Article
Rheumatology
Vinod Chandran, Vladislav A. Malkov, Kaori L. Ito, Yihua Liu, Lene Vestergaard, Oh Kyu Yoon, Jinfeng Liu, Mona Trivedi, Angie Hertz, Dafna Gladman
Summary: This study aimed to identify protein and transcriptional biomarkers and pathways associated with PsA disease state, the effect of FIL treatment, and the mechanism of action of FIL on clinical improvement. The results showed that FIL treatment downregulates inflammation and immune pathways, leading to clinical improvement in PsA.
Article
Immunology
Nuria Barbarroja, Maria Dolores Lopez-Montilla, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Miriam Ruiz-Ponce, Clementina Lopez-Medina, Maria Lourdes Ladehesa-Pineda, Chary Lopez-Pedrera, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Ivan Arias-de la Rosa
Summary: This study characterized the inflammatory proteome of synovial fluid in patients with Psoriatic Arthritis (PsA) using a high-throughput proteomic platform. The results showed the presence of 79 inflammation-related proteins in the synovial fluid of PsA patients, and identified two specific phenotypes based on the levels of these proteins. Additionally, compared to patients with osteoarthritis, PsA patients had significantly altered levels of 39 proteins specifically related to cell migration and inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Anna Scanu, Mariagrazia Lorenzin, Roberto Luisetto, Paola Galozzi, Augusta Ortolan, Francesca Oliviero, Andrea Doria, Roberta Ramonda
Summary: This study evaluates the levels and expression of STING protein in synovial fluid of patients with different types of arthritis, and suggests that STING may be involved in the pathogenesis and progression of arthropathies, except for psoriatic arthritis where STING was not detectable.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Letter
Immunology
Francesco Caso, Anella Saviano, Marco Tasso, Federica Raucci, Noemi Marigliano, Saverio Passavanti, Paola Frallonardo, Roberta Ramonda, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele Scarpa, Luisa Costa, Francesco Maione
Summary: This study compared the expression levels of cyto-chemokines in PsA and RA synovial fluid, finding unique and specific modulation of CCL-2, G-CSF, IL-1 beta, and TNF-alpha in RA synovial fluid, and significantly higher levels of ICAM-1, IL-2, IL-6, IL-17A, C5a, and CXCL-9/12 in PsA patients. The expression of CCR2 was significantly upregulated in both PsA and RA groups, along with specific Th and Treg transcription factors such as STAT3/4 and FOXP3.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, General & Internal
Mariela Geneva-Popova, Stanislava Popova-Belova, Velicka Popova, Nikolay Stoilov
Summary: This study found that the presence of crystals in the synovial fluid of PsA patients is associated with disease activity, disability, and pain. The findings suggest that examining synovial fluid can be helpful in determining treatment options for PsA patients.
Article
Immunology
Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra
Summary: In patients with rheumatoid arthritis, regulatory T cells in the synovial fluid are impaired in their function. Blocking the action of IL-9 can restore the function of regulatory T cells and reduce the production of inflammatory T cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Shaowei Li, Shudan Zhang, Zhihuang Chen, Xianxian Zhang, Rui Ou, Song Wei, Yingwan Liu, Yiwen Xu, Kaixin Chen, Zhouyi Chen, Xinnong Shu
Summary: This study compared the ultracentrifugation method and polyethylene glycol precipitation method for the isolation of exosomes in gouty arthritis synovial fluid (GASF), and observed the potential influence of different isolation methods on cytokine analysis. The results showed that the ultracentrifugation method yielded exosomes with higher purity but lower quantity and more abundant inflammatory cytokines, whereas the opposite was the case for the polyethylene glycol precipitation method. Based on these findings, the chemical precipitation method may not be suitable for extracting GASF-derived exosomes for inflammation and immunity studies.
