PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer

Immunotherapy and targeted therapy combinations in metastatic breast cancer

(2019) Francisco J Esteva et al.   LANCET ONCOLOGY

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

(2019) Xinyi Tu et al.   MOLECULAR CELL

Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway

(2018) Shaojia Wang et al.   ONCOGENE

Prognostic impact of programmed cell death ligand 1 (PD-L1) expression and its association with epithelial-mesenchymal transition in extrahepatic cholangiocarcinoma

(2018) Takashi Ueno et al.   Oncotarget

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion

(2018) Peixin Dong et al.   Frontiers in Oncology

Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells

(2017) Takumi Tomono et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

(2017) Jiejie Dong et al.   PLoS One

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

(2017) Shengwei Liu et al.   Oncotarget

PD-L1 and epithelial-mesenchymal transition in circulating tumor cells from non-small cell lung cancer patients: A molecular shield to evade immune system?

(2017) Cristina Raimondi et al.   OncoImmunology

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

(2015) J. Chen et al.   ANNALS OF ONCOLOGY

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

(2015) M. P. Mak et al.   CLINICAL CANCER RESEARCH

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

(2015) Abdullah Alsuliman et al.   Molecular Cancer

Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma

(2015) Patcharee Ritprajak et al.   ORAL ONCOLOGY

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Hanqiu Zheng et al.   CANCER CELL

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity

(2014) David Medgyesi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

LY2228820 Dimesylate, a Selective Inhibitor of p38 Mitogen-activated Protein Kinase, Reduces Angiogenic Endothelial Cord Formationin Vitroandin Vivo

(2013) Courtney M. Tate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

(2012) Alexandria M Haslehurst et al.   BMC CANCER

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin Carcinogenesis

(2011) Y. Cao et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

(2011) Xunhao Xiong et al.   MOLECULAR BIOLOGY OF THE CELL

B7-H1 Overexpression Regulates Epithelial–Mesenchymal Transition and Accelerates Carcinogenesis in Skin

(2010) Yujia Cao et al.   CANCER RESEARCH

PTP1B: a double agent in metabolism and oncogenesis

(2010) Shu-Chin Yip et al.   TRENDS IN BIOCHEMICAL SCIENCES

The two faces of PTP1B in cancer

(2009) Laurent Lessard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE