Review
Chemistry, Medicinal
Ronald Nicholas Laribee, Andrew B. Boucher, Saivikram Madireddy, Lawrence M. Pfeffer
Summary: This article explores the association between over-activation of autophagy and cell death in glioblastoma, as well as the inherent resistance of cancer stem cells to therapy. It suggests that autophagy promotes and maintains the stem-like state of cancer stem cells and contributes to their resistance to treatment.
Article
Medicine, Research & Experimental
Peng Peng, Hongtao Zhu, Dan Liu, Zirong Chen, Xiaolin Zhang, Zhongyin Guo, Minhai Dong, Lijun Wan, Po Zhang, Guohao Liu, Suojun Zhang, Fangyong Dong, Feng Hu, Fangling Cheng, Shijun Huang, Dongsheng Guo, Bin Zhang, Xingjiang Yu, Feng Wan
Summary: TGFBI, specifically expressed by tumor-associated macrophages (TAMs), plays a role in promoting glioma stem cells (GSCs) maintenance and tumor growth. The exact mechanism involves integrin alpha v beta 5-Src-Stat3 signaling pathway.
Article
Biochemistry & Molecular Biology
Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan
Summary: Linear ubiquitin has critical roles in cell signaling pathways, but its substrates are still rare. We developed a bio-orthogonal linear ubiquitin probe (NAEK-Ub) that enables covalent labeling and identification of linear ubiquitin-modified proteins in live cells. Using this strategy, we identified STAT3 as a substrate of linear ubiquitin and showed that linear ubiquitination negatively regulates STAT3 activity. Moreover, we demonstrated that the overexpression of the deubiquitinase OTULIN restricts linear ubiquitination on STAT3 in glioblastoma stem-like cells (GSCs), leading to persistent STAT3 signaling and maintenance of stemness and self-renewal of GSCs.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Pauliina Filppu, Jayendrakishore Tanjore Ramanathan, Kirsi J. Granberg, Erika Gucciardo, Hannu Haapasalo, Kaisa Lehti, Matti Nykter, Vadim Le Joncour, Pirjo Laakkonen
Summary: The CD109/STAT3 axis is crucial for maintaining the stemness and tumorigenicity of glioma stem cells (GSCs) and mediating chemoresistance. Targeting this axis could potentially overcome therapy resistance in glioblastoma.
Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Janina Remy, Benedikt Linder, Ulrike Weirauch, Bryan W. Day, Brett W. Stringer, Christel Herold-Mende, Achim Aigner, Knut Krohn, Donat Koegel
Summary: This study reveals an unknown role of STAT3 in sensitizing glioblastoma cells to excessive autophagy and supports the concept of utilizing autophagy and lysosomal membrane permeabilization for glioblastoma therapy.
Article
Oncology
Livia Elena Sima, Siqi Chen, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Cristina Ivan, Hao Huang, Bin Zhang, Daniela Matei
Summary: The study showed that host TG2 deficiency delayed tumor growth, increased infiltration of CD8(+) T cells, and decreased myeloid cell numbers in the peritoneal fluid. Loss of TG2 enhanced tumor antigen-specific CD8(+) T cell cytotoxic responses and reduced immune-suppressive signals in the tumor microenvironment, leading to decreased tumor burden.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Guangwen Wang, Wenshi Wang
Summary: GBM is a highly treatment-resistant tumor with a poor prognosis, and it has proven to be resistant to both traditional and newer immunotherapies. The need for innovative and efficient treatment strategies is urgent. This review provides a comprehensive overview of various cell therapies currently being used to treat GBM, discussing their efficacy, safety, mechanisms, and challenges, with the aim of identifying the next-generation immunotherapeutic approach to eliminate this dreadful disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhi Nie, Shan Cai, Zhimin Wei, Yanxi Li, Li Bian, Chenyang Wang, Xiangpeng Wang, Chunyan Wang
Summary: The study shows that SH3GL3 plays a critical role in GBM by inhibiting malignant behaviors of GBM cells and reducing the self-renewal ability of GSCs. High expression of SH3GL3 is associated with a favorable prognosis in GBM patients, indicating its potential as a therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Xun Yang, Zeyuan Liu, Xu Xu, Meng He, Hongtao Xiong, Lijun Liu
Summary: Casticin has shown inhibitory effects on the growth of glioblastoma cells by inducing apoptosis and autophagy. It also reduces the population of glioblastoma stem cells. The mechanisms involve the inhibition of Akt/mTOR and JAK2/STAT3 signaling pathways.
PHYTOTHERAPY RESEARCH
(2023)
Editorial Material
Hematology
Sebastian Kollmann, Veronika Sexl
Summary: This study reveals that STAT1 is a critical regulator of hematopoietic stem cell biology, specifically in a subset of HSCs characterized by elevated levels of MHCIIhi. This subset of HSCs possesses resistance against stress-induced myeloablation and is not expanded in calreticulin mutant mice.
Article
Multidisciplinary Sciences
Barbora Vitovcova, Veronika Skarkova, Radim Havelek, Jiri Soukup, Ananya Pande, Katerina Caltova, Emil Rudolf
Summary: In our study, we found that the repurposed drug flubendazole (FLU) significantly inhibits proliferation and survival of glioblastoma multiforme (GBM) cells. FLU affects microtubule structure and influences tubulins expression. Additionally, FLU decreases activation of STAT3 and leads to upregulation of p53 signaling pathway, resulting in cell cycle arrest and caspase-dependent cell death. These findings suggest FLU as a promising agent for GBM treatment.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
JongMyung Kim, Marine Potez, Chunhua She, Ping Huang, Qiulian Wu, Shideng Bao, Jeremy N. Rich, James K. C. Liu
Summary: Researchers have successfully isolated a 7-amino acid peptide, AWEFYFP, using in vitro and in vivo phage display biopanning methods. This peptide targets glioblastoma stem cells specifically and has the ability to penetrate the blood-brain barrier. It was found that Cadherin 2 is the receptor targeted by the peptide on glioblastoma cells.
Article
Biochemistry & Molecular Biology
Zhi Nie, Dating Cheng, Chenglong Pan, Zhimin Wei, Chenyang Wang, Chunyan Wang
Summary: The study revealed that SH3BGRL3 is highly expressed in GBM and glioma stem cells, and its high expression is associated with poor survival in GBM patients. SH3BGRL3 is directly regulated by STAT3, forming a positive feedback loop that enhances the tumorigenic potential of GBM.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Kun Liu, Jun Pu, Zhi Nie, Yulin Shi, Liping Jiang, Qisheng Wu, Yongbin Chen, Cuiping Yang
Summary: Research has shown that ivacaftor, commonly used for cystic fibrosis therapy, acts as a potent inhibitor of GSCs maintenance in glioblastoma, promoting cellular apoptosis, suppressing patient-derived xenograft tumor growth, and reducing stemness marker gene expressions of GSCs like CD133, CD44, and Sox2, ultimately inhibiting glioblastoma progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hai Song, Yanpei Wang, Chaojia Shi, Jianxiang Lu, Tian Yuan, Xiangpeng Wang
Summary: This study reveals that SH3KBP1 is highly expressed in GBM and associated with worse survival outcomes, potentially serving as a marker for GSCs. Silencing SH3KBP1 can significantly impair GBM cell proliferation, migration, and GSCs self-renewal, likely acting as an adaptor protein for EGFR signaling.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cong Zhang, Ning Li, Ying-ying Liu, Tian Yuan, Song Yang, Xiang-Peng Wang
Summary: The study reveals the important role of Cox15 in lung cancer and its potential as a prognostic marker for lung cancer patients in the future.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)