The effect of bradykinin 1 receptor antagonist BI 1026706 on pulmonary inflammation after segmental lipopolysaccharide challenge in healthy smokers

A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases

(2022) Devasahayam Arokiar Balaya Rex et al.   MOLECULAR BIOLOGY REPORTS

Respiratory Viral and Bacterial Exacerbations of COPD—The Role of the Airway Epithelium

(2022) Michelle E. Love et al.   Cells

Bradykinin/bradykinin 1 receptor promotes brain microvascular endothelial cell permeability and proinflammatory cytokine release by downregulating Wnt3a

(2022) Linqiang Huang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Update in Chronic Obstructive Pulmonary Disease in 2020

(2021) Andy I Ritchie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation

(2020) Daniel Brooks et al.   EUROPEAN RESPIRATORY JOURNAL

Bradykinin 1 Receptor Antagonist BI1026706 Does Not Reduce Central Retinal Thickness in Center-Involved Diabetic Macular Edema

(2020) Gabriele E. Lang et al.   Translational Vision Science & Technology

Bacterial and viral infections and related inflammatory responses in Chronic Obstructive Pulmonary Disease

(2020) Silvestro Ennio D’Anna et al.   ANNALS OF MEDICINE

Noninvasive Monitoring of the Response of Human Lungs to Low‐Dose Lipopolysaccharide Inhalation Challenge Using MRI: A Feasibility Study

(2019) Agilo L. Kern et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

(2018) Naimish Patel et al.   International Journal of Chronic Obstructive Pulmonary Disease

Kinin B1 receptors as a therapeutic target for inflammation

(2017) Fatimunnisa Qadri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Experimental animal models for COPD: a methodological review

(2017) Vahideh Ghorani et al.   Tobacco Induced Diseases

Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice

(2016) Malarvizhi Gurusamy et al.   PHARMACOLOGICAL RESEARCH

Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease

(2015) Vandana Gupta et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Kinin B1 Receptor Antagonist BI113823 Reduces Acute Lung Injury*

(2015) Saeed Nasseri et al.   CRITICAL CARE MEDICINE

Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects

(2015) Dave Singh et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

(2015) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kinin B1 Receptor Inhibition With BI113823 Reduces Inflammatory Response, Mitigates Organ Injury, and Improves Survival Among Rats With Severe Sepsis

(2015) Priya Murugesan et al.   JOURNAL OF INFECTIOUS DISEASES

Quantification of Pulmonary Inflammation after Segmental Allergen Challenge Using Turbo-Inversion Recovery-Magnitude Magnetic Resonance Imaging

(2014) Jens Vogel-Claussen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Inhaled Endotoxin on Mucociliary Clearance and Airway Inflammation in Mild Smokers and Nonsmokers

(2014) William D. Bennett et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

A role for bradykinin in the development of anti-collagen antibody-induced arthritis

(2014) Zhanli Xie et al.   RHEUMATOLOGY

Anti-TNF inhibits the Airways neutrophilic inflammation induced by inhaled endotoxin in human

(2014) Olivier Michel et al.   BMC Pharmacology & Toxicology

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

Expression of vascular remodelling markers in relation to bradykinin receptors in asthma and COPD

(2013) Fabio L M Ricciardolo et al.   THORAX

Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development

(2013) Ole Janssen et al.   BMC Pulmonary Medicine

Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects

(2012) Raminder Aul et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers

(2012) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ocular Application of the Kinin B1 Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

(2012) Mylène Pouliot et al.   PLoS One

Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum

(2012) Stefan Röpcke et al.   PLoS One

Microbiological components in mainstream and sidestream cigarette smoke

(2012) Lennart Larsson et al.   Tobacco Induced Diseases

Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells

(2011) Sébastien Talbot et al.   PEPTIDES

Summary of the British Thoracic Society Guidelines for advanced diagnostic and therapeutic flexible bronchoscopy in adults

(2011) I. A. Du Rand et al.   THORAX

Effect of interferon-γ on inflammatory cytokine-induced bradykinin B1 receptor expression in human vascular cells

(2010) Gérémy Abdull Koumbadinga et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanism of cigarette smoke-induced kinin B1 receptor expression in rat airways

(2010) James Chi-Jen Lin et al.   PEPTIDES

Dual positive and negative regulation of GPCR signaling by GTP hydrolysis

(2009) Benjamin Smith et al.   CELLULAR SIGNALLING

Endotoxin Augments Myeloid Dendritic Cell Influx into the Airways in Patients with Allergic Asthma

(2008) Frank Schaumann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial

(2008) Jens M. Hohlfeld et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS