Synaptic Vesicle Protein 2A Expression in Glutamatergic Terminals Is Associated with the Response to Levetiracetam Treatment

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

(2020) Pavel Klein et al.   EPILEPSIA

Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E

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Differential expression of SV2A in hippocampal glutamatergic and GABAergic terminals during postnatal development

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Analysis of Differential Expression of Synaptic Vesicle Protein 2A in the Adult Rat Brain

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Effect of levetiracetam on extracellular amino acid levels in the dorsal hippocampus of rats with temporal lobe epilepsy

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Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model

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Puzzling Out Synaptic Vesicle 2 Family Members Functions

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Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond

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Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy

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A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

(2016) Kentaro Tokudome et al.   Frontiers in Pharmacology

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission

(2016) Kentaro Tokudome et al.   Scientific Reports

Homozygous Mutation in Synaptic Vesicle Glycoprotein 2A Gene Results in Intractable Epilepsy, Involuntary Movements, Microcephaly, and Developmental and Growth Retardation

(2015) Fatema J. Serajee et al.   PEDIATRIC NEUROLOGY

Identification of the antiepileptic racetam binding site in the synaptic vesicle protein 2A by molecular dynamics and docking simulations

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Synaptic vesicle protein 2A: basic facts and role in synaptic function

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Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi

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Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis

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Determination of ng/mL Levetiracetam using Ultra-High-Performance Liquid Chromatography-Photodiode Absorbance

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Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice

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Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure

(2012) R. Hanaya et al.   NEUROSCIENCE

Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus

(2012) Yukihiro Ohno et al.   NEUROSCIENCE LETTERS

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

(2011) Anna L. Meehan et al.   JOURNAL OF NEUROPHYSIOLOGY

Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma

(2011) M. de Groot et al.   NEUROLOGY

Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A

(2011) Amy Nowack et al.   PLoS One

SV2 regulates neurotransmitter release via multiple mechanisms

(2010) Amy Nowack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Quantitative Comparison of Glutamatergic and GABAergic Synaptic Vesicles Unveils Selectivity for Few Proteins Including MAL2, a Novel Synaptic Vesicle Protein

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Cotrafficking of SV2 and Synaptotagmin at the Synapse

(2010) J. Yao et al.   JOURNAL OF NEUROSCIENCE

The pilocarpine model of epilepsy: what have we learned?

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Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling

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Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers

(2009) Sjoukje T. Toering et al.   EPILEPSIA

Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam

(2009) Rafal M. Kaminski et al.   EPILEPSIA

Down-regulation Synaptic Vesicle Protein 2A in the Anterior Temporal Neocortex of Patients with Intractable Epilepsy

(2009) Guibo Feng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes

(2008) Elena A. Matveeva et al.   EPILEPSIA

Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy

(2008) Erwin A. van Vliet et al.   EPILEPSIA

Review: Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited

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