Article
Multidisciplinary Sciences
Sebastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier, Irwin Davidson
Summary: CHD4 regulates the expression of PADI1 and PADI3, affecting citrullination of the arginine residues of PKM2, leading to excessive glycolysis and reduced cell proliferation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lipeng Gan, Qilin Shangguan, Fang Zhang, Xiaomei Tong, Dandan Qi, Yan Zhao, Xin Ye
Summary: HBV infection downregulates LINC01010 expression, resulting in inhibition of cell proliferation and migration. The mechanism of action of LINC01010 primarily involves interfering with the formation of vimentin filaments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Xiaoming Wu, Tingting Jiang, Rui Huang, Xue Xiao
Summary: GAS8-AS1 is downregulated while lncRNA NEAT1 is upregulated in GBM patients. Alterations in the expression levels of GAS8-AS1 and NEAT1 can distinguish GBM patients from healthy controls. The expression of GAS8-AS1 and NEAT1 is inversely correlated in GBM patients.
BRAIN AND BEHAVIOR
(2021)
Article
Cell Biology
Rebekah Brooks, Judith Monzy, Bailey Aaron, Xue Zhang, Andrew Kossenkov, James Hayden, Frederick Keeney, David W. Speicher, Lin Zhang, Chi V. Dang
Summary: We identified ADIRF-AS1 as a circadian long non-coding RNA (lncRNA) that interacts with all components of the PBAF complex. ADIRF-AS1 partially regulates specific genes through modulation of PBAF and is associated with survival in human ccRCC.
Article
Cell Biology
Tianbin Chen, Qingyang Liang, Jialin Xu, Yanan Zhang, Yi Zhang, Liping Mo, Li Zhang
Summary: The study found that by regulating SDC1, miR-665 inhibits the effect of the lncRNA GAS5 on VSMCs. This could provide a new treatment strategy for aging-related cardiovascular diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Heng Zhang, Shao-Qiang Wang, Jie-Bo Zhu, Li-Na Wang, Hang Lin, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Summary: CALML3-AS1 is upregulated while BTNL9 is downregulated in NSCLC. Depletion of CALML3-AS1 inhibits malignant phenotypes, tumor growth, and liver metastasis in NSCLC. Mechanistically, ALKBH5 enhances the stability of CALML3-AS1 through m6A demethylation, while YTHDC2 destabilizes CALML3-AS1. Additionally, CALML3-AS1 represses BTNL9 transcription and expression through the recruitment of EZH2. Downregulation of BTNL9 counteracts the antitumor effects mediated by CALML3-AS1 in NSCLC.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Pengju Fan, Yongjie Wang, Jingjing Li, Man Fang
Summary: This study revealed that lncRNA PAPPA-AS1 may induce the development of HTS by upregulating TLR4 through interaction with TAF15. Silencing PAPPA-AS1 can suppress the proliferation of HTsFb cells and the expression of fibrosis markers.
MEDIATORS OF INFLAMMATION
(2021)
Article
Veterinary Sciences
Yufang Liu, Yulin Chen, Zuyang Zhou, Xiaoyun He, Lin Tao, Yanting Jiang, Rong Lan, Qionghua Hong, Mingxing Chu
Summary: GC proliferation is essential for ovulation in animals, and DENND1A is identified as a significant factor in polycystic ovary syndrome. The study demonstrates that chi-miR-324-3p inhibits GC proliferation by targeting DENND1A, as validated through various experiments.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Weiwei Zheng, Yingchang Guo, Guangtan Zhang, Junwei Bai, Yucheng Song, Xiaofei Song, Qinhui Zhu, Xuebin Bao, Gang Wu, Chao Zhang
Summary: By bioinformatic analysis, it was found that lncRNA BVES-AS1 was associated with poor prognosis in colorectal cancer (CRC) patients. BVES-AS1 was validated to encode a micro-peptide named BVES-AS1-201-50aa, which enhanced CRC cell viability and promoted migration and invasion through activation of the Src/mTOR signaling pathway.
