Article
Respiratory System
Naoya Tanabe, Kaoruko Shimizu, Kunihiko Terada, Susumu Sato, Masaru Suzuki, Hiroshi Shima, Akira Oguma, Tsuyoshi Oguma, Satoshi Konno, Masaharu Nishimura, Toyohiro Hirai
Summary: The study found that the CT-based AD COPD subtype is not strongly associated with small airway disease, but is linked to central airway size and asthma history. In contrast, the ED subtype is associated with small airway dysfunction but not with central airway size.
Article
Medicine, General & Internal
Andrzej Obojski, Mateusz Patyk, Urszula Zaleska-Dorobisz
Summary: This study found that the thickness of the bronchial wall was greater in the SA-PAL group than in the COPD group, with the lowest lung density observed in the SA-PAL group and a higher percentage of low-attenuation volume compared to the healthy volunteer group. Severe asthma with persistent airflow limitation and COPD become similar in terms of functional and morphological dimensions over time, both showing emphysema qualities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Thuy D. Do, Stephan Skornitzke, Uta Merle, Maximilian Kittel, Stefan Hofbaur, Claudius Melzig, Hans-Ulrich Kauczor, Mark O. Wielpuetz, Oliver Weinheimer
Summary: Fully automatic lung quantification based on spectral CT and laboratory parameters can be used for prognostic prediction in COVID-19 pneumonia, and it can predict the need for invasive ventilation in patients.
Article
Respiratory System
Jisoo Park, Eun-Kyung Kim, Se Hee Lee, Mi-Ae Kim, Jung-Hyun Kim, Sang Min Lee, Jae Seung Lee, Yeon-Mok Oh, Sang -Do Lee, Ji-Hyun Lee
Summary: By quantitatively measuring the emphysema distribution in COPD patients, it can predict treatment response and exacerbation. The LD group showed more prominent airway involvement, which may result in more frequent exacerbations and a marked reduction in lung function.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Respiratory System
Chunrui Zou, Frank Li, Jiwoong Choi, Babak Haghighi, Sanghun Choi, Prathish K. Rajaraman, Alejandro P. Comellas, John D. Newell, Chang Hyun Lee, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Meilan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric C. Kleerup, Fernando J. Martinez, Wanda O'Neal, Robert Paine, Stephen I. Rennard, Benjamin M. Smith, Prescott G. Woodruff, Eirc A. Hoffman, Ching-Long Lin
Summary: Quantitative computed tomography (qCT) imaging-based cluster analysis identified four stable clusters in former smokers with COPD, each exhibiting unique progression patterns such as rapid progression, decrease, and expansion. Longitudinal data helps identify how patients progress over time within the same cluster, refining the understanding of disease progression.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Amir Moslemi, Konstantina Kontogianni, Judith Brock, Susan Wood, Felix Herth, Miranda Kirby
Summary: This study aimed to determine the optimal subset of CT imaging features for differentiating COPD and asthma using machine learning. The results showed that COPD and asthma can be differentiated with moderate-to-high accuracy using a subset of only seven CT features.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taeyoung Yun, Hyewon Choi, Hyungjin Kim, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Jin Mo Goo, Young Tae Kim
Summary: This study evaluated the association between visual emphysema on preoperative CT and respiratory complications and prolonged air leak in smokers undergoing lobectomy. The results showed an association between visual emphysema and PAL and respiratory complications.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, Maria Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Mueller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balazs Dome, Janos Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernandez-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock
Summary: The study identified significant differences in lung gene expression between male and female COPD patients, revealing the involvement of different types of leukocytes in the pathophysiology of the disease in different subtypes of COPD patients.
SCIENTIFIC REPORTS
(2021)
Article
Medical Informatics
Muhammad F. A. Chaudhary, Eric A. Hoffman, Junfeng Guo, Alejandro P. Comellas, John D. Newell Jr, Prashant Nagpal, Spyridon Fortis, Gary E. Christensen, Sarah E. Gerard, Yue Pan, Di Wang, Fereidoun Abtin, Igor Z. Barjaktarevic, R. Graham Barr, Surya P. Bhatt, Sandeep Bodduluri, Christopher B. Cooper, Lisa Gravens-Mueller, MeiLan K. Han, Ella A. Kazerooni, Fernando J. Martinez, Martha G. Menchaca, Victor E. Ortega, Robert Paine III, Joyce D. Schroeder, Prescott G. Woodruff, Joseph M. Reinhardt
Summary: This study aimed to develop and validate quantitative CT-based models for predicting severe exacerbations of COPD. The results showed that CT-based prediction models can be used to identify high-risk patients with COPD. The newly identified CT biomarkers could potentially enable investigation into underlying disease mechanisms responsible for exacerbations.
LANCET DIGITAL HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Chen, E. Emami, C. Kauffmann, P. Rompre, F. Almeida, M. Schmittbuhl, P. van der Stelt, S. Ge, G. Lavigne, N. Huynh
Summary: The study aimed to examine how the anatomic characteristics of the upper airway can influence the effect of wearing dentures on the sleep of edentulous elders with untreated sleep apnea. The results showed a correlation between upper airway characteristics and the aggravation of respiratory variables caused by wearing dentures at night.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jorine E. Hartman, Gerard J. Criner, William H. Moore, Eva M. van Rikxoort, Frank C. Sciurba, Pallav L. Shah, Rozemarijn Vliegenthart, Jorrit B. A. Welling, Dirk-Jan Slebos
Summary: This study aimed to investigate the level of agreement among expert reviewers of HRCT-scans in emphysema patients and compare with QCT software. The results showed that the interobserver agreement among five expert CT-assessors was fair to moderate when evaluating the most destructed lobe, with higher consistency in matching QCT determination. The inclusion of more than one CT-reviewer supported by QCT measurements is recommended for optimal patient selection in bronchoscopic lung volume reduction treatment.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlos H. Martinez, Yuka Okajima, Andrew Yen, Diego J. Maselli, Pietro Nardelli, Farbord Rahaghi, Kendra Young, Gregory Kinney, Charles Hatt, Craig Galban, George R. Washko, MeiLan Han, Raul San Jose Estepar, Alejandro A. Diaz
Summary: This study assessed the relationship between chronic obstructive pulmonary disease (COPD) and bronchiectasis in smokers, revealing that smokers with radiographic bronchiectasis have an increased burden of emphysema and lower airflow and exercise capacity.
ACADEMIC RADIOLOGY
(2021)
Article
Medicine, General & Internal
Placido Gomes, Helder Novais e Bastos, Andre Carvalho, Andre Lobo, Alan Guimaraes, Rosana Souza Rodrigues, Walter Araujo Zin, Alysson Roncally S. Carvalho
Summary: This study evaluated the association between emphysema extent and regional distribution quantified by chest CT with clinical and functional severity in COPD patients. Results showed that emphysema volume should be referenced to predicted lung volume, not measured lung volume, for assessment. Pulmonary function impairments were greater in patients with higher emphysema volumes and more homogenous distribution of emphysema.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Marieke C. van der Molen, Jorine E. Hartman, Karin Klooster, Huib A. M. Kerstjens, Joost van Melle, Tineke P. Willems, Dirk-Jan Slebos
Summary: A retrospective analysis of 255 COPD patients found low prevalence of PH and systolic left ventricle dysfunction. The study suggests that the CT-derived PA:A ratio >1 is not an effective screening tool for PH, while a PA diameter >30 mm may serve as an alternative screening method for PH in this patient group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Zhang, Beibei Jiang, Hendrik Joost Wisselink, Rozemarijn Vliegenthart, Xueqian Xie
Summary: By utilizing chest CT images, a deep convolutional neural network model was established to accurately infer lung function and diagnose COPD, showing significantly higher accuracy compared to traditional quantitative CT methods.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
David Dora, Christopher Rivard, Hui Yu, Shivaun Lueke Pickard, Viktoria Laszlo, Tunde Harko, Zsolt Megyesfalvi, Csongor Gerdan, Elek Dinya, Konrad Hoetzenecker, Fred R. Hirsch, Zoltan Lohinai, Balazs Dome
Summary: This study characterizes the microenvironment of SCLC and identifies potential therapeutic targets by analyzing the expression patterns of SCLC subtype markers and immune checkpoints. The results show that STING and MHCII are expressed in SCLC, and increased immune infiltration and STING expression are associated with better prognosis. These findings suggest that STING may be a promising therapeutic target for limited-stage SCLC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Allergy
Julian Nehrig, Nicole Grosse, Ilja P. P. Hohenfeld, Jens M. M. Hohlfeld, Philipp Badorrek
Summary: This study tested a new nasal spray (AM-301) for its ability to reduce symptoms of grass pollen allergy. The results showed that AM-301 was noninferior to the established barrier method (HPMC) in reducing nasal symptoms. Both AM-301 and HPMC had a persistent protective effect and were safe.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Christian Domingo, Dave Singh
Summary: Short-acting beta(2) agonists (SABAs) have been commonly used for asthma treatment since the 1950s. However, poor adherence to regular inhaled corticosteroid (ICS)-based maintenance therapy often leads to excessive use of SABAs and negative outcomes. Current treatment guidelines lack consensus on the use of SABAs, and some suggest using ICS-formoterol as an alternative reliever therapy. This article examines the pharmacology and current use of SABAs, discusses the importance of regular ICS dosing, and evaluates the evidence supporting changes in reliever treatment recommendations.
ADVANCES IN THERAPY
(2023)
Article
Respiratory System
Raphael Borie, Caroline Kannengiesser, Katerina Antoniou, Francesco Bonella, Bruno Crestani, Aurelie Fabre, Antoine Froidure, Liam Galvin, Matthias Griese, Jan C. Grutters, Maria Molina-Molina, Venerino Poletti, Antje Prasse, Elisabetta Renzoni, Jasper van der Smagt, Coline H. M. van Moorsel
Summary: The discovery of gene mutations that cause pulmonary fibrosis confirms the genetic predisposition to this condition. While genetic sequencing is already part of routine clinical practice for familial pulmonary fibrosis cases in some countries, it has not been widely incorporated into interstitial lung disease services and lacks international consensus.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Gail M. Gauvreau, Jens M. Hohlfeld, J. Mark FitzGerald, Louis-Philippe Boulet, Donald W. Cockcroft, Beth E. Davis, Stephanie Korn, Oliver Kornmann, Richard Leigh, Irvin Mayers, Henrik Watz, Sarah S. Grant, Monish Jain, Maciej Cabanski, Peter E. Pertel, Ieuan Jones, Jean R. Lecot, Hui Cao, Paul M. O'Byrne
Summary: The study evaluated the efficacy and safety of ecleralimab, an inhaled neutralizing antibody fragment against TSLP, in subjects with mild atopic asthma. The results showed that ecleralimab significantly reduced allergen-induced bronchoconstriction and airway inflammation, and it was safe in subjects with mild atopic asthma.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Toby M. Maher, Paul Ford, Kevin K. Brown, Ulrich Costabel, Vincent Cottin, Sonye K. Danoff, Irene Groenveld, Eric Helmer, R. Gisli Jenkins, Julie Milner, Geert Molenberghs, Bjorn Penninckx, Matthew J. Randall, Bernt Van den Blink, Ann Fieuw, Charlotte Vandenrijn, Sanda Rocak, Ineke Seghers, Lixin Shao, Amit Taneja, Garrit Jentsch, Timothy R. Watkins, Wim A. Wuyts, Michael Kreuter, Nadia Verbruggen, Niyati Prasad, Marlies S. Wijsenbeek
Summary: This study aimed to assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with idiopathic pulmonary fibrosis (IPF). The study found that ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Respiratory System
Jurgen Behr, Melanie Berger, Torsten Gerriet Blum, Francesco Bonella, Julien Dinkel, Sven Glaeser, Lars Hagmeyer, Nikolaus Kneidinger, Dirk Koschel, Antje Prasse, Hortense Slevogt, Elvira Stacher-Priehse, Holger Woehrle, Michael Kreuter
Summary: The SARS-CoV-2 pandemic has had a significant impact on the diagnosis and treatment of ILDs. Viral pneumonias caused by the delta variant exacerbated pre-existing ILDs and led to the discovery of previously subclinical ILDs. The effect of SARS-CoV-2 infection on the progression of ILDs is unpredictable and poses challenges to medical professionals.
Article
Respiratory System
Juergen Behr, Francesco Bonella, Bjoern C. Frye, Andreas Guenther, Lars Hagmeyer, Joerg Henes, Philipp Klemm, Dirk Koschel, Michael Kreuter, Gabriela Leuschner, Dennis Nowak, Antje Prasse, Bernd Quadder, Helmut Sitter, Ulrich Costabel
Article
Medicine, Research & Experimental
Martin Kolb, Kevin R. Flaherty, Rafael S. Silva, Antje Prasse, Carlo Vancheri, Heiko Mueller, Kamila Sroka-Saidi, Athol U. Wells, INBUILD Trial Investigators
Summary: The study found that nintedanib consistently slowed the rate of decline in forced vital capacity (FVC) in patients with progressive pulmonary fibrosis. The effectiveness of nintedanib in reducing the progression of interstitial lung disease (ILD) was also consistent across subgroups based on different baseline characteristics. This supports the use of nintedanib as a treatment for progressive pulmonary fibrosis.
ADVANCES IN THERAPY
(2023)
Editorial Material
Critical Care Medicine
Dave Singh
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Jonas C. Schupp, Edward P. Manning, Maurizio Chioccioli, Jan C. Kamp, Leonard Christian, Changwan Ryu, Erica Herzog, Mark P. Kuehnel, Antje Prasse, Naftali Kaminski, Danny D. Jonigk, Robert J. Homer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Peter Zannikos, Bhavna Solanki, Marc De Meulder, Philipp Badorrek, Jens M. M. Hohlfeld, Jaskaran Singh
Summary: The effects of nasal decongestant pretreatment in patients with allergic rhinitis and daily nasal corticosteroid administration in healthy subjects on nasal esketamine pharmacokinetics were evaluated in this study. The results showed that allergic rhinitis patients had slightly increased rate of esketamine absorption, but the impact on maximum concentration and area under the curve was small. The pharmacokinetics of esketamine was not affected by nasal decongestant or corticosteroid pretreatment. Nasal esketamine spray can be used by patients with allergic rhinitis without dose adjustment, and can also be administered 1 hour after using a nasal decongestant or corticosteroid.
CLINICAL PHARMACOKINETICS
(2023)
Correction
Pharmacology & Pharmacy
Peter Zannikos, Bhavna Solanki, Marc De Meulder, Philipp Badorrek, Jens M. Hohlfeld, Jaskaran Singh
CLINICAL PHARMACOKINETICS
(2023)
Editorial Material
Medicine, General & Internal
Jannik Ruwisch, Tobias Welte, Antje Prasse
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2023)
Article
Pharmacology & Pharmacy
Christina Gress, Jens Vogel-Claussen, Philipp Badorrek, Meike Mueller, Kathrin Hohl, Marilisa Konietzke, Tobias Litzenburger, Wolfgang Seibold, Abhya Gupta, Jens M. Hohlfeld
Summary: This study aimed to investigate the effect of BI 1026706 on inflammatory response in the LPS lung challenge model. The results showed that BI 1026706 did not reduce the number of inflammatory cells in the lungs and instead increased the extent of pulmonary edema.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2023)