Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics

A computational model to design neural interfaces for lower-limb sensory neuroprostheses

(2020) Marek Zelechowski et al.   Journal of NeuroEngineering and Rehabilitation

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

(2020) Antonino A. La Mattina et al.   Advanced Science

A wireless millimetre-scale implantable neural stimulator with ultrasonically powered bidirectional communication

(2020) David K. Piech et al.   Nature Biomedical Engineering

Acute in vivo testing of a polymer cuff electrode with integrated microfluidic channels for stimulation, recording, and drug delivery on rat sciatic nerve

(2020) Sahar Elyahoodayan et al.   JOURNAL OF NEUROSCIENCE METHODS

Morphing electronics enable neuromodulation in growing tissue

(2020) Yuxin Liu et al.   NATURE BIOTECHNOLOGY

Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation

(2019) Yuxin Liu et al.   Nature Biomedical Engineering

Biomaterials: Foreign Bodies or Tuners for the Immune Response?

(2019) Erminia Mariani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Functionality of Transversal Intraneural Electrodes is Improved by Dexamethasone Treatment

(2019) N. de la Oliva et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording

(2019) Yingchao Zhang et al.   Science Advances

Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations

(2019) Shady Farah et al.   NATURE MATERIALS

Biomimetic sensory feedback through peripheral nerve stimulation improves dexterous use of a bionic hand

(2019) J. A. George et al.   Science Robotics

When Bio Meets Technology: Biohybrid Neural Interfaces

(2019) Amy E. Rochford et al.   ADVANCED MATERIALS

Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain

(2019) Francesco Maria Petrini et al.   NATURE MEDICINE

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

(2019) Wubin Bai et al.   Nature Biomedical Engineering

Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

(2019) Jongha Lee et al.   Nature Communications

Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

(2019) Cristiana R. Carvalho et al.   Frontiers in Bioengineering and Biotechnology

Characterization of multi-channel intraneural stimulation in transradial amputees

(2019) I. Strauss et al.   Scientific Reports

The foreign body response and morphometric changes associated with mesh-style peripheral nerve cuffs

(2018) Michael B. Christensen et al.   Acta Biomaterialia

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

(2018) Marco Capogrosso et al.   Journal of Neural Engineering

On the use of Parylene C polymer as substrate for peripheral nerve electrodes

(2018) Natàlia de la Oliva et al.   Scientific Reports

Nanofabricated Ultraflexible Electrode Arrays for High-Density Intracortical Recording

(2018) Xiaoling Wei et al.   Advanced Science

Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

(2018) Xi Xie et al.   Nature Biomedical Engineering

Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

(2018) Jiho Shin et al.   Nature Biomedical Engineering

A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers

(2018) Sandra Gribi et al.   Nature Communications

Thin Film Multi-Electrode Softening Cuffs for Selective Neuromodulation

(2018) María A. González-González et al.   Scientific Reports

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

(2017) Philip Grossen et al.   JOURNAL OF CONTROLLED RELEASE

Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

(2017) I Delgado-Martínez et al.   Journal of Neural Engineering

“Long-term stability of stimulating spiral nerve cuff electrodes on human peripheral nerves”

(2017) Breanne P. Christie et al.   Journal of NeuroEngineering and Rehabilitation

Restoration of motor control and proprioceptive and cutaneous sensation in humans with prior upper-limb amputation via multiple Utah Slanted Electrode Arrays (USEAs) implanted in residual peripheral arm nerves

(2017) Suzanne Wendelken et al.   Journal of NeuroEngineering and Rehabilitation

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

(2017) Joshua C. Doloff et al.   NATURE MATERIALS

Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain

(2017) Tao Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing gastrointestinal motility

(2017) Ghazaleh Haghiashtiani et al.   Nature Biomedical Engineering

Glial responses to implanted electrodes in the brain

(2017) Joseph W. Salatino et al.   Nature Biomedical Engineering

Macrophage reaction against biomaterials in the mouse model – Phenotypes, functions and markers

(2016) R. Klopfleisch   Acta Biomaterialia

Recent Advances in Flexible and Stretchable Bio-Electronic Devices Integrated with Nanomaterials

(2016) Suji Choi et al.   ADVANCED MATERIALS

A histological analysis of human median and ulnar nerves following implantation of Utah slanted electrode arrays

(2016) Michael B. Christensen et al.   BIOMATERIALS

Spatial and Functional Selectivity of Peripheral Nerve Signal Recording With the Transversal Intrafascicular Multichannel Electrode (TIME)

(2016) Jordi Badia et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

The pathology of the foreign body reaction against biomaterials

(2016) R. Klopfleisch et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Clinical applications of penetrating neural interfaces and Utah Electrode Array technologies

(2016) Richard A Normann et al.   Journal of Neural Engineering

Microchannel neural interface manufacture by stacking silicone and metal foil laminae

(2016) Henry T Lancashire et al.   Journal of Neural Engineering

Suppression of scarring in peripheral nerve implants by drug elution

(2016) James J FitzGerald   Journal of Neural Engineering

Restoring motor control and sensory feedback in people with upper extremity amputations using arrays of 96 microelectrodes implanted in the median and ulnar nerves

(2016) T S Davis et al.   Journal of Neural Engineering

Scanning electron microscopy of chronically implanted intracortical microelectrode arrays in non-human primates

(2016) James C Barrese et al.   Journal of Neural Engineering

Bioresorbable silicon electronic sensors for the brain

(2016) Seung-Kyun Kang et al.   NATURE

Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

(2016) Ki Jun Yu et al.   NATURE MATERIALS

Regenerative Electrode Interfaces for Neural Prostheses

(2016) Cort H. Thompson et al.   TISSUE ENGINEERING PART B-REVIEWS

Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses

(2016) Susan N. Christo et al.   Scientific Reports

Regenerated Sciatic Nerve Axons Stimulated through a Chronically Implanted Macro-Sieve Electrode

(2016) Matthew R. MacEwan et al.   Frontiers in Neuroscience

Materials and technologies for soft implantable neuroprostheses

(2016) Stéphanie P. Lacour et al.   Nature Reviews Materials

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

(2016) Eleonora Dondossola et al.   Nature Biomedical Engineering

Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases

(2015) Donghee Son et al.   ACS Nano

3D Printed Anatomical Nerve Regeneration Pathways

(2015) Blake N. Johnson et al.   ADVANCED FUNCTIONAL MATERIALS

Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees

(2015) Akhil Srinivasan et al.   BIOMATERIALS

Surgically implanted and non-invasive vagus nerve stimulation: a review of efficacy, safety and tolerability

(2015) E. Ben-Menachem et al.   EUROPEAN JOURNAL OF NEUROLOGY

A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals

(2015) Akhil Srinivasan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Functional recordings from awake, behaving rodents through a microchannel based regenerative neural interface

(2015) Russell K Gore et al.   Journal of Neural Engineering

A three-dimensional self-opening intraneural peripheral interface (SELINE)

(2015) A Cutrone et al.   Journal of Neural Engineering

Biomaterial based modulation of macrophage polarization: a review and suggested design principles

(2015) Rukmani Sridharan et al.   Materials Today

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

Electronic dura mater for long-term multimodal neural interfaces

(2015) I. R. Minev et al.   SCIENCE

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait

(2015) Katherine M. Musick et al.   Scientific Reports

The foreign body response to the Utah Slant Electrode Array in the cat sciatic nerve

(2014) M.B. Christensen et al.   Acta Biomaterialia

Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes

(2014) Takashi D.Y. Kozai et al.   BIOMATERIALS

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

(2014) Jessica K Nguyen et al.   Journal of Neural Engineering

NeuroGrid: recording action potentials from the surface of the brain

(2014) Dion Khodagholy et al.   NATURE NEUROSCIENCE

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Electrode-Tissue Interface: The Revolutionary Role of Steroid-Elution

(2014) HARRY G. MOND et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement

(2014) Hu Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neural interface provides long-term stable natural touch perception

(2014) D. W. Tan et al.   Science Translational Medicine

Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses

(2014) S. Raspopovic et al.   Science Translational Medicine

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

(2014) Ipek Yalcin et al.   Jove-Journal of Visualized Experiments

In vivotesting of a 3D bifurcating microchannel scaffold inducing separation of regenerating axon bundles in peripheral nerves

(2013) Irina I Stoyanova et al.   Journal of Neural Engineering

Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

(2013) Lei Zhang et al.   NATURE BIOTECHNOLOGY

A Microchannel Neuroprosthesis for Bladder Control After Spinal Cord Injury in Rat

(2013) D. J. Chew et al.   Science Translational Medicine

In vivo recordings of brain activity using organic transistors

(2013) Dion Khodagholy et al.   Nature Communications

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

(2012) Bryan N. Brown et al.   BIOMATERIALS

Regenerative Scaffold Electrodes for Peripheral Nerve Interfacing

(2012) Isaac P. Clements et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

A regenerative microchannel neural interface for recording from and stimulating peripheral axonsin vivo

(2012) James J FitzGerald et al.   Journal of Neural Engineering

Nerve Conduits for Nerve Repair or Reconstruction

(2012) D. N. Deal et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

A Physically Transient Form of Silicon Electronics

(2012) S.-W. Hwang et al.   SCIENCE

Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials

(2011) Sandra Franz et al.   BIOMATERIALS

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Biocompatibility of Chronically Implanted Transverse Intrafascicular Multichannel Electrode (TIME) in the Rat Sciatic Nerve

(2011) J. Badia et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles

(2011) Jordi Badia et al.   Journal of Neural Engineering

Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response

(2011) A. F. Malik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex

(2010) Brent D. Winslow et al.   BIOMATERIALS

In vitro evaluation of the long-term stability of polyimide as a material for neural implants

(2010) Birthe Rubehn et al.   BIOMATERIALS

A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve

(2010) Tim Boretius et al.   BIOSENSORS & BIOELECTRONICS

Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation

(2010) Hironobu Takahashi et al.   JOURNAL OF CONTROLLED RELEASE

On the identification of sensory information from mixed nerves by using single channel cuff electrodes

(2010) Stanisa Raspopovic et al.   Journal of NeuroEngineering and Rehabilitation

Polymers for neural implants

(2010) Christina Hassler et al.   JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS

Gene Expression Study of Monocytes/Macrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts

(2010) Lindsay Mesure et al.   PLoS One

Long Micro-Channel Electrode Arrays: A Novel Type of Regenerative Peripheral Nerve Interface

(2009) S.P. Lacour et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

On the mechanisms of biocompatibility

(2008) David F. Williams   BIOMATERIALS

Microchannels as Axonal Amplifiers

(2008) J.J. FitzGerald et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

In Vivo Penetration Mechanics and Mechanical Properties of Mouse Brain Tissue at Micrometer Scales

(2008) A.A. Sharp et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

On the Use of Longitudinal Intrafascicular Peripheral Interfaces for the Control of Cybernetic Hand Prostheses in Amputees

(2008) S. Micera et al.   IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

Mechanical ventilation or phrenic nerve stimulation for treatment of spinal cord injury-induced respiratory insufficiency

(2008) S Hirschfeld et al.   SPINAL CORD