Article
Medicine, General & Internal
Andrea Cuervo, Raquel Celis, Antonio Julia, Alicia Usategui, Regina Fare, Julio Ramirez, Ana Belen Azuaga, Andres Lorenzo, Raimon Sanmarti, Jose L. Pablos, Juan D. Canete
Summary: The study found that the cellular composition of synovium in undifferentiated arthritis (UA) patients differs from rheumatoid arthritis (RA) and psoriatic arthritis (PsA), with higher cellular infiltrate density in the UA group. Initial expression of the interferon inducible gene MxA may serve as a biomarker for progression to RA, while higher mast cell and fibroblastic density may be associated with PsA progression.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Layth Ben-Trad, Constantin Ionut Matei, Mirela Maria Sava, Samira Filali, Marie-Eve Duclos, Yves Berthier, Michel Guichardant, Nathalie Bernoud-Hubac, Ofelia Maniti, Ahmed Landoulsi, Marie-Genevieve Blanchin, Pierre Miossec, Thierry Granjon, Ana-Maria Trunfio-Sfarghiu
Summary: This study compares the biochemical, tribological, and ultrastructural properties of synovial fluid in healthy individuals and patients with osteoarthritis and arthritis, finding differences that indicate the importance of synovial fluid in joint mechanics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wail M. Hassan, Nashwa Othman, Maha Daghestani, Arjumand Warsy, Maha A. Omair, Eman Alqurtas, Shireen Amin, Abdulaziz Ismail, Afaf El-Ansary, Ramesa Shafi Bhat, Mohammed A. Omair
Summary: This study aimed to explore the role of cytokines in the early diagnosis of rheumatoid arthritis (RA). By analyzing the levels of cytokines in the serum, we found that multiple cytokine profiles were able to successfully distinguish RA patients from healthy controls. Additionally, the use of gender-specific models may have some benefits in clinical diagnosis.
Article
Biochemistry & Molecular Biology
Sara Cheleschi, Sara Tenti, Sauro Lorenzini, Iole Seccafico, Stefano Barbagli, Elena Frati, Antonella Fioravanti
Summary: This study reveals the influence of synovial fluid from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) on microRNA expression in human OA chondrocytes. The findings suggest that synovial fluid regulates miRNA involved in inflammation and cartilage degradation through the NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nina Vindegaard Sorensen, Nis Borbye-Lorenzen, Rune Haubo Bojesen Christensen, Sonja Orlovska-Waast, Rose Jeppesen, Kristin Skogstrand, Michael Eriksen Benros
Summary: By analyzing the cytokine levels in the cerebrospinal fluid (CSF) of patients with recent-onset depression and healthy controls, this study found that IL-4, MCP-1, and MIP-1 beta levels were significantly higher in patients with depression compared to healthy controls, while IL-6 and IL-8 levels showed no significant differences.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
N. Sippl, F. Faustini, J. Ronnelid, S. Turcinov, K. Chemin, I. Gunnarsson, V. Malmstrom
Summary: This study found elevated levels of IL-17A and IL-6 in the synovial fluids of patients with lupus arthritis, with a subset of CD4(+) T cells expressing markers associated with Th17 cells. Strong production of IFN-gamma was observed in both CD4(+) and CD8(+) cells, suggesting Th17 involvement in lupus arthritis.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Virology
Jialu Xu, Zeyu Sun, Wei Li, Lifang Liu, Feng Gao, Dongli Pan
Summary: This study investigated the epidemiology and pathology of Enterovirus (EV) encephalitis in children in Hangzhou, China, revealing higher positivity rates in boys, peaks in cases from June to August, and elevated levels of 28 cytokines and chemokines in EV-positive samples. Age, sex, and seasonal preferences were identified, providing insights into the characteristics of EV encephalitis in children.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Paola Galozzi, Francesca Oliviero, Anna Scanu, Mariagrazia Lorenzin, Augusta Ortolan, Marta Favero, Andrea Doria, Roberta Ramonda
Summary: The study aims to describe acute joint swelling in patients with psoriatic arthritis (PsA) through synovial fluid analysis, with a focus on the presence of pathogenic crystals, and determine whether it is a flare or an acute episode of gout (psout). Results indicate that although the risk of gout is higher among PsA patients, the presence of urate crystals is rare and hyperuricemia does not seem to modify synovial fluid features in PsA patients.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Respiratory System
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Joe Butler, Lonneke A. van Vught, Katie L. Burnham, Emma E. Davenport, Julian C. Knight, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll
Summary: The host immune response does not differ between patients with community-acquired pneumonia (CAP) caused by gram-positive or gram-negative bacteria upon admission to the intensive care unit (ICU).
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Medicine, General & Internal
P. Maclean, A. J. Mentzer, T. Lambe, J. C. Knight
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Genetics & Heredity
Carla J. Cohen, Connor Davidson, Carlo Selmi, Paul Bowness, Julian C. Knight, B. Paul Wordsworth, Matteo Vecellio
Summary: Ankylosing Spondylitis (AS) is a complex and highly heritable form of inflammatory spinal arthritis. This study investigated the effect of the rs6600247 genotype on DNA binding and chromosome looping in relation to RUNX3, a gene associated with AS.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Vicente Peris Sempere, Sergio Muniz-Castrillo, Aditya Ambati, Sophie Binks, Anne-Laurie Pinto, Veronique Rogemond, Sean J. Pittock, Divyanshu Dubey, Michael D. Geschwind, Jeffrey Marc Gelfand, Sonam Dilwali, Soon-Tae Lee, Julian Knight, Katherine S. Elliott, Sarosh Irani, Jerome Honnorat, Emmanuel Mignot
Summary: The study found that HLA alleles DRB1*07:01 and DQA1*02:01 are associated with anti-LGI1 encephalitis, independent of variation at DRB3 and DQB1 loci. Additionally, the DRB1*04:02 allele is also independently associated with the disease and lower age at onset. These findings provide evidence for secondary effects within the HLA locus that correlate with clinical phenotypes in anti-LGI1 encephalitis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
David J. Ahern, Zhichao Ai, Mark Ainsworth, Chris Allan, Alice Allcock, Brian Angus, M. Azim Ansari, Carolina Arancibia-Carcamo, Dominik Aschenbrenner, Moustafa Attar, J. Kenneth Baillie, Eleanor Barnes, Rachael Bashford-Rogers, Archana Bashyal, Sally Beer, Georgina Berridge, Amy Beveridge, Sagida Bibi, Tihana Bicanic, Luke Blackwell, Paul Bowness, Andrew Brent, Andrew Brown, John Broxholme, David Buck, Katie L. Burnham, Helen Byrne, Susana Camara, Ivan Candido Ferreira, Philip Charles, Wentao Chen, Yi-Ling Chen, Amanda Chong, Elizabeth A. Clutterbuck, Mark Coles, Christopher P. Conlon, Richard Cornall, Adam P. Cribbs, Fabiola Curion, Emma E. Davenport, Neil Davidson, Simon Davis, Calliope A. Dendrou, Julie Dequaire, Lea Dib, James Docker, Christina Dold, Tao Dong, Damien Downes, Hal Drakesmith, Susanna J. Dunachie, David A. Duncan, Chris Eijsbouts, Robert Esnouf, Alexis Espinosa, Rachel Etherington, Benjamin Fairfax, Rory Fairhead, Hai Fang, Shayan Fassih, Sally Felle, Maria Fernandez Mendoza, Ricardo Ferreira, Roman Fischer, Thomas Foord, Aden Forrow, John Frater, Anastasia Fries, Veronica Gallardo Sanchez, Lucy C. Garner, Clementine Geeves, Dominique Georgiou, Leila Godfrey, Tanya Golubchik, Maria Gomez Vazquez, Angie Green, Hong Harper, Heather A. Harrington, Raphael Heilig, Svenja Hester, Jennifer Hill, Charles Hinds, Clare Hird, Ling-Pei Ho, Renee Hoekzema, Benjamin Hollis, Jim Hughes, Paula Hutton, Matthew A. Jackson-Wood, Ashwin Jainarayanan, Anna James-Bott, Kathrin Jansen, Katie Jeffery, Elizabeth Jones, Luke Jostins, Georgina Kerr, David Kim, Paul Klenerman, Julian C. Knight, Vinod Kumar, Piyush Kumar Sharma, Prathiba Kurupati, Andrew Kwok, Angela Lee, Aline Linder, Teresa Lockett, Lorne Lonie, Maria Lopopolo, Martyna Lukoseviciute, Jian Luo, Spyridoula Marinou, Brian Marsden, Jose Martinez, Philippa C. Matthews, Michalina Mazurczyk, Simon McGowan, Stuart McKechnie, Adam Mead, Alexander J. Mentzer, Yuxin Mi, Claudia Monaco, Ruddy Montadon, Giorgio Napolitani, Isar Nassiri, Alex Novak, Darragh P. O'Brien, Daniel O'Connor, Denise O'Donnell, Graham Ogg, Lauren Overend, Inhye Park, Ian Pavord, Yanchun Peng, Frank Penkava, Mariana Pereira Pinho, Elena Perez, Andrew J. Pollard, Fiona Powrie, Bethan Psaila, T. Phuong Quan, Emmanouela Repapi, Santiago Revale, Laura Silva-Reyes, Jean-Baptiste Richard, Charlotte Rich-Griffin, Thomas Ritter, Christine S. Rollier, Matthew Rowland, Fabian Ruehle, Mariolina Salio, Stephen Nicholas Sansom, Raphael Sanches Peres, Alberto Santos Delgado, Tatjana Sauka-Spengler, Ron Schwessinger, Giuseppe Scozzafava, Gavin Screaton, Anna Seigal, Malcolm G. Semple, Martin Sergeant, Christina Simoglou Karali, David Sims, Donal Skelly, Hubert Slawinski, Alberto Sobrinodiaz, Nikolaos Sousos, Lizzie Stafford, Lisa Stockdale, Marie Strickland, Otto Sumray, Bo Sun, Chelsea Taylor, Stephen Taylor, Adan Taylor, Supat Thongjuea, Hannah Thraves, John A. Todd, Adriana Tomic, Orion Tong, Amy Trebes, Dominik Trzupek, Felicia Anna Tucci, Lance Turtle, Irina Udalova, Holm Uhlig, Erinke van Grinsven, Iolanda Vendrell, Marije Verheul, Alexandru Voda, Guanlin Wang, Lihui Wang, Dapeng Wang, Peter Watkinson, Robert Watson, Michael Weinberger, Justin Whalley, Lorna Witty, Katherine Wray, Luzheng Xue, Hing Yuen Yeung, Zixi Yin, Rebecca K. Young, Jonathan Youngs, Ping Zhang, Yasemin-Xiomara Zurke
Summary: The study presents a comprehensive blood atlas for patients with varying severity of COVID-19, compared to influenza, sepsis patients, and healthy volunteers. The results identify immune signatures and correlates of host response, including cells, inflammatory mediators, immune repertoire, and metabolic and coagulation features. The study also reveals that persistent immune activation is a specific feature of COVID-19. Plasma proteomic analysis enables sub-phenotyping and prediction of severity and outcome. Integrative analyses show feature groupings linked with severity and specificity compared to influenza and sepsis.
Article
Biochemistry & Molecular Biology
Katherine S. Elliott, Marc Haber, Hinda Daggag, George B. Busby, Rizwan Sarwar, Derek Kennet, Michael Petraglia, Lawrence J. Petherbridge, Parisa Yavari, Frauke U. Heard-Bey, Bindu Shobi, Tariq Ghulam, Dalia Haj, Alia Al Tikriti, Alshafi Mohammad, Suma Antony, Maitha Alyileili, Shatha Alaydaroos, Evelyn Lau, Mark Butler, Arash Yavari, Julian C. Knight, Houman Ashrafian, Maha T. Barakat
Summary: The indigenous population of the UAE has a unique demographic and cultural history, characterized by endogamy and consanguinity. This has led to genetic homogeneity and partitioning of gene pools. However, population movements and intercontinental trade have contributed to genetic diversity. This study explores the genetic structure of the Emirati population using genotype data from 1,198 individuals and reveals shared ancestry, gene flow with neighboring populations, and the influence of endogamous and consanguineous cultural traditions.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Alexander J. Mentzer, Nicole Brenner, Naomi Allen, Thomas J. Littlejohns, Amanda Y. Chong, Adrian Cortes, Rachael Almond, Michael Hill, Simon Sheard, Gil McVean, Rory Collins, Adrian V. S. Hill, Tim Waterboer
Summary: The authors designed a multiplex serology platform to measure quantitative antibody responses against 20 infectious agents and confirmed their associations with sociodemographic characteristics, HLA genetic variants, and disease outcomes. The findings provide valuable insights into host-pathogen-disease relationships.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Li Guo, Geng Wang, Yeming Wang, Qiao Zhang, Lili Ren, Xiaoying Gu, Tingxuan Huang, Jingchuan Zhong, Ying Wang, Xinming Wang, Lixue Huang, Liuhui Xu, Conghui Wang, Lan Chen, Xia Xiao, Yanchun Peng, Julian C. Knight, Tao Dong, Bin Cao, Jianwei Wang
Summary: This study investigated the durability and functionality of the humoral and T-cell response to the original SARS-CoV-2 strain and variants in recovered patients 12 months after infection. The results showed that neutralising antibodies and T-cell responses were retained 12 months after initial infection. However, the neutralising antibody responses to the D614G, beta, and delta variants were reduced compared to the original strain, while T-cell responses were cross-reactive to the beta variant. This suggests that cross-reactive T-cell responses may be particularly important in protecting against severe disease caused by variants, while neutralising antibody responses seem to diminish over time.
Article
Hematology
Claire S. Whyte, Megan Simpson, Gael B. Morrow, Carol A. Wallace, Alexander J. Mentzer, Julian C. Knight, Susan Shapiro, Nicola Curry, Catherine N. Bagot, Henry Watson, Jamie G. Cooper, Nicola J. Mutch
Summary: This study investigates the dysregulation of the fibrinolytic system in COVID-19 disease and finds that elevated levels of PAI-1 suppress plasmin generation, leading to suboptimal fibrinolysis. These findings have important implications for the treatment and prognostic potential of COVID-19 disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
David M. Maslove, Benjamin Tang, Manu Shankar-Hari, Patrick R. Lawler, Derek C. Angus, J. Kenneth Baillie, Rebecca M. Baron, Michael Bauer, Timothy G. Buchman, Carolyn S. Calfee, Claudia C. dos Santos, Evangelos J. Giamarellos-Bourboulis, Anthony C. Gordon, John A. Kellum, Julian C. Knight, Aleksandra Leligdowicz, Daniel F. McAuley, Anthony S. McLean, David K. Menon, Nuala J. Meyer, Lyle L. Moldawer, Kiran Reddy, John P. Reilly, James A. Russell, Jonathan E. Sevransky, Christopher W. Seymour, Nathan I. Shapiro, Mervyn Singer, Charlotte Summers, Timothy E. Sweeney, B. Taylor Thompson, Tom van der Poll, Balasubramanian Venkatesh, Keith R. Walley, Timothy S. Walsh, Lorraine B. Ware, Hector R. Wong, Zsolt E. Zador, John C. Marshall
Summary: The authors propose a new conceptual model of critical illness that moves away from the current syndrome-based framework and focuses on more precise biological descriptors. They discuss the need to reconsider the current approach based on syndromes and instead emphasize the underlying biological changes that underpin critical illness states. By doing so, they believe it will lead to a better understanding of the pathobiology of critical illness and improved patient outcomes.
Article
Multidisciplinary Sciences
James J. Gilchrist, Seiko Makino, Vivek Naranbhai, Piyush K. Sharma, Surya Koturan, Orion Tong, Chelsea A. Taylor, Robert A. Watson, Alba Verge de los Aires, Rosalin Cooper, Evelyn Lau, Sara Danielli, Dan Hameiri-Bowen, Wanseon Lee, Esther Ng, Justin Whalley, Julian C. Knight, Benjamin P. Fairfax
Summary: The study maps regulatory genetic variation in Natural Killer cells, providing new insights into their role in human health and disease. The findings reveal unique expression quantitative trait loci of Natural Killer cells compared to other immune cells, with implications for disease mechanisms.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dapeng Wang, Vinod Kumar, Katie L. Burnham, Alexander J. Mentzer, Brian D. Marsden, Julian C. Knight
Summary: The COvid-19 Multi-omics Blood ATlas (COMBAT) project has developed a database, COMBATdb, for exploring multi-modal datasets related to COVID-19 and other infectious diseases.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Janine H. Collins, Kate Downes, Luigi Grassi, Jose A. Guerrero, Stephen Kaptoge, Julian C. Knight, Stuart Meacham, Jennifer Sambrook, Denis Seyres, Oliver Stegle, Jeffrey M. Verboon, Klaudia Walter, Nicholas A. Watkins, John Danesh, David J. Roberts, Emanuele Di Angelantonio, Vijay G. Sankaran, Mattia Frontini, Stephen Burgess, Taco Kuijpers, James E. Peters, Adam S. Butterworth, Willem H. Ouwehand, Nicole Soranzo, William J. Astle
Summary: The authors identify genetic variation associated with properties of the internal biological structures of blood cells and demonstrate how this can contribute to our understanding of the cellular mechanisms causing disease.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Ping Zhang, Harindra E. Amarasinghe, Justin P. Whalley, Chwen Tay, Hai Fang, Gabriele Migliorini, Andrew C. Brown, Alice Allcock, Giuseppe Scozzafava, Phalguni Rath, Benjamin Davies, Julian C. Knight
Summary: This study systematically investigates the acute innate immune response to endotoxin in human macrophages and compares it with endotoxin tolerance. It provides insights into the regulatory networks involved in enhancer activities and biological processes, and reveals the importance of context-specific macrophage enhancers in gene regulation and interpreting disease associations. The study also identifies specific differential enhancer regions and links genetic variants with molecular and cellular functions.
Article
Microbiology
Ashley David Otter, Abbie Bown, Silvia D'Arcangelo, Daniel Bailey, Amanda Semper, Jacqueline Hewson, Matthew Catton, Prem Perumal, Angela Sweed, Deborah Fox McKee, Jessica Jones, Heli Harvala, Abigail Lamikanra, Maria Zambon, Nick Andrews, Heather Whitaker, Ezra Linley, Alexander J. Mentzer, Donal Skelly, Julian C. Knight, Paul Klenerman, Gayatri Amirthalingam, Stephen Taylor, Cathy Rowe, Richard Vipond, Tim Brooks
Summary: This article introduces the establishment of a national surveillance laboratory facility by the UK Health Security Agency during the COVID-19 pandemic, and provides a detailed evaluation of the performance and characteristics of the Euroimmun anti-SARS-CoV-2 IgG assay.
MICROBIOLOGY SPECTRUM
(2022)