Article
Immunology
Wirawan Adikusuma, Lalu Muhammad Irham, Wan-Hsuan Chou, Henry Sung-Ching Wong, Eko Mugiyanto, Jafit Ting, Dyah Aryani Perwitasari, Wei-Pin Chang, Wei-Chiao Chang
Summary: This study aimed to discover potential treatments for Atopic Dermatitis (AD) by integrating gene networking and genomic information. The research identified 27 biological AD risk genes mapped to 76 drug target genes, with 25 drug target genes overlapping with 53 drugs. The study also found several potential drugs for AD, including filgotinub and fedratinib targeting gene JAK1, as well as four monoclonal antibody drugs deemed promising for AD repurposing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ting Zheng, Miao Fan, Yunbo Wei, Jinhong Feng, Pengcheng Zhou, Xin Sun, Anqi Xue, Cheng Xue Qin, Di Yu
Summary: Atopic dermatitis, characterized by allergic skin inflammation, redness, and itchiness, lacks effective pharmacotherapies due to its complex causes. Traditional Chinese medicine Huangbai Liniment (HB) has shown significant therapeutic potential in both experimental models and AD patients, alleviating skin inflammation by regulating immune balance.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Cristina Barbagallo, Antonio Di Maria, Adriana Alecci, Davide Barbagallo, Salvatore Alaimo, Lorenzo Colarossi, Alfredo Ferro, Cinzia Di Pietro, Michele Purrello, Alfredo Pulvirenti, Marco Ragusa
Summary: The study introduces the VECTOR database, which can identify and visualize relationships among RNA molecules based on the ceRNA model. The database contains expression correlation values of miRNA-mRNA, miRNA-lncRNA, and lncRNA-mRNA pairs combined with predicted or validated RNA-RNA interactions, as well as other related data.
Review
Immunology
Anni Xie, Ailing Chen, Yuqing Chen, Zichen Luo, Shanyu Jiang, Daozhen Chen, Renqiang Yu
Summary: Atopic dermatitis is a chronic inflammatory skin disease with itching and swelling. Probiotics, especially certain strains of Lactobacillus, can provide a safe and effective way to treat and prevent AD by regulating the immune system and improving gut health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fangli Peng, Junwei Zong, Tianqi Zhao, Peng Shi, Ming Lu, Xueling Qu, Xin Han, Lin Zhao, Zhuqiang Jia, Shouyu Wang
Summary: The polysaccharide extracted from the traditional Chinese medicine Wuguchong (PEW) has been found to have anti-inflammatory and immunomodulatory effects on atopic dermatitis (AD). It can inhibit Th1 and Th17 responses, downregulate the NF-κB and MAPK pathways, and potentially serve as a promising immune therapy for AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Jun Mao, Mingzhi Lu, Siduo Lu, Yiqiao Xing, Xuejiao Xu, Ying Chen, Huirong Xu, Wei Zuo, Jingwen Zhou, Wei Du
Summary: This study aimed to identify biomarkers for retinoblastoma (RB) and explore the molecular mechanisms associated with such markers. Through gene analysis, several DERBGs, including PDE8B, ESRRB, and SPRY2, were identified as potential key genes for RB diagnosis and treatment.
BMC MEDICAL GENOMICS
(2023)
Article
Cell Biology
Ming-Yu Ran, Zhang Yuan, Chui-Ting Fan, Zhou Ke, Xin-Xing Wang, Jia-Yuan Sun, Dong-Ju Su
Summary: Asthma is a complex respiratory disorder involving genetic variants and transcriptome. Integrating scattered information and exploring new insights can enhance understanding of asthma communication. This study identified potential mechanisms of asthma pathogenesis by analyzing characteristics like airway inflammation and hyperresponsiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Yinggang Xiao, Yang Zhang, Cunjin Wang, Yali Ge, Ju Gao, Tianfeng Huang
Summary: Using bioinformatics methods, we identified key autophagy genes in ICH and explored their mechanisms. IL-1B, STAT3, NLRP3, and NOD2 were identified as key genes with clinical predictive value. These key genes were positively correlated with immune cell infiltration level and mainly involved in cytokine and receptor interactions and immune responses.
FRONTIERS IN GENETICS
(2023)
Article
Biochemical Research Methods
Tong Wang, Mao-yuan Cheng, Meng-ya Shan, Cui-yao Tang, Nai-jia Pan, Zi-hui Xu, Xian-lun Tang
Summary: In this study, a ceRNA network related to exosomes in diabetic retinopathy (DR) was constructed based on the competing endogenous RNA (ceRNA) network. Through analysis, differentially expressed lncRNAs (DELs), miRNAs (DEMs) and mRNAs (DEGs) were identified. The ceRNA network consisted of 15 lncRNAs, 3 miRNAs and 11 mRNAs, which were closely associated with the occurrence and development of DR.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Multidisciplinary Sciences
Yingying Hong, Jiawen Wu, Yang Sun, Shenghai Zhang, Yi Lu, Yinghong Ji
Summary: This study aimed to investigate the genetic and epigenetic mechanisms involved in age-related cataract (ARC) pathogenesis. The findings revealed that the FOXO1 gene was the most important hub gene in the ARC network, and several lncRNAs and target genes played crucial roles in regulating ARC progression. Furthermore, these key genes were closely associated with cell metabolism but showed no significant correlation with immune response.
Article
Immunology
Qiuyan Xie, Hongwen Yu, Zining Liu, Bangyi Zhou, Fuchun Fang, Wei Qiu, Hongle Wu
Summary: In this study, two ceRNA networks were constructed and 6 hub lncRNAs were identified, providing novel insights into the relationship between ferroptosis and irreversible pulpitis (IP). The LINC00943/hsa-miR-29a-3p/PDK4 axis was deemed to be the key node in this network.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jie Huang, Jianxiong Ma, Jie Wang, Ke Ma, Kang Zhou, Wenjie Huang, Fan Zhao, Bodong Lv, Qing Hu
Summary: The study revealed a potential link between circRNAs, miRNAs, and mRNAs in cavernous nerve-damaging erectile dysfunction (CNI-ED), suggesting that circRNAs may contribute to the occurrence of ED by regulating cellular energy metabolism in CNI-ED.
Article
Biotechnology & Applied Microbiology
Xiangzhou Tan, Linfeng Mao, Changhao Huang, Weimin Yang, Jianping Guo, Zhikang Chen, Zihua Chen
Summary: Recent research has identified microbiota as crucial players in various disease conditions, including cancers, with ceRNA mechanisms playing a role in these biological processes. By constructing ceRNA networks using TCGA and GEO databases, potential mechanisms of microbiota-mediated colorectal carcinogenesis and progression were explored. The study revealed two distinct ceRNA networks associated with metabolic processes and unique pathways, as well as suggesting prognostic factors, lncRNAs linked to survival outcomes, and potential anticancer drugs. Additionally, a gene signature significantly correlated with immune infiltration levels was identified, providing insight into how microbiota regulate ceRNA networks and impact colorectal cancer development.
Article
Engineering, Biomedical
Yu-Hsiu Chiu, Yan-Wei Wu, Jui- Hung, Mei-Chin Chen
Summary: The study shows that poly-gamma-glutamate microneedles can efficiently deliver epigallocatechin gallate into the skin to ameliorate symptoms of atopic dermatitis. This formulation not only protects EGCG from oxidation, but also modulates immune response to relieve allergic reactions, presenting a promising therapeutic option for AD treatment.
ACTA BIOMATERIALIA
(2021)
Article
Medicine, Research & Experimental
Haozhen Yu, Mujun Yu, Zhuang Li, Enhu Zhang, Heng Ma
Summary: This study identified mitochondria-related genes (Mito-RGs) in heart failure (HF) using transcriptome sequencing data. The key genes IFIT3, XAF1, RSAD2, and MX1 were found to be enriched in myogenesis and hypoxia, and immune cell analysis showed differences between HF and normal groups. It was also discovered that H19 and PCGEM1 may affect the expression of these key genes. Additionally, potential therapeutic drugs targeting the key genes were predicted and validated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Shixiong Peng, Teng Zhang, Sisi Zhang, Qian Tang, Yang Yan, Hao Feng
Summary: This study investigated the molecular mechanism of pyroptosis-related genes in chronic spontaneous urticaria (CSU) and identified IL1B and its related molecules as potential key biomarkers in the development of CSU.
FRONTIERS IN IMMUNOLOGY
(2022)