Review
Biology
Ramkumar Thirunavukarasu, C. George Priya Doss, R. Gnanasambandan, Mohanraj Gopikrishnan, Venketesh Palanisamy
Summary: Precision Medicine utilizes patients' genomic profiles and healthcare data to provide personalized medical outcomes. Deep learning models significantly influence precision medicine research due to their ability to handle large volumes of data and identify inherent features. This review emphasizes the importance of deep learning-based analytical models in handling big data in precision medicine research.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Yihao Liu, Minghua Wu
Summary: Deep learning has been successfully applied to various tasks in different fields, including disease diagnosis in medicine. By extracting multilevel features from medical data, deep learning helps doctors automatically assess diseases and monitor patients' physical health.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Farida Mohsen, Balqees Al-Saadi, Nima Abdi, Sulaiman Khan, Zubair Shah
Summary: Precision medicine has the potential to revolutionize cardiovascular diseases by tailoring treatment strategies to individual characteristics. Artificial intelligence (AI) is increasingly being applied in various areas of cardiovascular medicine, including diagnosis, prognosis, risk prediction, and treatment planning.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Critical Care Medicine
Jose Suarez
Summary: Big data and artificial intelligence are increasingly utilized in neurocritical care, aiding in data analysis, prediction, and decision-making in medical practice. Collaboration between multiple centers is crucial for the advancement and validation of AI technologies in healthcare to ensure fair and effective use in clinical settings.
NEUROCRITICAL CARE
(2022)
Review
Clinical Neurology
Yuzhe Liu, Yuan Luo, Andrew M. Naidech
Summary: Significant advances in medical data accumulation, computational techniques, and management have been made in the last decade. Big data and computational methods can address gaps in patient selection, complications prediction, and outcome understanding. Automated neuroimaging analysis can help triage patients, and data-intensive techniques enable accurate risk calculations for timely prediction of adverse events.
Review
Public, Environmental & Occupational Health
Pedro Elkind Velmovitsky, Tatiana Bevilacqua, Paulo Alencar, Donald Cowan, Plinio Pelegrini Morita
Summary: Precision medicine focuses on a large amount of data from a few individuals, whereas public health deals with limited data from a population. With the arrival of the Big Data era, the two fields are converging into precision public health, a study of biological and genetic factors supported by large amounts of population data.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Computer Science, Information Systems
Vittorio Palmieri, Andrea Montisci, Maria Teresa Vietri, Paolo C. Colombo, Silvia Sala, Ciro Maiello, Enrico Coscioni, Francesco Donatelli, Claudio Napoli
Summary: This study explores the opportunities and limitations of using artificial intelligence (AI) and big data in the field of heart transplantation. The results show that AI performs well in predicting prognosis and diagnosing heart transplantation, but there are risks of bias, lack of external validation, and limited applicability. Therefore, more unbiased research and high-quality data are needed to support the use of medical AI in clinical decision-making.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Koichiro Yasaka, Tomoya Tanishima, Yuta Ohtake, Taku Tajima, Hiroyuki Akai, Kuni Ohtomo, Osamu Abe, Shigeru Kiryu
Summary: This study investigated the use of deep learning reconstruction (DLR) to improve cervical spine MR images in the evaluation of degenerative changes. The results showed that DLR provided better image quality and performance compared to conventional reconstruction methods.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Lin Shui, Haoyu Ren, Xi Yang, Jian Li, Ziwei Chen, Cheng Yi, Hong Zhu, Pixian Shui
Summary: Radiogenomics utilizes medical imaging data and individual genetic information to construct prediction models for guiding treatment strategies and evaluating clinical outcomes. Despite some issues that need to be addressed, radiogenomics represents a repeatable and cost-effective approach for detection, offering a promising alternative for invasive interventions.
FRONTIERS IN ONCOLOGY
(2021)
Review
Clinical Neurology
Bharath Raju, Fareed Jumah, Omar Ashraf, Vinayak Narayan, Gaurav Gupta, Hai Sun, Patrick Hilden, Anil Nanda
Summary: The application and limitations of big data in the healthcare sector are influenced by factors such as lack of technical knowledge, technological limitations in data acquisition and analysis, and improper governance of healthcare big data. Despite these limitations, much of the medical literature is filled with articles related to big data, many of which are limited to neurosurgical registries, leading to misconceptions about big data.
JOURNAL OF NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Ljiljana Trtica Majnaric, Frantisek Babic, Shane O'Sullivan, Andreas Holzinger
Summary: Multimorbidity, the coexistence of two or more chronic diseases in a person, presents unique care needs that current healthcare systems struggle to address due to their focus on single diseases. To improve patient care in these cases, a radical change in medical research and treatment approaches is required, with a shift towards interactive research supported by artificial intelligence and big data analytics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Anuraj Nayarisseri, Ravina Khandelwal, Poonam Tanwar, Maddala Madhavi, Diksha Sharma, Garima Thakur, Alejandro Speck-Planche, Sanjeev Kumar Singh
Summary: Artificial Intelligence has revolutionized the drug development process by quickly identifying potential biologically active compounds. Machine Learning tools and algorithms, such as SVM and RF, are being used at various stages of drug designing and development to improve efficiency and accuracy. Successful cases have demonstrated the effectiveness of these models in identifying novel compounds and predicting activities for disease treatments.
CURRENT DRUG TARGETS
(2021)
Review
Oncology
Melissa Estevez, Corey M. Benedum, Chengsheng Jiang, Aaron B. Cohen, Sharang Phadke, Somnath Sarkar, Selen Bozkurt
Summary: This study presents an evaluation framework to assist model developers, data users, and other stakeholders in assessing the quality and applicability of data extracted using machine learning techniques from patient documents. This framework can facilitate effective utilization of this data in research.
Review
Biochemistry & Molecular Biology
Elettra Barberis, Shahzaib Khoso, Antonio Sica, Marco Falasca, Alessandra Gennari, Francesco Dondero, Antreas Afantitis, Marcello Manfredi
Summary: This review discusses the application of recent technological innovations in mass spectrometry to metabolomics analysis, with a focus on the use of artificial intelligence (AI) strategies. The article also explores the challenges and limitations of implementing metabolomics-AI systems, as well as recent tools and studies in disease classification and biomarker identification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Information Systems
Showkat Ahmad Bhat, Nen-Fu Huang
Summary: This article discusses the latest applications of Big Data in smart agriculture, including data creation methods, technology accessibility, device accessibility, software tools, data analytic methods, and appropriate applications of big data in precision agriculture. It also mentions some challenges faced in the widespread implementation of big data technology in agriculture.
Article
Geriatrics & Gerontology
Claudia Strafella, Valerio Caputo, Andrea Termine, Carlo Fabrizio, Giulia Calvino, Domenica Megalizzi, Paola Ruffo, Elisa Toppi, Nerisa Banaj, Andrea Bassi, Paola Bossu, Carlo Caltagirone, Gianfranco Spalletta, Emiliano Giardina, Raffaella Cascella
Summary: This study investigates the association of genetic variants in genes and miRNAs with aMCI and AD, and finds several variants associated with these conditions. These results provide insights into the neuroinflammatory and neurodegenerative mechanisms underlying aMCI and sporadic AD, and suggest potential for personalized treatments based on individual genetic makeup.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Valerio Caputo, Giulia Calvino, Claudia Strafella, Andrea Termine, Carlo Fabrizio, Giulia Trastulli, Arcangela Ingrasci, Cristina Peconi, Silvia Bardini, Angelo Rossini, Antonino Salvia, Giovanna Borsellino, Luca Battistini, Carlo Caltagirone, Raffaella Cascella, Emiliano Giardina
Summary: This study demonstrated the utility of a diagnostic kit for tracking the Omicron variant in Italy by testing COVID-19 samples. The results showed that the Omicron variant spread more rapidly compared to the Alpha and Delta variants. The use of this diagnostic kit could reduce the time and cost of monitoring strategies.
Article
Biochemistry & Molecular Biology
Andrea Termine, Carlo Fabrizio, Claudia Strafella, Valerio Caputo, Laura Petrosini, Carlo Caltagirone, Raffaella Cascella, Emiliano Giardina
Summary: This study used RNA-Seq data and various analysis methods to successfully identify subtypes of Parkinson's disease. Differential expression genes and disease mechanisms were discovered, providing important insights for precision medicine applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Riccardo Giannico, Luca Forlani, Valentina Andrioletti, Ettore Cotroneo, Andrea Termine, Carlo Fabrizio, Raffaella Cascella, Luca Salvaderi, Pasquale Linarello, Debora Varrone, Laura Gigante, Emiliano Giardina
Summary: In 1997, Cell-Free Fetal DNA (cffDNA) was found in maternal plasma. cffDNA has been studied as a source of non-invasive prenatal testing for fetal pathologies and paternity testing. This study presents a non-invasive prenatal paternity test (NIPAT) using Next Generation Sequencing (NGS) to analyze 861 Single Nucleotide Variants (SNV) from cffDNA. The test has shown high accuracy in real cases according to the log(CPI) values generated.
Article
Cell Biology
Valerio Caputo, Domenica Megalizzi, Carlo Fabrizio, Andrea Termine, Luca Colantoni, Cristina Bax, Juliette Gimenez, Mauro Monforte, Giorgio Tasca, Enzo Ricci, Carlo Caltagirone, Emiliano Giardina, Raffaella Cascella, Claudia Strafella
Summary: The study presents a protocol for methylation analysis combined with Machine Learning algorithms to classify patients with Facio-Scapulo-Humeral Dystrophy (FSHD). The results show significantly reduced methylation levels in FSHD patients compared to healthy controls. A Machine Learning model was developed to accurately classify FSHD patients, providing further evidence of DNA methylation as a powerful disease biomarker.
Article
Medicine, General & Internal
Andrea Cusumano, Benedetto Falsini, Fabian D'Apolito, Michele D'Ambrosio, Jacopo Sebastiani, Raffaella Cascella, Shila Barati, Emiliano Giardina
Summary: In this study, a longitudinal structure-function evaluation was performed on a patient with CDHR1-related retinal dystrophy over three years. The results showed that the patient experienced progressive visual loss accompanied by increased inner retinal thickness, while the outer retina remained unchanged. These findings suggest that inner retinal changes may be relevant for therapeutic interventions aiming to mitigate photoreceptor loss through gene therapy or stem cells.
Article
Health Care Sciences & Services
Carlo Fabrizio, Andrea Termine, Valerio Caputo, Domenica Megalizzi, Giulia Calvino, Giulia Trastulli, Arcangela Ingrasci, Simona Ferrante, Cristina Peconi, Angelo Rossini, Antonino Salvia, Carlo Caltagirone, Claudia Strafella, Emiliano Giardina, Raffaella Cascella
Summary: The severity of virus infection is related to genetic susceptibility, and there are differences in genetic distribution among different populations. Personalized risk assessment and treatment methods can improve the management of COVID-19 patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna, Andrea Termine, Carlo Fabrizio, Francesco Della Valle, Silvia Caioli, Luana Saba, Marco De Bardi, Francesca Balsamo, Anna Panuccio, Noemi Passarello, Anna Mattioni, Elisa Bisicchia, Cristina Zona, Valerio Orlando, Laura Petrosini
Summary: This study investigates fear-related disorders caused by inefficient fear extinction and identifies behavioral traits predicting adaptive or maladaptive fear extinction. It reveals that specific patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Through optogenetic manipulation of distinct neuronal populations, the study demonstrates the possibility to rescue or impair fear extinction.
Review
Nutrition & Dietetics
Valerio Caputo, Giovanni Tarantino, Silvano Junior Santini, Giovanna Fracassi, Clara Balsano
Summary: Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, is one of the most common liver diseases with increasing incidence worldwide. Its complex etiopathogenesis involves mitochondrial dysfunction, altered lipid metabolism, inflammation, and oxidative stress. Changes in diet and lifestyle, as well as the influence of natural compounds, can modulate these mechanisms and improve the understanding and treatment of MASLD.
Article
Psychology, Multidisciplinary
Daniela Laricchiuta, Andrea Termine, Carlo Fabrizio, Noemi Passarello, Francesca Greco, Fabrizio Piras, Eleonora Picerni, Debora Cutuli, Andrea Marini, Laura Mandolesi, Gianfranco Spalletta, Laura Petrosini
Summary: The analysis of language sequences and features reveals the ability and expression of emotional processing. The study analyzed the ability to identify and describe emotions through the Toronto Structured Interview, and used natural language processing and brain structure analysis to reveal the linguistic features and brain regions related to emotional expression.
BEHAVIORAL SCIENCES
(2022)