Identification of the antiepileptic racetam binding site in the synaptic vesicle protein 2A by molecular dynamics and docking simulations

Exploring the Potential binding Sites of Some Known HDAC Inhibitors on Some HDAC8 Conformers by Docking Studies

(2014) Yudibeth Sixto-López et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Protein cocrystallization molecules originating from in vitro selected macrocyclic peptides

(2014) Christopher J Hipolito et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanisms of Levetiracetam in the Control of Status Epilepticus and Epilepsy

(2014) Laxmikant S. Deshpande et al.   Frontiers in Neurology

Mapping Myeloperoxidase to Identify its Promiscuity Properties Using Docking and Molecular Dynamics Simulations

(2013) LA Ramirez-Duran et al.   CURRENT PHARMACEUTICAL DESIGN

Synaptic vesicle protein 2A: basic facts and role in synaptic function

(2013) Julieta Griselda Mendoza-Torreblanca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A study of the structural properties and thermal stability of human Bcl-2 by molecular dynamics simulations

(2013) Ian Ilizaliturri-Flores et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding

(2012) Jiye Shi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Accurate de novo structure prediction of large transmembrane protein domains using fragment-assembly and correlated mutation analysis

(2012) T. Nugent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

(2011) Michel Gillard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

(2011) Anna L. Meehan et al.   JOURNAL OF NEUROPHYSIOLOGY

Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma

(2011) M. de Groot et al.   NEUROLOGY

SV2 regulates neurotransmitter release via multiple mechanisms

(2010) Amy Nowack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An Iris-Like Mechanism of Pore Dilation in the CorA Magnesium Transport System

(2010) Nilmadhab Chakrabarti et al.   BIOPHYSICAL JOURNAL

Levetiracetam: a comprehensive review

(2010) Amy Z Crepeau et al.   Expert Review of Neurotherapeutics

Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

(2010) Gilles J. P. Rautureau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cotrafficking of SV2 and Synaptotagmin at the Synapse

(2010) J. Yao et al.   JOURNAL OF NEUROSCIENCE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

SV2 Acts via Presynaptic Calcium to Regulate Neurotransmitter Release

(2010) Qun-Fang Wan et al.   NEURON

Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression

(2009) Anne Frycia et al.   ChemMedChem

Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers

(2009) Sjoukje T. Toering et al.   EPILEPSIA

Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy

(2009) Alain Matagne et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Down-regulation Synaptic Vesicle Protein 2A in the Anterior Temporal Neocortex of Patients with Intractable Epilepsy

(2009) Guibo Feng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis

(2009) W.-P. Chang et al.   JOURNAL OF NEUROSCIENCE

Visualization of SV2A conformations in situ by the use of Protein Tomography

(2008) Berkley A. Lynch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Review: Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited

(2008) Rainer Surges et al.   Therapeutic Advances in Neurological Disorders