Breaking the therapeutic ceiling in drug development in ulcerative colitis

Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD - what, why, and how

(2021) Claudio Fiocchi et al.   Journal of Crohns & Colitis

Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD - disease outcome and response to therapy

(2021) Bram Verstockt et al.   Journal of Crohns & Colitis

First- and Second-line Pharmacotherapies for Patients with Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis

(2020) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Combination Biologic Therapy in Inflammatory Bowel Disease: Experience from a Tertiary Care Center

(2020) Lukasz Kwapisz et al.   Clinical Gastroenterology and Hepatology

Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients with Ulcerative Colitis

(2020) Kento Takenaka et al.   GASTROENTEROLOGY

Automatic, computer-aided determination of endoscopic and histological inflammation in patients with mild to moderate ulcerative colitis based on red density

(2020) Peter Bossuyt et al.   GUT

Big data in IBD: big progress for clinical practice

(2020) Nasim Sadat Seyed Tabib et al.   GUT

Efficacy and safety of simultaneous treatment with two biologic medications in refractory Crohn’s disease

(2020) Edward Yang et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Ileal and Rectal Ulcer Size Affects the Ability to Achieve Endoscopic Remission

(2020) Neeraj Narula et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Use of Combination Biologic or Small Molecule Therapy in Inflammatory Bowel Disease: A Retrospective Cohort Study

(2020) Kerri Glassner et al.   Journal of Digestive Diseases

Head-to-head trials in inflammatory bowel disease: past, present and future

(2020) Lieven Pouillon et al.   Nature Reviews Gastroenterology & Hepatology

What’s new in IBD therapy: an “omics network” approach

(2020) Claudio Fiocchi et al.   PHARMACOLOGICAL RESEARCH

Serum oncostatin M at baseline predicts mucosal healing in Crohn's disease patients treated with infliximab

(2020) Lorenzo Bertani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Letter: combination of biologics in inflammatory bowel diseases

(2020) Mathurin Fumery et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Dual Targeted Therapy: a possible option for the management of refractory Inflammatory Bowel Disease

(2020) Giuseppe Privitera et al.   Journal of Crohns & Colitis

ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology

(2020) Fernando Magro et al.   Journal of Crohns & Colitis

Computer aided diagnosis with monochromatic light endoscopy for scoring histological remission in ulcerative colitis.

(2020) Peter Bossuyt et al.   GASTROENTEROLOGY

Fully automated endoscopic disease activity assessment in ulcerative colitis

(2020) Heming Yao et al.   GASTROINTESTINAL ENDOSCOPY

Immune therapies in ulcerative colitis: are we beyond anti-TNF yet?

(2020) Tim Raine et al.   Lancet Gastroenterology & Hepatology

Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease

(2019) Bram Verstockt et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease

(2019) Bram Verstockt et al.   EBioMedicine

Evolving therapeutic goals in ulcerative colitis: towards disease clearance

(2019) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complete histologic normalisation is associated with reduced risk of relapse among patients with ulcerative colitis in complete endoscopic remission

(2019) Kelly C. Cushing et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Personalised medicine in Crohn's disease

(2019) Nurulamin M Noor et al.   Lancet Gastroenterology & Hepatology

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Systematic review with meta-analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis

(2018) C. Ma et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels

(2018) Fernando Magro et al.   GUT

Combining Anti-TNF-α and Vedolizumab in the Treatment of Inflammatory Bowel Disease: A Case Series

(2018) Lydia C T Buer et al.   INFLAMMATORY BOWEL DISEASES

Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort—An Epi-IBD Study

(2018) Johan Burisch et al.   Journal of Crohns & Colitis

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency

(2018) Olivier Collignon et al.   Trials

Practical characteristics of adaptive design in phase 2 and 3 clinical trials

(2017) A. Sato et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

(2017) Marcus Harbord et al.   Journal of Crohns & Colitis

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

(2017) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adaptive Randomization of Veliparib–Carboplatin Treatment in Breast Cancer

(2016) Hope S. Rugo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up

(2015) Robert V Bryant et al.   GUT

The Modified Mayo Endoscopic Score (MMES): A New Index for the Assessment of Extension and Severity of Endoscopic Activity in Ulcerative Colitis Patients

(2015) Triana Lobatón et al.   Journal of Crohns & Colitis

A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma

(2015) Christine Léauté-Labrèze et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic review with meta-analysis: the declining risk of colorectal cancer in ulcerative colitis

(2014) C. Castaño-Milla et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Role of Centralized Reading of Endoscopy in a Randomized Controlled Trial of Mesalamine for Ulcerative Colitis

(2013) Brian G. Feagan et al.   GASTROENTEROLOGY

Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis

(2013) William J. Sandborn et al.   GASTROENTEROLOGY

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events

(2013) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis

(2011) William J. Sandborn et al.   GASTROENTEROLOGY

Ulcerative Colitis as A Progressive Disease: The Forgotten Evidence

(2011) Joana Torres et al.   INFLAMMATORY BOWEL DISEASES