Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Review
Chemistry, Inorganic & Nuclear
E. Pang, Shaojing Zhao, Benhua Wang, Guangle Niu, Xiangzhi Song, Minhuan Lan
Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Jun-Yong Shin, Seung-Hwan Kim, Sunhee Lee, Yong Sup Lee, Won-Sik Han, Kang-Kyun Wang
Summary: The study found that introducing electron-withdrawing fluorine atoms into the PC moiety can significantly enhance singlet oxygen generation and promote intersystem crossing. Cyclic voltammetry experiments revealed a linear relationship between quenching rate constants and oxidation potentials, indicating that the substituent effect is a key factor governing the efficiency of photosensitizers in generating singlet oxygen.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Engineering, Environmental
Ziyong Li, Si Chen, Yurou Huang, Hui Zhou, Shuren Yang, Haining Zhang, Mingxing Wang, Hui Guo, Jun Yin
Summary: Researchers have developed a novel photosensitizer system that allows for reversible control over singlet oxygen generation. This photosensitizer exhibits excellent aggregation-induced emission properties and photoswitching behavior, making it suitable for precise photodynamic therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Spectroscopy
Xiaorong Wang, Hui Lv, Yingkai Sun, Guoping Zu, Xiaozhen Zhang, Yufang Song, Fengyang Zhao, Jingang Wang
Summary: Research on porphyrin-based photosensitizer system is of great theoretical and practical significance in photodynamic therapy (PDT) for cancer treatment. In this article, a series of porphyrin derivatives were designed and synthesized, leading to the construction of a push-pull porphyrin photosensitizer with two symmetrical ethanethioate groups. Through characterization and theoretical analysis, the relationship between porphyrin structure and properties was revealed. The synthesized porphyrin compounds demonstrated high singlet oxygen generation and low dark toxicity under long-wavelength light.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Balaji Babu, Azole Sindelo, John Mack, Tebello Nyokong
Summary: The synthesis and characterization of two novel chlorin dyes, as well as their photodynamic properties on cancer cells and bacteria, were investigated. One of the dyes demonstrated better photocytotoxicity and bacterial inactivation, indicating its potential for future therapeutic applications.
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jing Ruan, Fang Li, Hao Tian, Jie Yu, Hongpei Deng, Shengfang Ge, Kam W. Leong
Summary: This study presents a carbon dot-based photosensitizer that generates cytotoxic singlet oxygen (O-1(2)) through multiple pathways, improving the therapeutic efficacy of photodynamic therapy (PDT) for uveal melanoma.
Review
Biochemistry & Molecular Biology
Akshay Kashyap, Elamparuthi Ramasamy, Vijayakumar Ramalingam, Mahesh Pattabiraman
Summary: This passage discusses the historical background, applications, and research progress of singlet oxygen generation through photosensitized excitation of molecular oxygen. It highlights the impact of molecular structure control through supramolecular photochemistry on this reaction.
Article
Chemistry, Applied
Jae Moon Lee, Seongsoo Kang, Tae Gyu Hwang, Hong Mo Kim, Woo Sung Lee, Dongho Kim, Jae Pil Kim
Summary: This study investigates the photophysical and solvatochromic properties of BODIPY-based D-A complexes, and verifies the hypothesis that decreasing ΔE-ST can increase SOQY. By designing experiments under more controlled conditions, more accurate data was obtained. Materials with CT character exhibited higher SOQY.
Review
Chemistry, Multidisciplinary
Muhammad Rizwan Younis, Gang He, Junle Qu, Jing Lin, Peng Huang, Xing-Hua Xia
Summary: Inorganic nanomaterials with intrinsic singlet oxygen generation capability are emerging as nano-photosensitizers for photodynamic therapy, exhibiting high quantum yield. Various materials such as metal-based, metal oxide-based, metal sulfide-based, carbon-based, phosphorus-based, and others have been utilized for material design to achieve phototherapeutic effects, with future research facing numerous challenges.
Article
Chemistry, Multidisciplinary
Feng Xu, Haoying Ge, Ning Xu, Cheng Yang, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Xinsheng Xu, Xiaojun Peng
Summary: In this study, a quartet photosensitizer Cy-DENT with high singlet oxygen quantum yield was reported, achieved through a radical enhanced inter-system crossing process. By introducing a TEMPO radical, over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN could be achieved under near infrared light irradiation. The electron-donating ability of the terminal substituent group can effectively control the production of singlet oxygen.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Keshavananda C. P. Prabhu, Manjunatha Nemakal, Muthumuni Managa, Tebello Nyokong, Lokesh Koodlur Sannegowda
Summary: The N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized and studied for photodynamic therapy. The aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine N4 molecules showed better activity against MCF-7 cells, suggesting their potential as an early biomarker of clinical response.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Biochemistry & Molecular Biology
Andra Dinache, Simona Nistorescu, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Petronela Prepelita, Angela Staicu
Summary: This study focuses on characterizing the spectral properties of TiO2 nanoparticles functionalized with three different porphyrin derivatives. UV-Vis absorption and FTIR-ATR spectroscopy were used to investigate the porphyrin-TiO2 complexes. The efficiency of singlet oxygen generation, an important factor in photodynamic therapy, was also evaluated. The results demonstrate that the porphyrin complexes with TiO2 exhibit higher singlet oxygen generation efficiency compared to bare porphyrins, making them potential candidates for in vitro photodynamic therapy assays.
Article
Nanoscience & Nanotechnology
Fei Yu, R. Paxton Thedford, Konrad R. Hedderick, Guillaume Freychet, Mikhail Zhernenkov, Lara A. Estroff, Katja C. Nowack, Sol M. Gruner, Ulrich B. Wiesner
Summary: Recent developments in quantum materials have shown promise in revolutionizing energy and information technologies. By utilizing block copolymers and niobia sol precursors, we successfully prepared mesoporous niobium carbonitride thin film superconductors through a scalable solution processing approach. This cost-effective and scalable method holds great potential for integration into existing microelectronics processing, combining the capabilities of soft matter self-assembly with quantum materials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Dana Chapman, Joshua A. Hinckley, Jacob A. Erstling, Lara A. Estroff, Ulrich B. Wiesner
Summary: Multicolor optical super-resolution microscopy (OSRM) techniques are well established in biological systems but have been slower to implement in materials science due to a lack of appropriate probes for orthogonal labeling of specific nanostructures in condensed states. These techniques are essential for visualizing nanodomain features of polymer nanocomposite bulk structures.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Physical
Robert T. Bell, Peter A. Beaucage, Marc J. Murphy, Aine B. Connolly, Ulrich Wiesner, David Ginley, R. Bruce Van Dover, Michael O. Thompson
Summary: The X-ray probed laser anneal mapping (XPLAM) is developed as a high throughput technique to produce temperature-dwell-transformation (TDT) diagrams of phases as a function of quench time and temperature. This method provides insight into the submillisecond kinetics of solid-solid phase transitions, and has been used to demonstrate the first annealing-driven synthesis of room temperature delta-Bi2O3. XPLAM is expected to be a powerful technique for rapid identification and exploration of synthetic routes to metastable phases.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Physical
William R. T. Tait, R. Paxton Thedford, Dana Chapman, Fei Yu, Judson W. Freidl, Ekaterina S. Sablina, Gavin M. Batsimm, Ulrich B. Wiesner
Summary: Two ultralarge pore-size carbons with 3D network architectures were synthesized, showing promise for future design as electrode materials in electrochemical energy storage devices.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Physical
Fei Wu, Thomas C. Gardinier, Melik Z. Turker, Feng Chen, Pei-Ming Chen, Aranapakam M. Venkatesan, Vaibhav Patel, Gregory P. Adams, Michelle S. Bradbury, Ulrich B. Wiesner, Geno Germano, Kai Ma
Summary: This study reports a chemical approach to covalently link chemotherapeutic drugs and targeting moieties to a poly(ethylene glycol) (PEG)-coated ultrasmall silica nanoparticle platform, achieving high drug loading capacity and favorable biodistribution and pharmacokinetics profiles.
CHEMISTRY OF MATERIALS
(2022)
Article
Oncology
Virginia Aragon-Sanabria, Anusha Aditya, Li Zhang, Feng Chen, Barney Yoo, Tianye Cao, Brian Madajewski, Rachel Lee, Melik Z. Turker, Kai Ma, Sebastien Monette, Peiming Chen, Jing Wu, Shutian Ruan, Michael Overholtzer, Pat Zanzonico, Charles M. Rudin, Cameron Brennan, Ulrich Wiesner, Michelle S. Bradbury
Summary: This study introduces an ultrasmall multimodal core-shell silica nanoparticle for the treatment of high-grade gliomas. The nanoparticle-drug conjugates showed significantly improved biological, therapeutic, and toxicological properties compared to the native drug. These findings suggest great translational potential for improving the therapeutic outcome of patients with high-grade gliomas.
CLINICAL CANCER RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
R. Paxton Thedford, Fei Yu, William R. T. Tait, Kunal Shastri, Francesco Monticone, Ulrich Wiesner
Summary: This review explores the opportunities and challenges of using soft matter science to synthesize quantum materials with advanced properties, highlighting existing work at the interface of these two fields and providing perspectives on future directions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Fei Wu, Pei-Ming Chen, Thomas C. Gardinier, Melik Z. Turker, Aranapakam M. Venkatesan, Vaibhav Patel, Tin Khor, Michelle S. Bradbury, Ulrich B. Wiesner, Gregory P. Adams, Geno Germano, Feng Chen, Kai Ma
Summary: An ultrasmall folate receptor alpha (FR alpha) targeted silica nanoparticle (C'Dot) drug conjugate (CDC) was developed to address the limitations of current systemic drug delivery for cancer management. The lead candidate formulation demonstrated specific targeting, multivalent binding properties, enzymatic responsive payload cleavage, stability in human plasma, rapid clearance, and minimal organ retention. It also showed superior efficacy in tumor penetration, cytotoxicity, and therapeutic outcome in various tumor models expressing different levels of FR alpha.
Article
Polymer Science
Sarah A. Hesse, Kevin E. Fritz, Peter A. Beaucage, Ethan M. Susca, Jin Suntivich, Ulrich Wiesner
Summary: This article presents a method for preparing asymmetric porous materials using copolymer and non-solvent induced phase separation (CNIPS) technique, and investigates the influence of thermal processing on the structure and properties of these materials. The results show that changing the processing conditions allows for control of the pore structure and composition of the materials, which affects the performance of the membranes. This study is significant for improving the application of porous materials in energy conversion and storage, separation, and catalysis.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Wennie Yun Lee, Dana Chapman, Fei Yu, William R. T. Tait, R. Paxton Thedford, Guillaume Freychet, Mikhail Zhernenkov, Lara A. Estroff, Ulrich B. Wiesner
Summary: Self-assembled block copolymer thin films and their nanocomposites have diverse applications due to their nanostructures. Optical super-resolution microscopy (OSRM) has emerged as an alternative method for characterizing nanoscopic polymer morphology. This study focuses on self-assembled triblock terpolymer thin films with all three blocks exposed at the top surface, and demonstrates the use of OSRM for multicolor characterization of chemically distinct nanodomains.
Article
Chemistry, Physical
Jacob A. Erstling, Nada Naguib, Joshua A. Hinckley, Rachel Lee, Grant B. Feuer, James F. Tallman, Lieihn Tsaur, Danni Tang, Ulrich B. Wiesner
Summary: Fluorescent labeling of cellular substructures using antibody-organic dye conjugates can be improved by conjugating widely available secondary antibodies and cationic species to ultrasmall different color dyes. These dyes show enhanced brightness and photostability compared to their parent dyes. By optimizing the conjugation and labeling protocols, three-color super-resolution microscopy imaging with improved resolution can be achieved.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jacob A. Erstling, Nirmalya Bag, Thomas C. Gardinier, Ferdinand F. E. Kohle, Naedum Domnwachukwu, Scott D. Butler, Teresa Kao, Kai Ma, Melik Z. Turker, Grant B. Feuer, Rachel Lee, Nada Naguib, James F. Tallman, Henry F. Malarkey, Lieihn Tsaur, William L. Moore, Dana V. Chapman, Tangi Aubert, Saurabh Mehta, Richard A. Cerione, Robert S. Weiss, Barbara A. Baird, Ulrich B. Wiesner
Summary: The study examines the interactions of fluorescent and poly(ethylene glycol)-coated (PEGylated) core-shell silica nanoparticles with biological barriers during oral delivery. It finds that ultra-small nanoparticles below 10 nm diameter passively pass through tight junctions, while particles above 20 nm diameter are actively transported through cells. Additionally, the in vivo experiments in mice demonstrate successful passage through the body and renal clearance without protein corona formation, suggesting the nanoparticles as viable candidates for oral administration.
ADVANCED MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Jorg G. Werner, Yuanzhi Li, Ulrich Wiesner
Summary: The multiscale architecture of electrochemical energy storage materials plays a critical role in device performance. The pore space of electrodes at nanoscale to macroscale determines mass transport and energy density. The size of charge-storing materials affects stability, capacitive charge storage, charge-transfer resistance, efficiency, and degradation. The use of block copolymer self-assembly provides nanoscale control and insights into the correlations observed in electrochemical energy storage.
Article
Energy & Fuels
Fumiaki Matsuoka, Kevin E. Fritz, Peter A. Beaucage, Fei Yu, Jin Suntivich, Ulrich Wiesner
Summary: The study shows that combining a high active-site density with favorable mass transport can be achieved by synthesizing gyroidal mesoporous Fe-N-C catalysts. Despite having mesoporous features, the catalyst exhibits competitive ORR activities.
JOURNAL OF PHYSICS-ENERGY
(2021)