Review
Nutrition & Dietetics
Anna Kulawik, Judyta Cielecka-Piontek, Przemyslaw Zalewski
Summary: This article discusses the importance of lycopene in antioxidant and disease prevention, including cardiovascular diseases, diseases within the nervous system, diabetes, liver diseases, and ulcerative colitis. Research suggests that lycopene supplementation has significant promise for the treatment of illnesses marked by chronic inflammation and oxidative stress, but more human studies are needed to establish its effectiveness.
Review
Pharmacology & Pharmacy
Feng-Dan Zhu, Yu-Jiao Hu, Lu Yu, Xiao-Gang Zhou, Jian-Ming Wu, Yong Tang, Da-Lian Qin, Qing-Ze Fan, An-Guo Wu
Summary: Neuroinflammation is a common feature of neurodegenerative diseases, and inhibiting the over-activation of microglia is a promising approach for treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Min-Tae Jeon, Kyu-Sung Kim, Eun Seon Kim, Suji Lee, Jieun Kim, Hyang-Sook Hoe, Do-Geun Kim
Summary: The accumulation of blood factors in neurodegenerative diseases may activate the innate immune system in the central nervous system, suggesting that strengthening the integrity of the blood-brain barrier could help attenuate neurodegeneration.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Shani Berkowitz, Shany Guly Gofrit, Shay Anat Aharoni, Valery Golderman, Lamis Qassim, Zehavit Goldberg, Amir Dori, Nicola Maggio, Joab Chapman, Efrat Shavit-Stein
Summary: The study found that there is an interaction between neuroinflammation and coagulation, and enoxaparin can protect against inflammation induced by LPS, reducing neuronal damage. The findings may provide a new pharmacological mechanism for intervening in neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yan Wang, Limei Cui, He Zhao, Huhuifen He, Liang Chen, Xicheng Song, Dawei Liu, Jingjing Qiu, Yan Sun
Summary: Degenerative diseases have a significant impact on people's life and health, as well as on society. Microglia play a crucial role in neurodegenerative diseases, and inhibiting or activating their functions can effectively control and reduce the occurrence and progression of these diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Jean-Paul Motta, Simone Palese, Carmine Giorgio, Kevin Chapman, Alexandre Denadai-Souza, Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Seguy, Laurent Alric, Delphine Bonnet, Barbara Bournet, Louis Buscail, Cyrielle Gilletta, Andre G. Buret, John L. Wallace, Morley D. Hollenberg, Eric Oswald, Elisabetta Barocelli, Sylvie Le Grand, Bruno Le Grand, Celine Deraison, Nathalie Vergnolle
Summary: Elevated thrombin activity in the colon of Crohn's disease patients may lead to tissue damage and inflammation. Experimental evidence suggests that colonic thrombin and protease-activated receptor-1 could be potential mechanisms involved in mucosal damage and loss of function.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Biochemistry & Molecular Biology
Vichitra Chandrasekaran, Tousif Ahmed Hediyal, Nikhilesh Anand, Pavan Heggadadevanakote Kendaganna, Vasavi Rakesh Gorantla, Arehally M. Mahalakshmi, Ruchika Kaul Ghanekar, Jian Yang, Meena Kishore Sakharkar, Saravana Babu Chidambaram
Summary: Polyphenols, secondary metabolites from plants, possess therapeutic benefits and can regulate autophagy, inflammation, and neurodegeneration. They improve autophagy by clearing misfolded proteins, suppressing neuroinflammation and oxidative stress, and protecting against neurodegeneration. However, the exact interaction between polyphenols and autophagy markers is not fully understood and requires further research.
Review
Geriatrics & Gerontology
Bruno Santos-Lima, Enrica Caterina Pietronigro, Eleonora Terrabuio, Elena Zenaro, Gabriela Constantin
Summary: Neutrophil migration plays a crucial role in the development of neurological diseases with inflammatory components. These cells can damage the blood-brain barrier and the blood-cerebrospinal fluid barrier, leading to significant tissue damage.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Shakta Mani Satyam, Laxminarayana Kurady Bairy
Summary: Neuronutraceuticals play an important role in neuropathologies and have the potential to improve neuroinflammaging and cognitive performance. Further research is needed to understand the mechanisms and comprehensive impact of neuronutraceuticals, including randomized controlled trials and exploration of key issues.
Review
Pharmacology & Pharmacy
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li, Ranji Cui
Summary: Berberine, a natural alkaloid compound, has been studied for its effects on neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Current evidence shows that it can inhibit neuroinflammation, oxidative stress, and endoplasmic reticulum stress, reducing neuron damage and apoptosis. Further research is needed to fully understand the specific mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Long Xu, Sihang Yu, Jiaying Fu, Jian Wang, Xiaoyu Yan, Jing Su
Summary: Neurodegenerative diseases share the hallmark of neuroinflammation mediated by microglia and astrocytes. Excessive production of ROS leading to mtDNA release is proposed to be a key regulator of immune cells in neurological disorders. Understanding the relationship between mtDNA and pro-inflammatory microenvironment formation could advance therapeutic approaches to neurodegenerative diseases.
Review
Immunology
Behnaz Lahooti, Tanya Chhibber, Sounak Bagchi, Sree Pooja Varahachalam, Rahul D. Jayant
Summary: Neuroinflammation characterized by glial cell activation is a hallmark of several neurological and neurodegenerative disorders, with chronic inflammation being a critical contributing factor for disease manifestation in conditions like HIV-1-associated neurocognitive disorders, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Involvement of inflammasomes, particularly the NLRP complex, has been implicated in the development of these diseases, leading to the development of potential NLRP-targeting small-molecule therapeutics for the treatment of chronic neurological diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Melania Ruggiero, Rosa Calvello, Chiara Porro, Giovanni Messina, Antonia Cianciulli, Maria Antonietta Panaro
Summary: Coffee consumption with its bioactive compounds has shown to benefit human health and reduce the risk of neurodegenerative diseases. Neuroinflammation plays a critical role in the development of these diseases. Controlled caffeine delivery systems can help maintain high plasma caffeine levels for extended periods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Wolfgang Loescher, Pavel Klein
Summary: The prevailing standard in drug discovery has shifted from designing highly selective compounds to multi-target and combinatorial drug therapies. Although drug combination therapy is effective for symptomatic treatment, identifying clinically effective disease-modifying treatments for complex brain diseases remains challenging.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jiao Xiao, Yingjie Wang, Yanqiu Yang, Jingyu Liu, Gang Chen, Bin Lin, Yue Hou, Ning Li
Summary: Stephania epigaea, a folk medicine in southern China, has been found to contain alkaloids that can inhibit neuroinflammation. These alkaloids may have potential therapeutic effects for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
V. Rubovitch, A. Pharayra, M. Har-Even, O. Dvir, M. P. Mattson, C. G. Pick
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Ruth Defrin, Heba Beshara, Tali Benromano, Kutaiba Hssien, Chaim G. Pick, Miriam Kunz
Summary: The study tested the use of a new pain assessment tool, PAIC-15, in individuals with intellectual and developmental disabilities, and translated it into Arabic for dissemination among professionals. Results showed that PAIC-15 is a feasible and reliable tool to record pain behavior in IDD individuals.
Article
Multidisciplinary Sciences
Meirav Har-Even, Vardit Rubovitch, Whitney A. Ratliff, Bar Richmond-Hacham, Bruce A. Citron, Chaim G. Pick
Summary: The study suggests that a ketogenic diet may be neuroprotective in traumatic brain injury mouse models, leading to improved cognitive abilities, reduced neuronal degeneration, and attenuated astrocyte reactivity in specific brain regions. This indicates a potential new therapeutic strategy for treating TBI.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Doaa Qubty, Kati Frid, Meirav Har-Even, Vardit Rubovitch, Ruth Gabizon, Chaim G. Pick
Summary: Traumatic Brain Injury (TBI) is a common cause of neurological damage in young populations and is considered a risk factor for neurodegenerative diseases. A study has shown that Nano formulation of Pomegranate seed oil can prevent cognitive and behavioral decline caused by TBI, reduce neuronal death, gliosis, and mitochondrial damage, and increase levels of SIRT1 and SYP in the brain.
Article
Biochemistry & Molecular Biology
Dor Freidin, Meirav Har-Even, Vardit Rubovitch, Kathleen E. Murray, Nicola Maggio, Efrat Shavit-Stein, Lee Keidan, Bruce A. Citron, Chaim G. Pick
Summary: Traumatic brain injury (TBI) is the most common neurological disorder among people under 50, and when combined with organophosphate (OP) exposure, it can have fatal and long-term effects on the brain. This study used a mouse model to investigate the effects of mild TBI (mTBI) and/or paraoxon exposure on memory, neuron loss, and astrocytosis. The results showed that the combination of paraoxon exposure and mTBI had the greatest cognitive and behavioral deficits, indicating an additive effect of the insults. These findings provide further insight into the damaging effects of OP exposure in modern combat situations.
Article
Cell Biology
Shaul Schreiber, Chaim G. Pick
Summary: The findings suggest that the antipsychotic medications risperidone and amisulpride have strong antinociceptive effects mediated through involvement of the opioid system, with risperidone acting on mu, kappa, and delta opioid mechanisms while amisulpride selectively targets all three opioid receptor subtypes. Future clinical trials are needed to assess the potential use of these medications in pain management.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
