DNA Aptamers against Vaccinia-Related Kinase (VRK) 1 Block Proliferation in MCF7 Breast Cancer Cells

DNA aptamers targeting Leishmania infantum H3 protein as potential diagnostic tools

(2020) Valerio Frezza et al.   ANALYTICA CHIMICA ACTA

RHOA and mDia1 promotes apoptosis of breast cancer cells via a high dose of doxorubicin treatment

(2020) Peter Bober et al.   Open Life Sciences

Clarithromycin effectively enhances doxorubicin-induced cytotoxicity and apoptosis in MCF7 cells through dysregulation of autophagy

(2020) Nahid Amani et al.   Advances in Medical Sciences

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

(2018) Ignacio Campillo-Marcos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

High expression of VRK1 is related to poor prognosis in glioma

(2018) Zhiyun Ben et al.   PATHOLOGY RESEARCH AND PRACTICE

Aptamers: novelty tools for cancer biology

(2018) Ricardo L. Pereira et al.   Oncotarget

Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

(2018) Aye M. Mon et al.   PLoS One

Aptamers as targeted therapeutics: current potential and challenges

(2017) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage

(2016) Diana M. Monsalve et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AS1411 Aptamer-Decorated Biodegradable Polyethylene Glycol–Poly(lactic-co-glycolic acid) Nanopolymersomes for the Targeted Delivery of Gemcitabine to Non–Small Cell Lung Cancer In Vitro

(2016) Mona Alibolandi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation

(2016) Takuyu Hashiguchi et al.   MOLECULAR ENDOCRINOLOGY

High VRK1 expression contributes to cell proliferation and survival in hepatocellular carcinoma

(2016) Wei Huang et al.   PATHOLOGY RESEARCH AND PRACTICE

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation

(2016) David S. Moura et al.   Scientific Reports

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage

(2015) Marcella Salzano et al.   Epigenetics

Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition

(2015) Namgyu Lee et al.   Oncotarget

AS1411-conjugated gold nanospheres and their potential for breast cancer therapy

(2015) Mohammad T. Malik et al.   Oncotarget

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

(2015) Marcella Salzano et al.   Oncotarget

VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage

(2014) Inmaculada López-Sánchez et al.   FEBS LETTERS

Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes

(2014) Tyler P. Molitor et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo

(2013) T P Molitor et al.   Oncogenesis

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage

(2012) Marta Sanz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks

(2010) Asako J. Nakamura et al.   CELL CYCLE

Mice Deficient in the Serine/Threonine Protein Kinase VRK1 Are Infertile Due to a Progressive Loss of Spermatogonia1

(2009) Matthew S. Wiebe et al.   BIOLOGY OF REPRODUCTION

Therapeutic Applications of DNA and RNA Aptamers

(2009) Kristina W. Thiel et al.   OLIGONUCLEOTIDES

Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis

(2008) P. Finetti et al.   CANCER RESEARCH

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets

(2008) Katherine J. Martin et al.   PLoS One