The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions

IRS proteins and diabetic complications

(2016) Deborah P. Lavin et al.   DIABETOLOGIA

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

(2016) Preeta Dasgupta et al.   Science Signaling

The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation

(2016) Preeta Dasgupta et al.   Science Signaling

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

(2015) Haiyang Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary HypertensionSignificance

(2015) Roger A. Johns et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

(2015) Kurt R. Stenmark et al.   JOURNAL OF APPLIED PHYSIOLOGY

Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension

(2014) Kazuyo Yamaji-Kegan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity

(2014) M. F. White   DIABETES OBESITY & METABOLISM

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling

(2013) Daniel J Angelini et al.   RESPIRATORY RESEARCH

Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

(2013) W. Tian et al.   Science Translational Medicine

Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients

(2012) Chris Cheadle et al.   PLoS One

Regulatory T Cells and Pulmonary Hypertension

(2012) Rasa Tamosiuniene et al.   TRENDS IN CARDIOVASCULAR MEDICINE

New Models of Pulmonary Hypertension Based on VEGF Receptor Blockade-Induced Endothelial Cell Apoptosis

(2012) Mark R. Nicolls et al.   Pulmonary Circulation

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The insulin receptor substrate (IRS) proteins

(2011) Leslie M. Shaw   CELL CYCLE

Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension

(2011) Eleni Vergadi et al.   CIRCULATION

Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

(2011) Rasa Tamosiuniene et al.   CIRCULATION RESEARCH

Schistosomiasis-Induced Experimental Pulmonary Hypertension

(2010) Brian B. Graham et al.   AMERICAN JOURNAL OF PATHOLOGY

Schistosomiasis-Associated Pulmonary Hypertension

(2010) Brian B. Graham et al.   CHEST

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Hypoxia-Induced Mitogenic Factor (HIMF/FIZZ1/RELM ) Increases Lung Inflammation and Activates Pulmonary Microvascular Endothelial Cells via an IL-4-Dependent Mechanism

(2010) K. Yamaji-Kegan et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Induced Mitogenic Factor (HIMF/FIZZ1/RELMα) Recruits Bone Marrow-Derived Cells to the Murine Pulmonary Vasculature

(2010) Daniel J. Angelini et al.   PLoS One

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) induces the vascular and hemodynamic changes of pulmonary hypertension

(2009) Daniel J. Angelini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resistin-Like Molecule-β in Scleroderma-Associated Pulmonary Hypertension

(2009) Daniel J. Angelini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions

(2009) K. Yamaji-Kegan et al.   JOURNAL OF IMMUNOLOGY

Insulin resistance in pulmonary arterial hypertension

(2008) R. T. Zamanian et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary arterial remodeling induced by a Th2 immune response

(2008) Eleen Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling