycoprotein in the developing human blood–brain barrier: implication for opioid toxicity in neonates

(2015) Jessica Lam et al.   PEDIATRIC RESEARCH

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

(2015) Muhammad Waqas Sadiq et al.   PLoS One

Distribution pattern of mirtazapine and normirtazapine in blood and CSF

(2014) Michael Paulzen et al.   PSYCHOPHARMACOLOGY

Central nervous system penetration of oxycodone after intravenous and epidural administration

(2013) M. Kokki et al.   BRITISH JOURNAL OF ANAESTHESIA

Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood–brain barrier permeability

(2013) Fionn E. O'Brien et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

(2013) Sibylle Neuhoff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of permeability‐limited physiologically-based pharmacokinetic models: Part II-prediction of p‐glycoprotein mediated drug–drug interactions with digoxin

(2013) Sibylle Neuhoff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

(R)-[11C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP

(2013) Kerstin Römermann et al.   NUCLEAR MEDICINE AND BIOLOGY

Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches

(2012) Hannah M. Jones et al.   AAPS Journal

In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes

(2012) Ulrich Schmitt et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pgp-Mediated Interaction Between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data

(2011) M Bauer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Substrate- and Species-dependent Inhibition of P-glycoprotein-mediated Transport: Implications for Predicting in vivo Drug Interactions

(2011) Joseph K. Zolnerciks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Relationship between P-glycoprotein and second-generation antipsychotics

(2011) Tim Moons et al.   PHARMACOGENOMICS

Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

(2010) S. Kiki-Mvouaka et al.   DRUG METABOLISM AND DISPOSITION

Quetiapine and Norquetiapine in Plasma and Cerebrospinal Fluid of Schizophrenic Patients Treated With Quetiapine

(2010) Georg Nikisch et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

High Correlation Between Serum and Cerebrospinal Fluid Olanzapine Concentrations in Patients With Schizophrenia or Schizoaffective Disorder Medicating With Oral Olanzapine as the Only Antipsychotic Drug

(2010) Elisabeth Skogh et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors

(2010) F. Wang et al.   NEURO-ONCOLOGY

Organic anion transporting polypeptide 2-mediated uptake of paclitaxel and 2'-ethylcarbonate-linked paclitaxel in freshly isolated rat hepatocytes

(2009) Tadatoshi Tanino et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

(2008) S. Syvanen et al.   DRUG METABOLISM AND DISPOSITION

Brain penetration of ivermectin and selamectin inmdr1a,bP-glycoprotein- andbcrp- deficient knockout mice

(2008) J. GEYER et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS