TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility

mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation

(2020) Guihua Du et al.   DEVELOPMENT

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility

(2020) Margot J. Wyrwoll et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men

(2020) Csilla Krausz et al.   GENETICS IN MEDICINE

TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs

(2020) Daniel J. Foster et al.   CELL CYCLE

A systematic review and standardized clinical validity assessment of male infertility genes

(2019) Manon S Oud et al.   HUMAN REPRODUCTION

The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

(2019) Thomas Welte et al.   GENES & DEVELOPMENT

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

(2019) Qingsong Hu et al.   NATURE IMMUNOLOGY

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

(2019) Yajie Chen et al.   Cell Death & Disease

SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility

(2019) Samantha L.P. Schilit et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Disorders of spermatogenesis

(2018) Frank Tüttelmann et al.   Medizinische Genetik

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

(2018) Charuta Gavankar Furey et al.   NEURON

Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition

(2018) Pooja Kumari et al.   Nature Communications

Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination

(2018) Liang Zhao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Male infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects

(2018) Gulsah Koc et al.   INTERNATIONAL JOURNAL OF UROLOGY

The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids

(2018) Brian P. Hermann et al.   Cell Reports

LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition inCaenorhabditis elegans

(2017) Tatsuya Tsukamoto et al.   GENETICS

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Relevance of iPSC-derived human PGC-like cells at the surface of embryoid bodies to prechemotaxis migrating PGCs

(2017) Shino Mitsunaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway

(2017) Hongjiu Ren et al.   Oncotarget

LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition inCaenorhabditis elegans

(2017) Tatsuya Tsukamoto et al.   GENETICS

Key Signaling Events for Committing Mouse Pluripotent Stem Cells to the Germline Fate1

(2016) Jian-Qi Wang et al.   BIOLOGY OF REPRODUCTION

The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas

(2016) Daniel Nettersheim et al.   BRITISH JOURNAL OF CANCER

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate

(2016) Daniel Nettersheim et al.   Oncotarget

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile

(2015) F. Sugawa et al.   EMBO JOURNAL

X-Linked TEX11 Mutations, Meiotic Arrest, and Azoospermia in Infertile Men

(2015) Alexander N. Yatsenko et al.   NEW ENGLAND JOURNAL OF MEDICINE

A unique view on male infertility around the globe

(2015) Ashok Agarwal et al.   Reproductive Biology and Endocrinology

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71

(2015) Sibylle Mitschka et al.   Scientific Reports

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary

(2015) Y. Q. Shirleen Soh et al.   PLoS Genetics

The TRIM-NHL Protein LIN-41 and the OMA RNA-Binding Proteins Antagonistically Control the Prophase-to-Metaphase Transition and Growth of Caenorhabditis elegans Oocytes

(2014) Caroline A. Spike et al.   GENETICS

Stable Methylation at Promoters Distinguishes Epiblast Stem Cells from Embryonic Stem Cells and the In Vivo Epiblasts

(2014) Anne-Clémence Veillard et al.   STEM CELLS AND DEVELOPMENT

The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes

(2013) Kathleen A. Worringer et al.   Cell Stem Cell

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

(2013) Nils Grabole et al.   EMBO REPORTS

Distinct Expression Patterns Predict Differential Roles of the miRNA-Binding Proteins, Lin28 and Lin28b, in the Mouse Testis: Studies During Postnatal Development and in a Model of Hypogonadotropic Hypogonadism

(2013) Francisco Gaytan et al.   ENDOCRINOLOGY

LIN-41/TRIM71: emancipation of a miRNA target

(2013) M. Ecsedi et al.   GENES & DEVELOPMENT

SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes

(2013) Kathrin Gassei et al.   PLoS One

The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling

(2012) J. Chen et al.   GENES & DEVELOPMENT

The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing

(2012) Yu-Ling Chen et al.   JOURNAL OF PATHOLOGY

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

(2012) Inga Loedige et al.   NUCLEIC ACIDS RESEARCH

Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation

(2012) Hao-Ming Chang et al.   Nature Communications

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure

(2011) Betsy R. Maller Schulman et al.   CELL CYCLE

Copy Number Variants in Patients with Severe Oligozoospermia and Sertoli-Cell-Only Syndrome

(2011) Frank Tüttelmann et al.   PLoS One

Role of Genetics in Azoospermia

(2011) Joo Yeon Lee et al.   UROLOGY

Gonadal tumours and DSD

(2010) Leendert H.J. Looijenga et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Sex determination in mammalian germ cells: extrinsic versus intrinsic factors

(2010) Josephine Bowles et al.   REPRODUCTION

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse

(2009) Ke Zheng et al.   BMC DEVELOPMENTAL BIOLOGY

Klf4 reverts developmentally programmed restriction of ground state pluripotency

(2009) G. Guo et al.   DEVELOPMENT

Mouse germ cell development: From specification to sex determination

(2009) Katherine A. Ewen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A role for Lin28 in primordial germ-cell development and germ-cell malignancy

(2009) Jason A. West et al.   NATURE

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

(2009) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways

(2008) Hitomi Suzuki et al.   DEVELOPMENTAL BIOLOGY

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

(2008) K. Kurimoto et al.   GENES & DEVELOPMENT

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

(2008) Masashi Yamaji et al.   NATURE GENETICS