Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol‐impaired TFEB and liver injury in mice

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response

(2021) Se-Jin Jeong et al.   Autophagy

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

INTEGRATED MULTI-OMICS REVEALS GLUCOSE USE REPROGRAMMING AND IDENTIFIES A NOVEL HEXOKINASE IN ALCOHOLIC HEPATITIS

(2020) Veronica Massey et al.   GASTROENTEROLOGY

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

(2019) Yusha Wang et al.   EMBO REPORTS

Insufficient Autophagy: A Novel Autophagic Flux Scenario Uncovered by Impaired Liver TFEB-Mediated Lysosomal Biogenesis From Chronic Alcohol-Drinking Mice

(2018) Xiaojuan Chao et al.   Autophagy

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

The cryoprotectant trehalose could inhibit ERS-induced apoptosis by activating autophagy in cryoprotected rat valves

(2018) Hongyan Wu et al.   PLoS One

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

A Gene Transcription Program Decides the Differential Regulation of Autophagy by Acute Versus Chronic Ethanol?

(2016) Yuan Li et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

Alcoholic Liver Disease in Asia, Europe, and North America

(2016) Suthat Liangpunsakul et al.   GASTROENTEROLOGY

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes

(2016) Laura E. Nagy et al.   GASTROENTEROLOGY

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1

(2016) Qiurong Wang et al.   PHARMACOLOGICAL RESEARCH

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

(2016) Shaogui Wang et al.   Oncotarget

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

(2016) Brian J. DeBosch et al.   Science Signaling

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

(2015) Paul G. Thomes et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

(2015) Wei Zhong et al.   JOURNAL OF HEPATOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases

(2014) Jessica A Williams et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

A RANKL-PKC -TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

(2013) M. Ferron et al.   GENES & DEVELOPMENT

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Autophagy in Alcohol-Induced Liver Diseases

(2012) Angela Dolganiuc et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Alcohol Metabolism

(2012) Arthur I. Cederbaum   Clinics in Liver Disease

The emerging role of autophagy in alcoholic liver disease

(2011) Wen-Xing Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

(2011) M.J. Casarejos et al.   NEUROCHEMISTRY INTERNATIONAL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effect of trehalose on protein structure

(2009) Nishant Kumar Jain et al.   PROTEIN SCIENCE

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY