Article
Otorhinolaryngology
Jamie R. Oliver, Omar A. Karadaghy, Scott N. Fassas, Zack Arambula, Andres M. Bur
Summary: This study demonstrates that machine learning algorithms can accurately identify head and neck melanoma patients with very low risk of nodal metastasis, potentially reducing the need for sentinel lymph node biopsy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Alexander C. J. van Akkooi, Dirk Schadendorf, Alexander M. M. Eggermont
Summary: Sentinel lymph node biopsy (SLNB) was introduced in the 1990s to identify patients who may benefit from completion lymph node dissection. SLNB staging has been found to be the best for staging melanoma. Adjuvant systemic therapy and biomarkers are emerging, which might reduce the need for SLNB staging in the future.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Materials Science, Biomaterials
Ahmed A. Elbatrawy, Da Sol Lee, Sang Bong Lee, Hui-Jeon Jeon, Sijoon Lee, Kyung-ku Kang, Soo-Eun Sung, Ye Ri Han, Sung Jin Cho, Dong-Su Kim, Kil Soo Kim, Ghilsoo Nam, Yong Hyun Jeon
Summary: KSNP117, a novel quinoline-based fluorescent probe, shows great potential as a biocompatible and highly sensitive imaging agent for the accurate detection of sentinel lymph nodes, with no adverse effects on cell proliferation and excellent serum stability.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medicine, General & Internal
Roberto Cirocchi, Giulio Metaj, Michela Cicoletti, Fabrizio Arcangeli, Angelo De Sol, Giulia Poli, Paolo Bruzzone, Sara Gioia, Christos Anagnostou, Fabio Loreti, Simona Francesconi, Linda Ricci, Maria Elena Laurenti, Andrea Capotorti, Marco Artico, Vito D'Andrea, Brandon Michael Henry, Piergiorgio Fedeli, Luigi Carlini
Summary: Studies have shown significant heterogeneity in lymphatic drainage patterns of different cutaneous melanomas, emphasizing the need for multiple imaging evaluations in critical skin areas. The use of fluorescence lymphography with indocyanine green has greatly improved visualization at a microscopic level. It is crucial to combine SPET-CT scans with lymphoscintigraphy preoperatively and perform additional evaluations with indocyanine green intraoperatively to accurately identify sentinel nodes and reduce false negative rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Steven Morrison, Dale Han
Summary: Sentinel lymph node biopsy is crucial in the management of melanoma patients, providing important prognostic data and treatment options for various subtypes. Technological advances have improved the therapeutic potential of SLNB, while the management of patients with a positive SLN has evolved with new treatment options available.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Antonio Tejera-Vaquerizo, Aram Boada, Simone Ribero, Susana Puig, Sabela Paradela, David Moreno-Ramirez, Javier Canueto, Blanca de Unamuno-Bustos, Ana Brinca, Miguel A. Descalzo-Gallego, Simona Osella-Abate, Paola Cassoni, Sebastian Podlipnik, Cristina Carrera, Sergi Vidal-Sicart, Ramon Pigem, Agusti Toll, Ramon Rull, Llucia Alos, Celia Requena, Isidro Bolumar, Victor Traves, Angel Pla, Almudena Fernandez-Orland, Ane Jaka, Maria Teresa Fernandez-Figueras, Nina Anika Richarz, Ricardo Vieira, Rafael Botella-Estrada, Concepcion Roman-Curto, Lara Ferrandiz-Pulido, Nicolas Iglesias-Pena, Carlos Ferrandiz, Josep Malvehy, Pietro Quaglino, Eduardo Nagore
Summary: This study found that SLNB does not improve MSS, DFS, or OS in patients with thin melanoma. However, there is a significant difference in MSS, DFS, and OS between SLN-positive and -negative patients, confirming the value of SLNB as a prognostic procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Hanna Kakish, Trisha Lal, Jason E. Thuener, Jeremy S. Bordeaux, Ankit Mangla, Luke D. Rothermel, Richard S. Hoehn
Summary: This study evaluated the utility and prognostic value of sentinel lymph node biopsy (SLNB) in lentigo maligna melanoma (LMM) using large databases. The results showed that SLNB was associated with improved overall survival (OS) but not melanoma-specific survival (MSS) in LMM patients.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Ilyes Berania, Sharon Tzelnick, John R. de Almeida, Gregory McKinnon, David P. Goldstein
Summary: An international survey found that nearly half of head and neck surgeons would recommend completion lymph node dissection (CLND) for head and neck melanomas, which contrasts with current practice patterns for melanoma in other anatomical locations. Surgeons with access to immunotherapy treatment were less likely to recommend CLND. Further investigation is needed to understand the reasons for these practice variations.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Susan B. Kesmodel, Joshua P. Kronenfeld, Wei Zhao, Tulay Koru-Sengul, Neha Goel, Daniel N. Weingrad, Leonel Hernandez-Aya, Jose Lutzky, Lynn Feun, Mary Garland-Kledzik, Jessica S. Crystal
Summary: This study found no difference in overall survival between patients with head and neck melanoma who underwent sentinel lymph node biopsy (SLNB) only and those who underwent SLNB with completion lymph node dissection (CLND). Further research is needed to determine the role of CLND.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Tea Stuart Williams, Ben Tallon, Brandon Michael Adams
Summary: The controversy over whether completion lymph node dissection (CLND) should be performed following a positive sentinel lymph node biopsy (SLNB) remains. This study suggests that for a high-risk population with larger metastatic deposits in sentinel lymph nodes and higher rates of non-sentinel node involvement, forgoing CLND in the context of a positive SLNB may put patients at risk.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Oncology
Raghav Tripathi, Karen Larson, Graham Fowler, Dale Han, John T. Vetto, Jeremy S. Bordeaux, Wesley Y. Yu
Summary: This study developed and validated a personalized clinical decision-making tool (ELMO) using nationally representative data to predict lymphatic metastasis in melanoma patients. The tool showed high accuracy and sensitivity in predicting sentinel lymph node biopsy status and could reduce unnecessary procedures. It was externally validated at a large tertiary referral center.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Elena Parvez, Farzin Khosrow-Khavar, Teodora Dumitra, Carolyn Nessim, Ericka Bernard-Bedard, Justin Rivard, Vera Pravong, Sara Wang, Mai-Kim Gervais, Sarkis Meterissian, Sinziana Dumitra
Summary: This study examines real-world practices and outcomes of patients with melanoma sentinel lymph node metastases after the publication of the MSLT-II trial. The findings suggest that although practice patterns have changed, completion lymphadenectomy (CLND) does not reduce the risk of recurrence or mortality.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Che-Chia Hsu, Yi-Hua Liao, Yi-Shuan Sheen
Summary: A retrospective study in Taiwan found that sentinel lymph node biopsy (SLNB) offers survival benefits over nodal observation in early-stage melanoma patients. Among 227 patients who met the SLNB criteria, survival analysis showed significantly improved melanoma-specific survival in the SLNB group. Immediate completion lymph node dissection resulted in significantly longer melanoma-specific survival and distant-metastasis-free survival compared to nodal observation.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Dermatology
Adrienne B. Shannon, Cimarron E. Sharon, Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Kita Bogatch, Alexandra Thaler, Nicholas Kelly, John T. Vetto, Graham Fowler, Danielle DePalo, Vernon K. Sondak, John T. Miura, Mark B. Faries, Edmund K. Bartlett, Jonathan S. Zager, Giorgos C. Karakousis
Summary: Sentinel lymph node biopsy is not routinely recommended for T1a cutaneous melanoma due to low risk of positivity. This study identified age, primary tumor location, lymphovascular invasion, and mitotic rate as factors associated with positive sentinel lymph node in T1a melanoma patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Oncology
Michael J. Carr, Federico A. Monzon, Jonathan S. Zager
Summary: The necessity and application of sentinel lymph node biopsy in patients with primary tumors of different thicknesses remain controversial, with decisions left to patients and treating physicians. Recent studies have focused on predicting SLN positivity, providing valuable insights for improving physicians' predictive abilities.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Chemistry, Multidisciplinary
Thomas C. Gardinier, Ferdinand F. E. Kohle, James S. Peerless, Kai Ma, Melik Z. Turker, Joshua A. Hinckley, Yaroslava G. Yingling, Ulrich Wiesner
Article
Chemistry, Physical
Melik Z. Turker, Kai Ma, Ulrich Wiesner
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Chemistry, Physical
Melik Z. Turker, Thomas C. Gardinier, Joshua A. Hinckley, Cintia B. Contreras, Fem Woodruff, Kai Ma, Ferdinand F. E. Kohle, Ulrich B. Wiesner
CHEMISTRY OF MATERIALS
(2019)
Article
Oncology
Rupa Juthani, Brian Madajewski, Barney Yoo, Li Zhang, Pei-Ming Chen, Feng Chen, Melik Z. Turker, Kai Ma, Michael Overholtzer, Valerie A. Longo, Sean Carlin, Virginia Aragon-Sanabria, Jason Huse, Mithat Gonen, Pat Zanzonico, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron W. Brennan
CLINICAL CANCER RESEARCH
(2020)
Article
Chemistry, Physical
Thomas C. Gardinier, Melik Z. Turker, Joshua A. Hinckley, William P. Katt, Naedum DomNwachukwu, Fern Woodruff, Jessica Hersh, Jonathan Wang, Richard A. Cerione, Ulrich B. Wiesner
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Oncology
Aleksandra M. Urbanska, Raya Khanin, Simone Alidori, Sam Wong, Barbara P. Mello, Bryan Aristega Almeida, Feng Chen, Kai Ma, Melik Z. Turker, Tatyana Korontsvit, David A. Scheinberg, Pat B. Zanzonico, Ulrich Wiesner, Michelle S. Bradbury, Thomas P. Quinn, Michael R. McDevitt
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2020)
Article
Materials Science, Biomaterials
Ferdinand F. E. Kohle, Songying Li, Melik Z. Turker, Ulrich B. Wiesner
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Feng Chen, Brian Madajewski, Kai Ma, Daniella Karassawa Zanoni, Hilda Stambuk, Melik Z. Turker, Sebastien Monette, Li Zhang, Barney Yoo, Peiming Chen, Richard J. C. Meester, Sander de Jonge, Pablo Montero, Evan Phillips, Thomas P. Quinn, Mithat Gonen, Sonia Sequeira, Elisa de Stanchina, Pat Zanzonico, Ulrich Wiesner, Snehal G. Patel, Michelle S. Bradbury
Article
Engineering, Biomedical
Xiuli Zhang, Feng Chen, Melik Z. Turker, Kai Ma, Pat Zanzonico, Fabio Gallazzi, Manankumar A. Shah, Austin R. Prater, Ulrich Wiesner, Michelle S. Bradbury, Michael R. McDevitt, Thomas P. Quinn
Article
Oncology
Brian Madajewski, Feng Chen, Barney Yoo, Melik Z. Turker, Kai Ma, Li Zhang, Pei-Ming Chen, Rupa Juthani, Virginia Aragon-Sanabria, Mithat Gonen, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron Brennan
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Virginia Aragon-Sanabria, Anusha Aditya, Li Zhang, Feng Chen, Barney Yoo, Tianye Cao, Brian Madajewski, Rachel Lee, Melik Z. Turker, Kai Ma, Sebastien Monette, Peiming Chen, Jing Wu, Shutian Ruan, Michael Overholtzer, Pat Zanzonico, Charles M. Rudin, Cameron Brennan, Ulrich Wiesner, Michelle S. Bradbury
Summary: This study introduces an ultrasmall multimodal core-shell silica nanoparticle for the treatment of high-grade gliomas. The nanoparticle-drug conjugates showed significantly improved biological, therapeutic, and toxicological properties compared to the native drug. These findings suggest great translational potential for improving the therapeutic outcome of patients with high-grade gliomas.
CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jacob A. Erstling, Nirmalya Bag, Thomas C. Gardinier, Ferdinand F. E. Kohle, Naedum Domnwachukwu, Scott D. Butler, Teresa Kao, Kai Ma, Melik Z. Turker, Grant B. Feuer, Rachel Lee, Nada Naguib, James F. Tallman, Henry F. Malarkey, Lieihn Tsaur, William L. Moore, Dana V. Chapman, Tangi Aubert, Saurabh Mehta, Richard A. Cerione, Robert S. Weiss, Barbara A. Baird, Ulrich B. Wiesner
Summary: The study examines the interactions of fluorescent and poly(ethylene glycol)-coated (PEGylated) core-shell silica nanoparticles with biological barriers during oral delivery. It finds that ultra-small nanoparticles below 10 nm diameter passively pass through tight junctions, while particles above 20 nm diameter are actively transported through cells. Additionally, the in vivo experiments in mice demonstrate successful passage through the body and renal clearance without protein corona formation, suggesting the nanoparticles as viable candidates for oral administration.
ADVANCED MATERIALS
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Brian Madajewski, Feng Chen, Barney Yoo, Kai Ma, Melik Turker, Li Zhang, Pat Zanzonico, Ulrich Wiesner, Michelle Bradbury
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Feng Chen, Kai Ma, Brian Madajewski, Marcello Marelli, Melik Turker, Pat Zanzonico, Anand Subramony, Ulrich Wiesner, Michelle Bradbury
JOURNAL OF NUCLEAR MEDICINE
(2019)