A Glimpse of “Dicer Biology” Through the Structural and Functional Perspective

Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution

(2020) Xiaohui Tong et al.   International Journal of Endocrinology

In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster

(2020) Helen M Donelick et al.   RNA

Biochemical characterization of the dicing activity of Dicer-like 2 in the model filamentous fungus Neurospora crassa

(2020) Midori Tabara et al.   FUNGAL GENETICS AND BIOLOGY

Dissecting protein domain variability in the core RNA interference machinery of five insect orders

(2020) Fabricio Barbosa Monteiro Arraes et al.   RNA Biology

How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection

(2019) Paulette A. Greenidge et al.   Journal of Chemical Information and Modeling

Reaction Mechanisms of Pol IV, RDR2, and DCL3 Drive RNA Channeling in the siRNA-Directed DNA Methylation Pathway

(2019) Jasleen Singh et al.   MOLECULAR CELL

Study of the role of Mg2+ in dsRNA processing mechanism by bacterial RNase III through QM/MM simulations

(2019) Salvador I. Drusin et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

(2018) Zhongmin Liu et al.   CELL

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells

(2018) Annemarthe G van der Veen et al.   EMBO JOURNAL

Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference

(2017) Jan-Niklas Tants et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution of chaperone-mediated human RISC assembly

(2017) Ken Naruse et al.   RNA

A complex of Arabidopsis DRB proteins can impair dsRNA processing

(2017) Marie-Aude Tschopp et al.   RNA

Dicer uses distinct modules for recognizing dsRNA termini

(2017) Niladri K. Sinha et al.   SCIENCE

The Functional Cycle of Rnt1p: Five Consecutive Steps of Double-Stranded RNA Processing by a Eukaryotic RNase III

(2017) He Song et al.   STRUCTURE

Structure of Human DROSHA

(2016) S. Chul Kwon et al.   CELL

The Evolution of Antiviral Defense Systems

(2016) Benjamin R. tenOever   Cell Host & Microbe

De NovoRNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase

(2016) Yoshiko Maida et al.   MOLECULAR AND CELLULAR BIOLOGY

A specific dsRNA-binding protein complex selectively sequesters endogenous inverted-repeat siRNA precursors and inhibits their processing

(2016) Thomas Montavon et al.   NUCLEIC ACIDS RESEARCH

Chimeric DCL1-Partnering Proteins Provide Insights into the MicroRNA Pathway

(2016) Rodrigo S. Reis et al.   Frontiers in Plant Science

Drosophila Dicer-2 Cleavage Is Mediated by Helicase- and dsRNA Termini-Dependent States that Are Modulated by Loquacious-PD

(2015) Niladri K. Sinha et al.   MOLECULAR CELL

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis

(2015) Ross C. Wilson et al.   MOLECULAR CELL

Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex

(2015) Shintaro Iwasaki et al.   NATURE

The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities

(2015) Anna Kurzynska-Kokorniak et al.   NUCLEIC ACIDS RESEARCH

Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors

(2015) Sadeem Ahmad et al.   TRENDS IN BIOCHEMICAL SCIENCES

Plant virus replication and movement

(2015) Manfred Heinlein   VIROLOGY

A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans

(2014) Melanie Drake et al.   DEVELOPMENTAL CELL

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain

(2014) R. Fukunaga et al.   EMBO JOURNAL

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

Plant pattern-recognition receptors

(2014) Cyril Zipfel   TRENDS IN IMMUNOLOGY

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

Arabidopsis Double-Stranded RNA Binding Protein DRB3 Participates in Methylation-Mediated Defense against Geminiviruses

(2013) P. Raja et al.   JOURNAL OF VIROLOGY

The role of mutational robustness in RNA virus evolution

(2013) Adam S. Lauring et al.   NATURE REVIEWS MICROBIOLOGY

Substrate-specific structural rearrangements of human Dicer

(2013) David W Taylor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct substrate specificities of Arabidopsis DCL3 and DCL4

(2013) Hideaki Nagano et al.   NUCLEIC ACIDS RESEARCH

Multiple sensors ensure guide strand selection in human RNAi pathways

(2013) C. L. Noland et al.   RNA

Ribonuclease III mechanisms of double-stranded RNA cleavage

(2013) Allen W. Nicholson   Wiley Interdisciplinary Reviews-RNA

Second Double-Stranded RNA Binding Domain of Dicer-like Ribonuclease 1: Structural and Biochemical Characterization

(2012) Paula Burdisso et al.   BIOCHEMISTRY

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

(2012) Shuo Gu et al.   CELL

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Evolution of Animal and Plant Dicers: Early Parallel Duplications and Recurrent Adaptation of Antiviral RNA Binding in Plants

(2012) Krishanu Mukherjee et al.   MOLECULAR BIOLOGY AND EVOLUTION

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of human Dicer by the resident ER membrane protein CLIMP-63

(2012) Geneviève Pépin et al.   NUCLEIC ACIDS RESEARCH

Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion

(2012) S M Jafarnejad et al.   ONCOGENE

A comprehensive analysis of precursor microRNA cleavage by human Dicer

(2012) Y. Feng et al.   RNA

RNA-dependent RNA polymerases in RNA silencing

(2011) Yoshiko Maida et al.   BIOLOGICAL CHEMISTRY

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

The Inside-Out Mechanism of Dicers from Budding Yeasts

(2011) David E. Weinberg et al.   CELL

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer

(2011) Pierre Barraud et al.   EMBO JOURNAL

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

On the nature of in vivo requirements forrde-4in RNAi and developmental pathways inC. elegans

(2011) Daniel Blanchard et al.   RNA Biology

Specific requirement of DRB4, a dsRNA-binding protein, for the in vitro dsRNA-cleaving activity of Arabidopsis Dicer-like 4

(2011) A. Fukudome et al.   RNA

Compatibility with Killer Explains the Rise of RNAi-Deficient Fungi

(2011) I. A. Drinnenberg et al.   SCIENCE

Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing

(2010) Srinivas Chakravarthy et al.   JOURNAL OF MOLECULAR BIOLOGY

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells

(2010) Lasse Sinkkonen et al.   PLoS One

Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein

(2010) Seisuke Yamashita et al.   PROTEIN SCIENCE

Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila

(2010) K. Miyoshi et al.   RNA

Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction

(2010) H. Qin et al.   RNA

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

(2010) A. Nakagawa et al.   SCIENCE

Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

(2009) Kira S Makarova et al.   Biology Direct

Dicer is regulated by cellular stresses and interferons

(2009) Jennifer L. Wiesen et al.   MOLECULAR IMMUNOLOGY

Elimination of antiviral defense by viral RNase III

(2009) W. J. Cuellar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Dicer-TRBP Complex by Electron Microscopy

(2009) Pick-Wei Lau et al.   STRUCTURE

Heterodimer-based analysis of subunit and domain contributions to double-stranded RNA processing byEscherichia coliRNase IIIin vitro

(2008) Wenzhao Meng et al.   BIOCHEMICAL JOURNAL

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain

(2008) Vildan Dincbas-Renqvist et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanism of Induction and Suppression of Antiviral Immunity Directed by Virus-Derived Small RNAs in Drosophila

(2008) Roghiyh Aliyari et al.   Cell Host & Microbe

Autoinhibition of Human Dicer by Its Internal Helicase Domain

(2008) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

dsRNA Binding Properties of RDE-4 and TRBP Reflect Their Distinct Roles in RNAi

(2008) Greg S. Parker et al.   JOURNAL OF MOLECULAR BIOLOGY

DICER-LIKE2 Plays a Primary Role in Transitive Silencing of Transgenes in Arabidopsis

(2008) Sizolwenkosi Mlotshwa et al.   PLoS One

Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

(2008) Z. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting

(2008) D. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origins and evolution of eukaryotic RNA interference

(2008) S SHABALINA et al.   TRENDS IN ECOLOGY & EVOLUTION

HCV core protein interacts with Dicer to antagonize RNA silencing

(2008) Weixian Chen et al.   VIRUS RESEARCH