NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria

Undesirable effects of chemical inhibitors of NAD(P)+ transhydrogenase on mitochondrial respiratory function

(2020) Rafaela Bicego et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure

(2020) Cody D. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses

(2019) Daniel Munro et al.   AGING CELL

Structure and mechanism of mitochondrial proton-translocating transhydrogenase

(2019) Domen Kampjut et al.   NATURE

Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions

(2019) Victoria A. Guarino et al.   Scientific Reports

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

(2018) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

H 2 O 2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems

(2018) Collins Kamunde et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet

(2018) Annelise Francisco et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondria can act as energy-sensing regulators of hydrogen peroxide availability

(2018) Jason R. Treberg et al.   Redox Biology

Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice

(2017) Claudia D.C. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice

(2016) Kelsey H. Fisher-Wellman et al.   DIABETES

Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies

(2016) Dawid Dębski et al.   FREE RADICAL BIOLOGY AND MEDICINE

The thioredoxin and glutathione-dependent H2O2 consumption pathways in muscle mitochondria: Involvement in H2O2 metabolism and consequence to H2O2 efflux assays

(2016) Daniel Munro et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria

(2016) Juliana Aparecida Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Decarboxylation of Pyruvic Acid in the Presence of Hydrogen Peroxide

(2016) Antonio Lopalco et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit

(2015) Kelsey H. Fisher-Wellman et al.   BIOCHEMICAL JOURNAL

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

(2015) Alexander G. Nickel et al.   Cell Metabolism

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium

(2015) Danielle A. Fontaine et al.   DIABETES

Tissue and sex specificities in Ca2+handling by isolated mitochondria in conditions avoiding the permeability transition

(2015) Hanan Chweih et al.   EXPERIMENTAL PHYSIOLOGY

Increased Susceptibility ofGracilinanus microtarsusLiver Mitochondria to Ca2+-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P)

(2015) Juliana A. Ronchi et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle

(2015) S. Schiaffino et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Differentiating between apparent and actual rates of H 2 O 2 metabolism by isolated rat muscle mitochondria to test a simple model of mitochondria as regulators of H 2 O 2 concentration

(2015) Jason R. Treberg et al.   Redox Biology

Parallel universes of Black Six biology

(2014) Alexander Kraev   Biology Direct

Scavenging of H2O2 by mouse brain mitochondria

(2014) Anatoly A. Starkov et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of Glutamate Dehydrogenase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)

(2014) Dennis Botman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A word of caution concerning the use ofNnt-mutated C57BL/6 mice substrains as experimental models to study metabolism and mitochondrial pathophysiology

(2013) Tiago R. Figueira   EXPERIMENTAL PHYSIOLOGY

The pH sensitivity of H2O2metabolism in skeletal muscle mitochondria

(2013) Sheena Banh et al.   FEBS LETTERS

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities

(2013) Juliana A. Ronchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency

(2012) Eirini Meimaridou et al.   NATURE GENETICS

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase

(2010) Ryan J. Mailloux et al.   FASEB JOURNAL

Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production - a correction using glutathione depletion

(2010) Jason R. Treberg et al.   FEBS Journal

Genetic polymorphisms among C57BL/6 mouse inbred strains

(2010) Esther Zurita et al.   TRANSGENIC RESEARCH

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria

(2009) Nadeene Parker et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION