PLGA Nanoparticle-Based Formulations to Cross the Blood–Brain Barrier for Drug Delivery: From R&D to cGMP

Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease

(2020) Ruiling Xu et al.   International Journal of Nanomedicine

Gold nanorod–loaded (PLGA-PEG) nanocapsules as near-infrared controlled release model of anticancer therapeutics

(2020) Wael Mahmoud Ahmed Darwish et al.   LASERS IN MEDICAL SCIENCE

Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages

(2020) Yuqing Gong et al.   Scientific Reports

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study

(2020) Gina P. Hoyos-Ceballos et al.   Pharmaceutics

Odorranalectin modified PEG–PLGA/PEG–PBLG curcumin-loaded nanoparticle for intranasal administration

(2020) Xinrui Li et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19

(2020) Santosh Kumar et al.   Viruses-Basel

An Elvitegravir Nanoformulation Crosses the Blood–Brain Barrier and Suppresses HIV-1 Replication in Microglia

(2020) Yuqing Gong et al.   Viruses-Basel

Real Time Monitoring of Quality Attributes by In‐line Fourier Transform Infrared Spectroscopic Sensors at Ultrafiltration and Diafiltration of Bioprocess

(2020) Dhanuka P. Wasalathanthri et al.   BIOTECHNOLOGY AND BIOENGINEERING

A preformulation strategy for the selection of controlled-release components to simulate a subcutaneous implant

(2020) Kaining Zhi et al.   Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

Therapeutic Delivery to the Brain via the Lymphatic Vasculature

(2020) Pengfei Zhao et al.   NANO LETTERS

PLGA nanoparticles for nose to brain delivery of Clonazepam: formulation, optimization by 32 Factorial design, in vitro and in vivo evaluation

(2020) Pranav Shah et al.   Current Drug Delivery

Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and in vivo study of the effects of localized/targeted drug delivery on the treatment of triple-negative breast cancer

(2020) S. M. Jusu et al.   Scientific Reports

Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

(2020) Asit Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

(2020) Hossam Kadry et al.   Fluids and Barriers of the CNS

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Targeting Brain Disease in MPSII: Preclinical Evaluation of IDS-Loaded PLGA Nanoparticles

(2019) Laura Rigon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation

(2019) Kinam Park et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma

(2019) Chengkun Ye et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma

(2019) Xingzhen Zhang et al.   MEDICAL SCIENCE MONITOR

ABC Transporters at the Blood–Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

(2019) David Gomez-Zepeda et al.   Pharmaceutics

Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

(2018) Guoqiang Shao et al.   Contrast Media & Molecular Imaging

Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma

(2018) Hanmei Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

RVG29-modified docetaxel-loaded nanoparticles for brain-targeted glioma therapy

(2018) Hongchen Hua et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

(2018) M.J. Ramalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics

(2018) Dawei Ding et al.   Materials Science & Engineering C-Materials for Biological Applications

Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium

(2018) Andrea Falanga et al.   MOLECULES

Current Strategies for Brain Drug Delivery

(2018) Xiaowei Dong   Theranostics

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

(2018) Elena Sánchez-López et al.   JOURNAL OF NANOBIOTECHNOLOGY

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease

(2018) Shengnuo Fan et al.   DRUG DELIVERY

PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies

(2018) Marcelle Silva-Abreu et al.   International Journal of Nanomedicine

‘Dendrimer-Cationized-Albumin’ encrusted polymeric nanoparticle improves BBB penetration and anticancer activity of doxorubicin

(2018) Vimalkumar Johnson Muniswamy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue

(2018) Chenlu Lei et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection

(2018) Bapurao Surnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer

(2017) Jörgen Elgqvist   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclic hexapeptide-conjugated nanoparticles enhance curcumin delivery to glioma tumor cells and tissue

(2017) Xuemei Zhang et al.   International Journal of Nanomedicine

Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile

(2017) Pedram Rafiei et al.   International Journal of Nanomedicine

Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells

(2017) Yulia Malinovskaya et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas

(2017) Aniket S. Wadajkar et al.   JOURNAL OF CONTROLLED RELEASE

Farnesylthiosalicylic acid-loaded lipid-polyethylene glycol-polymer hybrid nanoparticles for treatment of glioblastoma

(2017) Abbas Kaffashi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model

(2017) Merdan Orunoğlu et al.   Materials Science & Engineering C-Materials for Biological Applications

Theranostic Nanomedicine; A Next Generation Platform for Cancer Diagnosis and Therapy

(2017) Rajeev Sharma et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3’-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression

(2017) Arijit Bhowmik et al.   Oncotarget

Tuning the Size of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles Fabricated by Nanoprecipitation

(2017) Wei Huang et al.   Biotechnology Journal

Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1–42-induced oxidative stress

(2017) Faiz Ul Amin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy

(2016) Yanna Cui et al.   ACS Applied Materials & Interfaces

Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS

(2016) Madhavan Nair et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

(2016) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System

(2016) Luc Bertrand et al.   CURRENT PHARMACEUTICAL DESIGN

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

(2016) Yu Xin et al.   International Journal of Nanomedicine

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

(2016) Chenchen Bi et al.   International Journal of Nanomedicine

Donepezil loaded PLGA-b-PEG nanoparticles: their ability to induce destabilization of amyloid fibrils and to cross blood brain barrier in vitro

(2016) Ipek Baysal et al.   JOURNAL OF NEURAL TRANSMISSION

Accelerating access to new medicines: Current status of facilitated regulatory pathways used by emerging regulatory authorities

(2016) Lawrence Liberti et al.   JOURNAL OF PUBLIC HEALTH POLICY

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

(2016) Lingyan Lv et al.   MOLECULAR PHARMACEUTICS

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations

(2015) Eric H. Decloedt et al.   CLINICAL PHARMACOKINETICS

Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles

(2015) Yung-Chih Kuo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier

(2015) C. Fornaguera et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles

(2015) Lei Wang et al.   JOURNAL OF DRUG TARGETING

Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis

(2014) Baoyan Wang et al.   BIOMATERIALS

iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas

(2014) Ting Kang et al.   BIOMATERIALS

Surface modified PLGA nanoparticles for brain targeting of Bacoside-A

(2014) S. Jose et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering

(2014) Piergiorgio Gentile et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PEG–PLGA copolymers: Their structure and structure-influenced drug delivery applications

(2014) Keru Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Theranostic Nanoparticles

(2014) F. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Evolution of Malignant Glioma Treatment

(2014) Richard Lee Price et al.   NEUROSURGERY

Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles

(2014) Adrian T. Press et al.   Nature Communications

Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy

(2013) Aneta J. Mieszawska et al.   BIOCONJUGATE CHEMISTRY

Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease

(2013) Chi Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Interaction of selegiline-loaded PLGA-b-PEG nanoparticles with beta-amyloid fibrils

(2013) Ipek Baysal et al.   JOURNAL OF NEURAL TRANSMISSION

The ABC of the Blood-Brain Barrier - Regulation of Drug Efflux Pumps

(2012) Anne Mahringer et al.   CURRENT PHARMACEUTICAL DESIGN

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system

(2012) Erica Locatelli et al.   JOURNAL OF NANOPARTICLE RESEARCH

Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease

(2012) Anila Mathew et al.   PLoS One

Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: In vitro and in vivo studies

(2011) U. Seju et al.   Acta Biomaterialia

Nanotechnological advances for the delivery of CNS therapeutics

(2011) Ho Lun Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymeric nanoparticles for drug delivery to the central nervous system

(2011) Toral Patel et al.   ADVANCED DRUG DELIVERY REVIEWS

Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy

(2011) You Ling et al.   BIOMATERIALS

Effects of surface modification of PLGA-PEG-PLGA nanoparticles on loperamide delivery efficiency across the blood–brain barrier

(2011) Yung-Chu Chen et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Crystallinity assessment and in vitro cytotoxicity of polylactide scaffolds for biomedical applications

(2011) J. R. Sarasua et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Self-Assembled Polymersomes Conjugated with Lactoferrin as Novel Drug Carrier for Brain Delivery

(2011) Yuan Yu et al.   PHARMACEUTICAL RESEARCH

Transferrin Adsorption onto PLGA Nanoparticles Governs Their Interaction with Biological Systems from Blood Circulation to Brain Cancer Cells

(2011) Jiang Chang et al.   PHARMACEUTICAL RESEARCH

Efficient Chemotherapy of Rat Glioblastoma Using Doxorubicin-Loaded PLGA Nanoparticles with Different Stabilizers

(2011) Stefanie Wohlfart et al.   PLoS One

Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

(2011) Hirenkumar K. Makadia et al.   Polymers

ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation

(2010) Andrew Z Wang et al.   Nanomedicine

In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems

(2010) Boitumelo Semete et al.   Nanomedicine-Nanotechnology Biology and Medicine

Alzheimer's disease drug development and the problem of the blood-brain barrier

(2009) William M. Pardridge   Alzheimers & Dementia

Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain

(2009) Zhao H. Wang et al.   BIOMATERIALS

Current advances in research and clinical applications of PLGA-based nanotechnology

(2009) Jian-Ming Lü et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

(2009) Ditte Marie Krohn Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Production of PLGA micro- and nanocomposites by supercritical fluid extraction of emulsions: I. Encapsulation of lysozyme

(2009) Johannes Kluge et al.   JOURNAL OF SUPERCRITICAL FLUIDS

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Preparation and characterization of interferon-loaded magnetic biodegradable microspheres

(2008) Shaobing Zhou et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS