Loss of p16: A Bouncer of the Immunological Surveillance?

Suppression of p16 alleviates the senescence-associated secretory phenotype

(2021) Raquel Buj et al.   Aging-US

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

(2020) Hui Che et al.   eLife

Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

(2020) Thomas T. DeLeon et al.   PLoS One

Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

(2020) Ellen Brenner et al.   Nature Communications

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

(2020) Raju K. Vaddepally et al.   Cancers

Non‐canonical ATM / MRN activities temporally define the senescence secretory program

(2020) Nicolas Malaquin et al.   EMBO REPORTS

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

(2020) Hyungsoo Kim et al.   Science Translational Medicine

Distinct Mutation Patterns Reveal Melanoma Subtypes and Influence Immunotherapy Response in Advanced Melanoma Patients

(2020) Franz J. Hilke et al.   Cancers

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

(2019) Emanuel J. Novais et al.   MATRIX BIOLOGY

Notch Signaling Mediates Secondary Senescence

(2019) Yee Voan Teo et al.   Cell Reports

p16INK4A-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation

(2019) Takako S. Chikenji et al.   EBioMedicine

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

(2019) Raquel Buj et al.   Cell Reports

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

Integrated genomic and immunophenotypic classification of pancreatic cancer reveals three distinct subtypes with prognostic/predictive significance

(2018) Martin Wartenberg et al.   CLINICAL CANCER RESEARCH

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

(2018) Aled J. Parry et al.   Nature Communications

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

(2018) Carl Morrison et al.   Journal for ImmunoTherapy of Cancer

Efficacy of novel immunotherapy regimens in patients with metastatic melanoma with germline CDKN2A mutations

(2018) Hildur Helgadottir et al.   JOURNAL OF MEDICAL GENETICS

SASP regulation by noncoding RNA

(2017) Amaresh C. Panda et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models

(2017) William K. Decker et al.   Frontiers in Immunology

Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses

(2017) Mizuho Sakaki et al.   PLoS One

Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations

(2016) David M. Roy et al.   CANCER CELL

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

(2016) David Balli et al.   CLINICAL CANCER RESEARCH

Controlling secretion to limit chemoresistance

(2016) Athena Georgilis et al.   GENES & DEVELOPMENT

MLL1 is essential for the senescence-associated secretory phenotype

(2016) Brian C. Capell et al.   GENES & DEVELOPMENT

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

(2016) Katherine M. Aird et al.   JOURNAL OF CELL BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Reorganization of chromosome architecture in replicative cellular senescence

(2016) Steven W. Criscione et al.   Science Advances

mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation

(2015) William Damsky et al.   CANCER CELL

Nucleotide metabolism, oncogene-induced senescence and cancer

(2015) Katherine M. Aird et al.   CANCER LETTERS

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Global Reorganization of the Nuclear Landscape in Senescent Cells

(2015) Tamir Chandra et al.   Cell Reports

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

(2015) Tomohisa Hayakawa et al.   PLoS One

Copy Number Loss of the Interferon Gene Cluster in Melanomas Is Linked to Reduced T Cell Infiltrate and Poor Patient Prognosis

(2014) Peter S. Linsley et al.   PLoS One

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The ARF tumor suppressor: Structure, functions and status in cancer

(2010) Peggy Ozenne et al.   INTERNATIONAL JOURNAL OF CANCER

Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases

(2010) Gayani Nadika Pitiyage et al.   JOURNAL OF PATHOLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

JDP2 (Jun Dimerization Protein 2)-deficient Mouse Embryonic Fibroblasts Are Resistant to Replicative Senescence

(2009) Koji Nakade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

(2009) V K Goel et al.   ONCOGENE

p16INK4a-induced senescence is disabled by melanoma-associated mutations

(2008) Sebastian Haferkamp et al.   AGING CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

(2008) A. Swarbrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY