Article
Oncology
Juan L. Lopez-Canovas, Mercedes del Rio-Moreno, Helena Garcia-Fernandez, Juan M. Jimenez-Vacas, M. Trinidad Moreno-Montilla, Marina E. Sanchez-Frias, Victor Amado, Fernando L-Lopez, Marcos F. Fondevila, Ruben Ciria, Irene Gomez-Luque, Javier Briceno, Ruben Nogueiras, Manuel de la Mata, Justo P. Castano, Manuel Rodriguez-Peralvarez, Raul M. Luque, Manuel D. Gahete
Summary: Studies found that SF3B1 is overexpressed in hepatocellular carcinoma and is associated with tumor aggressiveness, oncogenic splicing variants expression, and decreased overall survival. Inhibition of SF3B1 genetically and/or pharmacologically may represent a promising novel therapeutic strategy.
Article
Immunology
Jose M. Rodrigo-Munoz, Marta Gil-Martinez, Clara Lorente-Sorolla, Raquel Garcia-Latorre, Marcela Valverde-Monge, Santiago Quirce, Joaquin Sastre, Victoria del Pozo
Summary: MicroRNA miR-144-3p is identified as a potential diagnostic biomarker for severe asthma, as its expression is associated with the severity of the disease and corticosteroid treatment. It is increased in asthmatic lungs and serum, correlating with blood eosinophilia and genes involved in asthma pathophysiology. This miRNA shows promise as a novel biomarker for severe asthma previously treated with higher doses of corticosteroids.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Briana N. James, Cynthia Weigel, Christopher D. Green, Ryan D. R. Brown, Elisa N. D. Palladino, Anuj Tharakan, Sheldon Milstien, Richard L. Proia, Rebecca K. Martin, Sarah Spiegel
Summary: Genome-wide association studies have shown that ORMDL3 is associated with asthma severity. The effects of ORMDL3 overexpression on sphingolipid synthesis and neutrophil inflammation were examined in a preclinical mouse model of severe asthma. The findings suggest a novel connection between ORMDL3, sphingolipid levels, IL-17, and neutrophil recruitment into the lung.
Article
Respiratory System
Prabuddha S. Pathinayake, David W. Waters, Kristy S. Nichol, Alexandra C. Brown, Andrew T. Reid, Alan Chen-Yu Hsu, Jay C. Horvat, Lisa G. Wood, Katherine J. Baines, Jodie L. Simpson, Peter G. Gibson, Philip M. Hansbro, Peter A. B. Wark
Summary: Research demonstrates that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are associated with disease severity and inflammatory phenotype in asthma.
Review
Allergy
Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Kian Fan Chung, Bernard Clot, Martine Collaud Coen, Gennaro D. Amato, Athanasios Damialis, Javier Dominguez-Ortega, Carmen Galan, Stefanie Gilles, Stephen Holgate, Mohamed Jeebhay, Stelios Kazadzis, Nikolaos G. Papadopoulos, Santiago Quirce, Joaquin Sastre, Fiona Tummon, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Pablo Alonso-Coello, Carlos Canelo-Aybar, Yahveth Cantero-Fortiz, David Rigau, Josefina Salazar, Francisca Verdugo-Paiva, Marek Jutel, Cezmi A. Akdis, Ioana Agache
Summary: This study aimed to investigate the impact of pollen exposure on asthma exacerbations and found that outdoor pollen exposure may have an effect on asthma exacerbation, particularly in children under 18 years of age. Further research is needed to evaluate the effects of pollen on asthma exacerbation, considering factors such as pollen sensitization, hay fever, air pollution, green spaces, and pre-existing medications, in order to improve preventive measures.
Article
Genetics & Heredity
Helena M. P. Teixeira, Alvaro A. Cruz, Talita S. Jesus, Maria B. R. de Santana, Marinalva S. Jesus, Rafaela Tugores, Wedson S. Araujo, Rebeca C. C. Reis, Gabriela P. Pinheiro, Camila A. Figueiredo, Ryan S. Costa
Summary: In this study, researchers investigated the association between two variants (rs2601796 and rs2532019) in the ADCY9 gene and asthma and lung function. They found that the rs2601796 variant was associated with worse asthma outcomes, including higher asthma severity, obstruction, and reduced responsiveness to bronchodilators. Individuals with this variant also had lower expression of ADCY9 in the lungs and blood. The rs2532019 variant also downregulated ADCY9 gene expression but did not show significant association with asthma severity or lung function.
Article
Allergy
Na Young Kim, Eun Shin, Sun-Ju Byeon, Seok Jin Hong, Sung Hun Kang, Taehoon Lee, Tae-Bum Kim, Jeong-Hee Choi
Summary: This study investigated the role of zonulin in the pathogenesis of severe asthma. The results showed that serum zonulin levels were significantly higher in patients with severe asthma and correlated with lung function. This suggests that zonulin may play an important role in the development of severe asthma, and serum zonulin could be a potential biomarker for severe asthma.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Noga Arwas, Sharon Uzan Shvartzman, Aviv Goldbart, Romi Bari, Itai Hazan, Amir Horev, Inbal Golan Tripto
Summary: Asthma is a common chronic respiratory disease in children, and there is a lack of data on the association of neutrophil-to-lymphocyte ratio (NLR) with acute asthma exacerbations. This cross-sectional study included children aged 2-18 years who visited the emergency department (ED) for asthma exacerbation between 2016 and 2021. The study found that NLR upon admission was associated with the severity of asthma exacerbation and higher chances of hospitalization among children in the ED.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Rory Chan, Chris RuiWen Kuo, Sunny Jabbal, Brian J. Lipworth
Summary: Eosinophil depletion leads to clinically meaningful attenuation of airway hyperresponsiveness in patients with severe uncontrolled asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Psychiatry
Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten R. Muller-Vahl, Manfred Stuhrmann, Yves Dion, Guy A. Rouleau, Harald Aschauer, Mara Stamenkovic, Monika Schloegelhofer, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Noethen, Johannes Hebebrand, Anke Hinney, Robert A. King, Thomas V. Fernandez, Csaba Barta, Zsanett Tarnok, Peter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L. Budman, Renata Rizzo, Gholson J. Lyon, William M. McMahon, James R. Batterson, Danielle C. Cath, Irene A. Malaty, Michael S. Okun, Cheston Berlin, Douglas W. Woods, Paul C. Lee, Joseph Jankovic, Mary M. Robertson, Donald L. Gilbert, Lawrence W. Brown, Barbara J. Coffey, Andrea Dietrich, Pieter J. Hoekstra, Samuel Kuperman, Samuel H. Zinner, Michael Wagner, James A. Knowles, A. Jeremy Willsey, Jay A. Tischfield, Gary A. Heiman, Nancy J. Cox, Nelson B. Freimer, Benjamin M. Neale, Lea K. Davis, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Peristera Paschou, Roger Kurlan, James F. Leckman, Jan H. Smit, Anastasios Konstantinidis, Tomasz Wolanczyk, Lawrence Brown, Keun-Ah Cheon, Blanca Garcia-Delgar, Dorothy E. Grice, Julie Hagstrom, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Bennett L. Leventhal, Marcos Madruga-Garrido, Pablo Mir, Astrid Morer, Alexander Muenchau, Kerstin J. Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song
Summary: Through genome-wide analysis, pathways underlying the neurobiology of Tourette syndrome have been elucidated, revealing associations with gene sets related to neuronal and glial functions. The study reinforces previous findings while also providing new insights into the neurobiology of TS.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Oncology
Jiaying Wang, Conghui Wang, Yang Li, Mingyue Li, Tingjia Zhu, Zhangjin Shen, Hui Wang, Weiguo Lv, Xinyu Wang, Xiaodong Cheng, Xing Xie
Summary: Exosomal miR-92b-3p from ovarian cancer cells modulates tumor-associated angiogenesis by targeting SOX4. Engineered exosomes with overexpressed miR-92b-3p demonstrate stronger anti-angiogenesis and antitumor effects compared to parental exosomes, both alone and in combination with Apatinib.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tania D. F. Costa, Staffan Stromblad
Summary: The overexpression of PAK4 in cancer has been found to be a significant factor, making it a suitable target for cancer therapy development.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Zhou, Ning Zhang, Wei Zhang, Caiju Lu, Fei Xu
Summary: The study found that YAP, HIF-1α, and miR-182 were upregulated in peripheral blood mononuclear cells from patients with asthma, while EGR2 was downregulated. The upregulation of YAP and HIF-1α promoted the expression of miR-182, which in turn inhibited EGR2 and enhanced Th17 cell differentiation, worsening asthma and lipid metabolism dysfunction.
CELL AND BIOSCIENCE
(2021)
Article
Allergy
Denisa Ferastraoaru, Golda Hudes, Elina Jerschow, Sunit Jariwala, Merhunisa Karagic, Gabriele de Vos, David Rosenstreich, Manish Ramesh
Summary: In asthmatics with COVID-19, pre-existing eosinophilia is associated with lower risk of hospital admission, while development of eosinophilia during hospitalization is linked to decreased mortality. Eosinophil levels before admission influence trends during hospitalization, with a Th2-asthma phenotype potentially predicting reduced COVID-19 morbidity and mortality.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Leonard B. Bacharier, Jorge F. Maspero, Constance H. Katelaris, Alessandro G. Fiocchi, Remi Gagnon, Ines de Mir, Neal Jain, Lawrence D. Sher, X. Mao, D. Liu, Yi Zhang, Asif H. Khan, Upender Kapoor, Faisal A. Khokhar, Paul J. Rowe, Yamo Deniz, Marcella Ruddy, Elizabeth Laws, Naimish Patel, David M. Weinreich, George D. Yancopoulos, Nikhil Amin, Leda P. Mannent, David J. Lederer, Megan Hardin
Summary: This study showed that among children aged 6 to 11 with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations, better lung function and asthma control compared to those who received placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Allergy
Efthymia Theofani, Maria Semitekolou, Konstantinos Samitas, Annie Mais, Ioanna E. Galani, Vasiliki Triantafyllia, Joanna Lama, Ioannis Morianos, Athanasios Stavropoulos, Se-Jin Jeong, Evangelos Andreakos, Babak Razani, Nikoletta Rovina, Georgina Xanthou
Summary: This study investigates the effects of autophagy and its master regulator, transcription factor EB (TFEB), on monocyte responses in asthmatic individuals.
Article
Respiratory System
Maria Sparreman Mikus, Johan Kolmert, Lars Andersson, Jorgen Ostling, Richard G. Knowles, Cristina Gomez, Magnus Ericsson, John-Olof Thorngren, Payam Emami Khoonsari, Barbro Dahlen, Maciej Kupczyk, Bertrand De Meulder, Charles Auffray, Per S. Bakke, Bianca Beghe, Elisabeth H. Bel, Massimo Caruso, Pascal Chanez, Bo Chawes, Stephen J. Fowler, Mina Gaga, Thomas Geiser, Mark Gjomarkaj, Ildiko Horvath, Peter H. Howarth, Sebastian L. Johnston, Guy Joos, Norbert Krug, Paolo Montuschi, Jacek Musial, Ewa Nizankowska-Mogilnicka, Henric K. Olsson, Alberto Papi, Klaus F. Rabe, Thomas Sandstrom, Dominick E. Shaw, Nikolaos M. Siafakas, Mathias Uhlen, John H. Riley, Stewart Bates, Roelinde J. M. Middelveld, Craig E. Wheelock, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Peter Nilsson, Sven-Erik Dahlen, Anna James
Summary: This study aimed to identify plasma biomarkers associated with asthma phenotypes by analyzing the samples from two well-characterized cohorts of severe and mild-to-moderate asthmatics. The results revealed several proteins that were significantly different between severe and mild-to-moderate asthmatics, and treatment with oral corticosteroids reduced the levels of these proteins. However, differences in protein levels between severe and mild-to-moderate asthmatics remained even after correction for corticosteroid use.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Allergy
Maria Kallieri, Eleftherios Zervas, Evangelia Fouka, Konstantinos Porpodis, Marija Hadji Mitrova, Eleni Tzortzaki, Michael Makris, Maria Ntakoula, Andriana I. Papaioannou, Panagiotis Lyberopoulos, Katerina Dimakou, Sofia Koukidou, Sevasti Ampelioti, Anastasia Papaporfyriou, Konstantinos Katsoulis, Maria Kipourou, Nikoletta Rovina, Katerina Antoniou, Stylianos Vittorakis, Petros Bakakos, Paschalis Steiropoulos, Katerina Markopoulou, Panteleimon Avarlis, Ilias C. Papanikolaou, Miltiadis Markatos, Eleni Gaki, Konstantinos Samitas, Konstantinos Glynos, Spyros A. Papiris, Despoina Papakosta, Nikolaos Tzanakis, Mina Gaga, Konstantinos Kostikas, Stelios Loukides
Article
Allergy
Andriana I. Papaioannou, Evangelia Fouka, Nikolaos Tzanakis, Katerina Antoniou, Konstantinos Samitas, Eleftherios Zervas, Konstantinos Kostikas, Konstantinos Bartziokas, Konstantinos Porpodis, Despoina Papakosta, Argyris Tzouvelekis, Irini Gerogianni, Ourania Kotsiou, Michael Makris, Nikoletta Rovina, Garyfallia Vlachou, Miltiadis Markatos, Stelios Vittorakis, Konstantinos Katsoulis, Ilias Papanikolaou, Andreas Afthinos, Paraskevi Katsaounou, Paschalis Steiropoulos, Dimitrios Latsios, Katerina Dimakou, Sofia Koukidou, Georgios Hillas, Stavros Tryfon, Maria Kallieri, Athina Georgopoulou, Pantelis Avarlis, Petros Bakakos, Katerina Markopoulou, Eleni Gaki, Asimina Paspala, Zacharoula Kyriakaki, Konstantinos I. Gourgoulianis, Spyridon Papiris, Stelios Loukides
Summary: The study found that during the COVID-19 pandemic, severe asthma patients treated with biologics were not at a higher risk of SARS-CoV-2 infection compared to the general population, and the use of biologic treatments for severe asthma during the pandemic did not seem to be associated with adverse outcomes from severe COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Respiratory System
Stylianos K. Vittorakis, Georgia Giannakopoulou, Konstantinos Samitas, Eleftherios Zervas
Summary: A 26-year-old female with steroid dependent eosinophilic asthma and nasal polyps successfully controlled her symptoms with mepolizumab treatment for 17 months. However, she discontinued the biologic treatment due to pregnancy efforts, which resulted in frequent exacerbations and daily symptoms despite other treatments. After re-initiating mepolizumab, her asthma control improved and she was able to gradually withdraw from steroids within 2 months. The patient became pregnant and had a successful delivery while using mepolizumab during pregnancy.
RESPIRATORY MEDICINE CASE REPORTS
(2023)
Editorial Material
Respiratory System
Evangelia Fouka, Konstantinos Samitas, Petros Bakakos
Review
Respiratory System
Petros Bakakos, Evangelia Fouka, Petros Galanakis, Konstantinos Katsoulis, Konstantinos Kostikas, Stelios Loukides, Nikolas Mathioudakis, Konstantinos Porpodis, Konstantinos Samitas, Paschalis Steiropoulos, Eleftherios Zervas
Summary: The aim of this study is to assess the prevalence and predictors of Type 2 low severe asthma (SA) in Greece and depict the patient profile, clinical features, treatment patterns, and disease burden. The study will use clinical and patient-reported outcomes (PROs) to collect data on asthma symptom control, quality of life, anxiety, depression, work productivity, and activity impairment. The evidence generated by this study will provide insight into the prevalence and disease burden of Type 2 low SA, which can inform healthcare decisionmaking.
Article
Respiratory System
Johannes A. Kroes, Rafael Alfonso-Cristancho, Aruna T. Bansal, Emmanuelle Berret, Kristina Bieksiene, Arnaud Bourdin, Luisa Brussino, Diogo Canhoto, Cristina Cardini, Gulfem Celik, Zsuzsanna Csoma, Barbro Dahlen, Ebru Damadoglu, Katrien Eger, Lisa Gauquelin, Bilun Gemicioglu, Ozlem Goksel, Sophie Graff, Enrico Heffler, Hendrik B. Hofstee, Peter Howarth, Rupert W. Jakes, Fabienne Jaun, Virginija Kalinauskaite-Zukauske, Peter Kopac, Namhee Kwon, Claudia C. Loureiro, Victor Lozoya Garcia, Matthew Masoli, Mariana Paula Rezelj, Luis Perez De Llano, Sanja Popovic-Grle, David Ramos-Barbon, Ana Sa Sousa, Konstantinos Samitas, Florence Schleich, Concetta Sirena, Sabina Skrgat, Eleftherios Zervas, George Zichnalis, Elisabeth H. Bel, Jacob K. Sont, Simone Hashimoto, Anneke Ten Brinke
Summary: The study "Real-world effectiveness of mepolizumab in patients with severe heterogeneous asthma" aimed to harmonize data from 10 national severe asthma registries and evaluate the effectiveness of mepolizumab treatment. The results demonstrated significant reductions in frequent exacerbations and maintenance oral glucocorticoid use, consistent with previous studies, which paves the way for future real-world studies in Europe using patient-level data.
Article
Respiratory System
Alberto Papi, Diogenes S. Ferreira, Ioana Agache, Eugenio Baraldi, Richard Beasley, Guy Brusselle, Courtney Coleman, Mina Gaga, Carolina Maria Gotera Rivera, Erik Melen, Ian D. Pavord, Deborah Penate Gomez, Daniel Schuermans, Antonio Spanevello, Thomy Tonia, Florence Schleich
Summary: Recent clinical trials have shown that using as-needed ICS/formoterol could be a potential treatment option for mild asthma. The European Respiratory Society's Task Force has provided evidence-based recommendations, suggesting that adults with mild asthma should use as-needed ICS/formoterol instead of regular ICS maintenance treatment plus as-needed SABA, while adolescents can choose either as-needed ICS/formoterol or ICS maintenance treatment plus as-needed SABA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Anne-Noelle Frix, Liam G. Heaney, Barbro Dahlen, Florin Mihaltan, Svetlana Sergejeva, Sanja Popovic-Grle, Vratislav Sedlak, Lauri Lehtimaki, Arnaud Bourdin, Stephanie Korn, Eleftherios Zervas, Zsuzsanna Csoma, Dora Ludviksdottir, Marcus Butler, Giorgio Walter Canonica, Ineta Grisle, Kristina Bieksiene, Anneke Ten Brinke, Piotr Kuna, Claudia Chaves Loureiro, Natalia M. Nenasheva, Zorica Lazic, Sabina Skrgat, David Ramos-Barbon, Joerg Leuppi, Bilun Gemicioglu, Apostolos Bossios, Celeste M. Porsbjerg, Elisabeth H. Bel, Ratko Djukanovic, Renaud Louis
Summary: Our study revealed significant heterogeneity in the use of asthma biologics across Europe. Further investigation is needed to assess the impact of this heterogeneity on clinical outcomes relevant to patients and healthcare services.
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Giannis Mountzios, Petros Christopoulos, Thomas Papastergiou, Mariam Elshiaty, Lea Daniello, Elefterios Zervas, Sofia Agelaki, Epaminondas Samantas, Adamantia Nikolaidi, Ilias Athanasiadis, Sofia Baka, Konstantinos Syrigos, Athina Christopoulou, Evangelos Lianos, Konstantinos Samitas, Nikolaos Tsoukalas, Eleni-Isidora Perdikouri, George Oikonomopoulos, Anastasia Kottorou, Foteini Kalofonou, Thomas Makatsoris, Angelos Koutras, Vasileios Megalooikonomou, Haralabos Kalofonos
Summary: This study validates the clinical value of the Patras Immunotherapy Score (PIOS) in patients with advanced non-small-cell lung cancer (aNSCLC) treated with anti-PD-1 monotherapy. PIOS was found to be associated with improved progression-free survival and overall survival, and it can be used as a predictor of immunotherapy efficacy and prognosis.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Respiratory System
Katrien Eger, Dora Paroczai, Alison Bacon, Florence Schleich, Svetlana Sergejeva, Arnaud Bourdin, Isabelle Vachier, Eleftherios Zervas, Konstantinos Katsoulis, Dimosthenis Papapetrou, Konstantinos Kostikas, Zsuzsanna Csoma, Enrico Heffler, Giorgio Walter Canonica, Ineta Grisle, Kristina Bieksiene, Jolita Palacionyte, Anneke Ten Brinke, Simone Hashimoto, Frank W. J. M. Smeenk, Gert-Jan Braunstahl, Simone van der Sar, Florin Mihaltan, Natalia Nenasheva, Marina Peredelskaya, Biljana Zvezdin, Ivan Cekerevac, Sanja Hromis, Vojislav Cupurdija, Zorica Lazic, Branislava Milenkovic, Sanja Dimic-Janjic, Valentyna Yasinska, Barbro Dahlen, Apostolos Bossios, Nikolaos Lazarinis, David Aronsson, Arne Egesten, Abul Kashem Mohammad Munir, Lars Ahlbeck, Christer Janson, Sabina Skrgat, Natalija Edelbaher, Joerg Leuppi, Fabienne Jaun, Jochen Rudiger, Nikolay Pavlov, Pietro Gianella, Reta Fischer, Florian Charbonnier, Rekha Chaudhuri, Steven James Smith, Simon Doe, Michelle Fawdon, Matthew Masoli, Liam Heaney, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Olivia Fulton, Betty Frankemolle, Toni Gibson, Karen Needham, Peter Howarth, Ratko Djukanovic, Elisabeth Bel, Michael Hyland
Summary: During the COVID-19 pandemic, video/phone consultations and home administration of biologics were common in the care of severe asthma. Most patients were satisfied with these changes, and many doctors expect them to continue in the future care of severe asthma.