Article
Oncology
Shuai Xue, Fengqin Lu, Chunhui Sun, Jingjing Zhao, Honghua Zhen, Xin Li
Summary: The study revealed that ZEB1-AS1 is upregulated and miR-23c is downregulated in HCC tissues and cell lines. Knockdown of ZEB1-AS1 inhibited the proliferation and invasion of HCC cells, and it was shown that miR-23c is a target of ZEB1-AS1.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Qingfu Su, Zhenliang Pan, Heyi Chen, Jiabi Chen, Yanmei Zhang, Wei Zhuang
Summary: This study reveals that RBM47 is downregulated in renal cell carcinoma (RCC) and its expression is negatively correlated with patient prognosis. RBM47 interferes with the interaction between HOXB-AS1 and p53 by directly binding with HOXB-AS1, leading to the activation of p53 signaling. RBM47 also shows a synergistic anticancer effect with sunitinib both in vivo and in vitro.
CELL DEATH DISCOVERY
(2023)
Article
Immunology
Wenjia Chai, Xiaolin Wang, Zhengjing Lu, Shihan Zhang, Wei Wang, Hui Wang, Chenghao Chen, Wei Yang, Haiyan Cheng, Huanmin Wang, Jun Feng, Shen Yang, Qiliang Li, Wenqi Song, Fang Jin, Hui Zhang, Yan Su, Jingang Gui
Summary: NK cell activation in neuroblastoma is regulated by the long noncoding RNA EPB41L4A-AS1, leading to suppressed glycolysis in NK cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yeong-Hwan Lim, Gwangho Yoon, Yeongseo Ryu, Dahee Jeong, Juhyun Song, Yong Sook Kim, Youngkeun Ahn, Hyun Kook, Young-Kook Kim
Summary: This study identified a macrophage-specific lncRNA, SUGCT-AS1, which is involved in the inflammatory response. Depletion of SUGCT-AS1 in M1 macrophages promoted the expression and secretion of proinflammatory cytokines and induced an inflammatory phenotype in vascular smooth muscle cells. The study also revealed the regulatory mechanism of SUGCT-AS1 through its interaction with hnRNPU and the alternative splicing of MALT1, a mediator of NF-κB signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jun Sun, Dong He, Yibing Fu, Rui Zhang, Hua Guo, Zhaojuan Wang, Yanan Wang, Taihong Gao, Yanbang Wei, Yuji Guo, Qi Pang, Qian Liu
Summary: The novel lncRNA ARST is significantly downregulated in gliomas, and overexpression of ARST suppresses vital cellular abilities in glioma cells, including cell growth, proliferation, migration, and invasion, ultimately reducing tumorigenicity in vivo. The tumor suppressive effects of ARST are mediated by direct binding to the glycolytic enzyme ALDOA, disrupting the interaction with actin cytoskeleton and altering the invasive properties of glioma cells. This highlights ARST as a potential target for glioma diagnosis, therapy, and prognosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Matthias S. Leisegang, Jasleen Kaur Bains, Sandra Seredinski, James A. Oo, Nina M. Krause, Chao-Chung Kuo, Stefan Guenther, Nevcin Senturk Cetin, Timothy Warwick, Can Cao, Frederike Boos, Judit Izquierdo Ponce, Shaza Haydar, Rebecca Bednarz, Chanil Valasarajan, Dominik C. Fuhrmann, Jens Preussner, Mario Looso, Soni S. Pullamsetti, Marcel H. Schulz, Hendrik R. A. Jonker, Christian Richter, Flavia Rezende, Ralf Gilsbach, Beatrice Pflueger-Mueller, Ilka Wittig, Ingrid Grummt, Teodora Ribarska, Ivan G. Costa, Harald Schwalbe, Ralf P. Brandes
Summary: Using bioinformatic techniques and biophysical studies, we identified a functionally important DNA:DNA:RNA triplex-forming lncRNA HIF1 alpha-AS1 in human endothelial cells, which reduces the expression of multiple genes by inducing triplex formation as an adapter. Additionally, we found that HIF1 alpha-AS1 is down-regulated in pulmonary hypertension and loss-of-function enhances gene de-repression and angiogenic capacity.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Xiaodong Ling, Junli Zuo, Meiqi Pan, Hongyan Nie, Jianzhong Shen, Qing Yang, Tien-Chieh Hung, Guangyu Li
Summary: The accumulation of nanoplastics exacerbates the toxic effects of microcystin on the liver of zebrafish, leading to cellular damage and oxidative stress. The presence of nanoplastics enhances the bioavailability of microcystin in the liver and alters the levels of reactive oxygen species, malondialdehyde, glutathione, and catalase, exacerbating the oxidative stress response.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Kang Ou-Yang, Tangqi Feng, Yifang Han, Guangyu Li, Jianhong Li, Hongju Ma
Summary: The study evaluated the enantioselective bioaccumulation, metabolism, and toxic effects of metolachlor and S-metolachlor in zebrafish, revealing different toxic effects of the two chemicals and potentially gender-specific impacts on the endocrine system. Most biological indicators returned to normal within 7 days after exposure, possibly due to rapid metabolism of the chemicals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Thermodynamics
Chaowei Wang, Chang'an Wang, Qinqin Feng, Qisen Mao, Xinyue Gao, Yongbo Du, Guangyu Li, Defu Che
Summary: The experimental study on oxy-fuel co-firing of pyrolyzed semi-coke powder and gasification residual carbon shows that it can reduce NOx generation and improve carbon burnout efficiency. This research provides guidance for the clean and efficient utilization of carbon-based solid wastes and the development of carbon capture technology.
Article
Engineering, Environmental
Renju Liu, Sufang Zhao, Benjuan Zhang, Guangyu Li, Xiaoteng Fu, Peisheng Yan, Zongze Shao
Summary: Plastic pollution poses a threat to marine ecosystems, with mangrove areas being heavily polluted. This study identified a diverse bacterial community capable of degrading polystyrene in a subtropical mangrove area. The genera Novosphingobium and Gordonia showed high degradation capability for polystyrene.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hanni Ke, Shuyan Tang, Ting Guo, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu, Jiucun Wang, Feng Zhang, Yingying Qin, Li Jin, Zi-Jiang Chen
Summary: Whole-exome sequencing in a cohort of 1,030 patients with POI identified new likely pathogenic variants and revealed different genetic architectures between primary and secondary amenorrhea. This study expands our understanding of the genetic landscape underlying POI and provides insights that have the potential to improve diagnostic genetic screenings.
Article
Environmental Sciences
Maoxin Zhang, Guangyu Li, Tingting He, Ge Zhai, Andong Guo, Hang Chen, Cifang Wu
Summary: The abandonment of cropland in China poses a threat to food security and has significant impacts on society, economy, and the natural environment. Mapping and monitoring abandoned cropland on a large scale has been a challenge. This study utilized high-resolution satellite data to detect and map abandoned cropland in China from 1990 to 2019, providing valuable insights into its spatial distribution, intensity, trends, frequency, and recultivation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Wenzhe Zhang, Shiru Xu, Rongrong Zhang, Zhuqing Li, Nianyu Li, Xiruo Zhang, Yueshuang Lu, Yuehong Bian, Ping Yang, Fang Fang, Yingying Qin, Xue Jiao
Summary: This study found that deficiency of IL-22 was associated with premature ovarian insufficiency (POI). The levels of IL-22 and IL-22BP were measured and compared among different groups, and it was discovered that IL-22 levels were significantly lower in the POI group. The study also identified a correlation between IL-22 and ovarian reserve markers, providing new insights into the autoimmune disturbance in POI and suggesting potential intervention strategies.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yu Qi, Yiyang Wang, Weilin Li, Shuning Zhuang, Shan Li, Keyan Xu, Qin Yingying, Ting Guo
Summary: Premature ovarian insufficiency (POI) is a diverse disease that affects the physical and mental health of millions of women worldwide. Genetic factors play an increasing role in the pathogenesis of POI, with several causative genes involved in meiosis. This study identified a novel homozygous variation in the SPO16 gene in one patient with POI, which disrupts mRNA splicing and leads to non-functional SPO16 protein. Together with previous findings on SHOC1 gene variations, this study highlights the essential roles of ZMM genes in maintaining ovarian function and expands the POI gene spectrum.
Article
Environmental Sciences
Senyang Wang, Liang Zheng, Mengyan Shen, Longsheng Zhang, Yiting Wu, Guangyu Li, Chuanbo Guo, Cunzhi Hu, Mingming Zhang, Yanming Sui, Xuexing Dong, Linlan Lv
Summary: The study found that microplastics eventually end up in sediment, posing a threat to benthic life. Three edible mollusks were exposed to polystyrene microplastics for 7 days and depurated for 3 days. After the exposure, microplastics were found in both the digestive and non-digestive systems of all three mollusks. Most of the microplastics were removed after the depuration period, with higher clearance rates in filter-feeding mollusks compared to surface deposit-feeding mollusks. The digestive enzymes of the deposit-feeding mollusk reacted significantly to the microplastic exposure, while oxidative responses were found in the filter-feeding mollusk. After depuration, the changes in digestive enzymes and oxidative states were fixed, but the neurotoxicity induced by microplastics was not recoverable.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Haoran Sun, Qiaoru Zhang, Chao Xu, Aipeng Mao, Hui Zhao, Miao Chen, Weili Sun, Guangyu Li, Tietao Zhang
Summary: This study aimed to explore the effect of diet energy on adult beagles and analyze the relation between diet and host and gut microbiota. It was found that feeding dogs low- or high-energy diets was harmful for glucostasis and promoted the relative abundance of pathogenic bacteria in the gut, while a medium-energy diet maintained an ideal body condition.
Article
Environmental Sciences
Qing Yang, Ping Deng, Dan Xing, Haoling Liu, Fang Shi, Lian Hu, Xi Zou, Hongyan Nie, Junli Zuo, Zimeng Zhuang, Meiqi Pan, Juan Chen, Guangyu Li
Summary: The fungicide difenoconazole was found to affect the development of the nervous system in zebrafish embryos, leading to inhibitory effects on heart rate and body length, increased malformation rate, and decreased locomotor activity. Difenoconazole treatment also significantly reduced dopamine and acetylcholine levels, while increasing acetylcholinesterase activity. Furthermore, the expression of genes involved in neurodevelopment was significantly altered.
Article
Obstetrics & Gynecology
Wenxin Song, Chenxi Li, Tong Wu, Zhongyuan Wang, Yujie Dang, Lingling Ding, Yingying Qin
Summary: AH has no impact on live birth but is associated with increased risks of pregnancy loss and preterm delivery (PTD).
HUMAN REPRODUCTION
(2023)
Article
Environmental Studies
Yaoben Lin, Yuanbo Wang, Xingjun Lv, Shuangyan Yue, Hongmei Liu, Guangyu Li, Jinghui Zhao
Summary: Fallowing is an effective method for self-recovery management of farmland, but it can cause a decline in grain production. Short-term fallow reduces food insecurity, but there are few studies on it. Our study focused on seven treatments and found that fallow management has a significant impact on soil properties. Fallowing can enhance soil microbial nitrogen transformation and has ecological benefits, especially with native vegetation.
Article
Pharmacology & Pharmacy
Chunxiao Liu, Mengdi Zhao, Jingyue Chen, Liwen Xu, Kaiying Wang, Guangyu Li
Summary: The compound Nodakenin (NK) has been found to attenuate bone loss caused by osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis. This is achieved through the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of Akt and NF kappa B signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Zoology
Peng -Xiang Duan, Zhi-Tao Wang, Tomonari Akamatsu, Nick Tregenza, Guang-Yu Li, Ke-Xiong Wang, Ding Wang
Summary: The biosonar activities of the Yangtze finless porpoise in the river-lake corridor are correlated with anthropogenic impacts and environmental variables. The corridor plays a key role in the conservation of the porpoise. During the COVID-19 lockdown, there was a significant increase in porpoise sonar detection. The detection of porpoise click trains and buzzes showed a significant negative correlation with boat traffic intensity. Light levels and hydrological conditions also significantly influenced porpoise biosonar activities.
ZOOLOGICAL RESEARCH
(2023)