Practical characteristics of adaptive design in phase 2 and 3 clinical trials

Adaptive designs undertaken in clinical research: a review of registered clinical trials

(2016) Isabella Hatfield et al.   Trials

Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia

(2015) M. Dennis et al.   BLOOD

Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls

(2015) Peter Bauer et al.   STATISTICS IN MEDICINE

You May Have Worked on More Adaptive Designs Than You Think

(2015) Christopher S. Coffey   STROKE

An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review

(2015) Abigail Stevely et al.   PLoS One

Adaptive Clinical Trial Design

(2014) Shein-Chung Chow   Annual Review of Medicine

Experiences with an adaptive design for a dose-finding study in patients with osteoarthritis

(2014) Frank Miller et al.   Contemporary Clinical Trials

Dose-finding results in an adaptive, seamless, randomized trial of once-weekly dulaglutide combined with metformin in type 2 diabetes patients (AWARD-5)

(2014) Z. Skrivanek et al.   DIABETES OBESITY & METABOLISM

Adaptive clinical trial designs for European marketing authorization: a survey of scientific advice letters from the European Medicines Agency

(2014) Amelie Elsäßer et al.   Trials

Adaptive Design

(2014) Caroline Claire Morgan et al.   Therapeutic Innovation & Regulatory Science

Clinical experience with desvenlafaxine in treatment of pain associated with diabetic peripheral neuropathy

(2014) Rob Allen et al.   Journal of Pain Research

BMS-927711 for the acute treatment of migraine: A double-blind, randomized, placebo controlled, dose-ranging trial

(2013) Ronald Marcus et al.   CEPHALALGIA

An adaptive-design dose-ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery

(2013) A. T. Cohen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study

(2013) Krzysztof Selmaj et al.   LANCET NEUROLOGY

Stroke Treatment Academic Industry Roundtable

(2013) Jeffrey L. Saver et al.   STROKE

Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials

(2013) Ernest H Choy et al.   ARTHRITIS RESEARCH & THERAPY

Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial

(2012) René Westhovens et al.   ANNALS OF THE RHEUMATIC DISEASES

COX-2 inhibitors in prostate cancer treatment—hold your horses?

(2012) Ada S Cheung et al.   ASIAN JOURNAL OF ANDROLOGY

Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop

(2012) Christopher S Coffey et al.   Clinical Trials

Good Practices for Adaptive Clinical Trials in Pharmaceutical Product Development

(2012) Brenda Gaydos et al.   DRUG INFORMATION JOURNAL

Characteristics of Clinical Trials Registered in ClinicalTrials.gov, 2007-2010

(2012) Robert M. Califf   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adaptive trial designs: a review of barriers and opportunities

(2012) John A Kairalla et al.   Trials

Adaptive clinical trials in oncology

(2011) Donald A. Berry   Nature Reviews Clinical Oncology

Benefits, challenges and obstacles of adaptive clinical trial designs

(2011) Shein-Chung Chow et al.   Orphanet Journal of Rare Diseases

Barriers and opportunities for implementation of adaptive designs in pharmaceutical product development

(2010) Judith Quinlan et al.   Clinical Trials

Bayesian clinical trials at the University of Texas M. D. Anderson Cancer Center

(2009) Swati Biswas et al.   Clinical Trials

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

A Comparison of Methods for Adaptive Treatment Selection

(2008) Tim Friede et al.   BIOMETRICAL JOURNAL

Adaptive design methods in clinical trials – a review

(2008) Shein-Chung Chow et al.   Orphanet Journal of Rare Diseases

A group-sequential design for clinical trials with treatment selection

(2008) Nigel Stallard et al.   STATISTICS IN MEDICINE

Adaptive Dunnett tests for treatment selection

(2007) Franz Koenig et al.   STATISTICS IN MEDICINE