TGF-β: Many Paths to CD103+ CD8 T Cell Residency

Developmental plasticity allows outside-in immune responses by resident memory T cells

(2020) Raissa Fonseca et al.   NATURE IMMUNOLOGY

Fatty acid oxidation controls CD8+ tissue-resident memory T cell survival in gastric adenocarcinoma

(2020) Run Lin et al.   Cancer Immunology Research

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

(2020) J. Justin Milner et al.   IMMUNITY

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

(2020) Cristina Ferreira et al.   NATURE IMMUNOLOGY

TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection

(2020) Emma C. Reilly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

(2020) Jingxia Wu et al.   Cell Reports

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

(2020) Henrique Borges da Silva et al.   IMMUNITY

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

(2020) Felix M. Behr et al.   NATURE IMMUNOLOGY

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

(2020) Toshiro Hirai et al.   IMMUNITY

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

(2019) Toshiro Hirai et al.   IMMUNITY

Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis

(2019) Yi Yang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

(2019) Monika Lodyga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Controlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β

(2019) Martijn Nolte et al.   TRENDS IN CELL BIOLOGY

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

(2018) Eric Tu et al.   IMMUNITY

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

(2018) Lalit K. Beura et al.   IMMUNITY

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory

(2018) Lalit K. Beura et al.   NATURE IMMUNOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

(2018) Simone L. Park et al.   NATURE IMMUNOLOGY

Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells

(2018) Felix M. Behr et al.   Frontiers in Immunology

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokine Receptor–Dependent Control of Skin Tissue–Resident Memory T Cell Formation

(2017) Ali Zaid et al.   JOURNAL OF IMMUNOLOGY

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(2017) J. Justin Milner et al.   NATURE

Transcriptional Regulation of Tissue-Resident Lymphocytes

(2017) Laura K. Mackay et al.   TRENDS IN IMMUNOLOGY

Induction of resident memory T cells enhances the efficacy of cancer vaccine

(2017) Mevyn Nizard et al.   Nature Communications

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation

(2016) Chaoyu Ma et al.   JOURNAL OF IMMUNOLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

(2016) Javed Mohammed et al.   NATURE IMMUNOLOGY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

TGF-β downregulates KLRG1 expression in mouse and human CD8+T cells

(2015) Sabrina Schwartzkopff et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

(2015) L M Wakim et al.   Mucosal Immunology

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

The emerging role of resident memory T cells in protective immunity and inflammatory disease

(2015) Chang Ook Park et al.   NATURE MEDICINE

Transforming growth factor-β signaling is constantly shaping memory T-cell population

(2015) Chaoyu Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8 + T Cells, Facilitating Protection from Local Cytomegalovirus Infection

(2015) Jenny Tosca Thom et al.   Cell Reports

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Smad and NFAT Pathways Cooperate To Induce CD103 Expression in Human CD8 T Lymphocytes

(2014) M. Mokrani et al.   JOURNAL OF IMMUNOLOGY

TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation

(2014) W. Cui et al.   JOURNAL OF IMMUNOLOGY

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection

(2013) Courtney R. Plumlee et al.   IMMUNITY

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues

(2013) J. B. Graham et al.   JOURNAL OF IMMUNOLOGY

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Molecular Pathways: Targeting the TGF-  Pathway for Cancer Therapy

(2012) A. L. Smith et al.   CLINICAL CANCER RESEARCH

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental and Antigen Receptor-Derived Signals Support Sustained Surveillance of the Lungs by Pathogen-Specific Cytotoxic T Lymphocytes

(2011) Y.-T. Lee et al.   JOURNAL OF VIROLOGY

Regional and mucosal memory T cells

(2011) Brian S Sheridan et al.   NATURE IMMUNOLOGY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4

(2010) Alexander J. Bankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

(2009) Shomyseh Sanjabi et al.   IMMUNITY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY