Detection of Rare Germline Variants in the Genomes of Patients with B-Cell Neoplasms

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial

(2020) Stuart J. Blakemore et al.   LEUKEMIA

Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing

(2020) Aayushi Srivastava et al.   Frontiers in Bioengineering and Biotechnology

CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system

(2020) Akiko Yamamoto et al.   PeerJ

DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse

(2019) Zi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula

(2019) Clare Bycroft et al.   Nature Communications

Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma

(2019) Julia González-Rincón et al.   PLoS One

The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution

(2019) Adrián Mosquera Orgueira et al.   BMC CANCER

Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer

(2019) Petra Kleiblova et al.   INTERNATIONAL JOURNAL OF CANCER

Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified

(2019) Maria Antonella Laginestra et al.   MODERN PATHOLOGY

Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells

(2019) Amany Almars et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compound Heterozygous DOCK8 Mutations in a Patient with B Lymphoblastic Leukemia and EBV-Associated Diffuse Large B Cell Lymphoma

(2019) David Buchbinder et al.   JOURNAL OF CLINICAL IMMUNOLOGY

ARID1A‐SIN3A drives retinoic acid‐induced neuroblastoma differentiation by transcriptional repression of TERT

(2019) Chi‐Bao Bui et al.   MOLECULAR CARCINOGENESIS

The whole genome landscape of Burkitt lymphoma subtypes

(2019) Razvan I. Panea et al.   BLOOD

MCL-1 inhibitors – where are we now (2019)?

(2019) Steven Fletcher   EXPERT OPINION ON THERAPEUTIC PATENTS

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

(2019) James Ropa et al.   HAEMATOLOGICA

Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

(2019) Stefanie N. Meyer et al.   IMMUNITY

ESCRT-III–dependent membrane repair blocks ferroptosis

(2019) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways

(2019) Geffen Kleinstern et al.   HUMAN MOLECULAR GENETICS

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

(2019) Julian Musa et al.   Nature Communications

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

(2018) Martina Mijuskovic et al.   BRITISH JOURNAL OF CANCER

Germline mutations in Protection of Telomeres 1 in two families with Hodgkin lymphoma

(2018) Mary L. McMaster et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pathogenic Germline Variants in 10,389 Adult Cancers

(2018) Kuan-lin Huang et al.   CELL

Biallelic TSC2 Mutations in a Patient With Chromophobe Renal Cell Carcinoma Showing Extraordinary Response to Temsirolimus

(2018) Pablo Maroto et al.   Journal of the National Comprehensive Cancer Network

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

(2018) Solip Park et al.   Nature Communications

Burden Testing of Rare Variants Identified through Exome Sequencing via Publicly Available Control Data

(2018) Michael H. Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

(2018) Ching-Hon Pui et al.   Nature Reviews Clinical Oncology

CADD: predicting the deleteriousness of variants throughout the human genome

(2018) Philipp Rentzsch et al.   NUCLEIC ACIDS RESEARCH

Genetic polymorphism at BCL2 as a predictor for rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone efficacy in patients with diffuse large B-cell lymphoma

(2017) Morteza Bashash et al.   HAEMATOLOGICA

Rare germline variants in known melanoma susceptibility genes in familial melanoma

(2017) Alisa M Goldstein et al.   HUMAN MOLECULAR GENETICS

Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma

(2017) Marta Bielska et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Rare germline variants in ATM are associated with chronic lymphocytic leukemia

(2017) G Tiao et al.   LEUKEMIA

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

(2017) Philip J. Law et al.   Nature Communications

Genetic polymorphism at BCL2 as a predictor for rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone efficacy in patients with diffuse large B-cell lymphoma

(2017) Morteza Bashash et al.   HAEMATOLOGICA

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo

(2016) J. A. Healy et al.   BLOOD

2016 US lymphoid malignancy statistics by World Health Organization subtypes

(2016) Lauren R. Teras et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Acute lymphoblastic leukemia in the context of RASopathies

(2016) Hélène Cavé et al.   European Journal of Medical Genetics

Acute lymphoblastic leukemia and lymphoma in the context of constitutional mismatch repair deficiency syndrome

(2016) Tim Ripperger et al.   European Journal of Medical Genetics

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Clinical response to everolimus in a patient with Hodgkin’s lymphoma harboring a TSC2 mutation

(2016) G F Perini et al.   Blood Cancer Journal

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy

(2015) Hervé Ghesquieres et al.   JOURNAL OF CLINICAL ONCOLOGY

Patterns ofCTCFandZFHX3Mutation and Associated Outcomes in Endometrial Cancer

(2015) Christopher J. Walker et al.   JNCI-Journal of the National Cancer Institute

Non-coding recurrent mutations in chronic lymphocytic leukaemia

(2015) Xose S. Puente et al.   NATURE

Mutations driving CLL and their evolution in progression and relapse

(2015) Dan A. Landau et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

(2015) Ana Ortega-Molina et al.   NATURE MEDICINE

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing

(2015) Claudia Vollbrecht et al.   PLoS One

Patterns and functional implications of rare germline variants across 12 cancer types

(2015) Charles Lu et al.   Nature Communications

Patterns ofCTCFandZFHX3Mutation and Associated Outcomes in Endometrial Cancer

(2015) Christopher J. Walker et al.   JNCI-Journal of the National Cancer Institute

Mutational spectrum of adult T-ALL

(2015) Martin Neumann et al.   Oncotarget

Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

(2014) Christine F. Skibola et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FLAGS, frequently mutated genes in public exomes

(2014) Casper Shyr et al.   BMC Medical Genomics

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

(2014) Anne Freitag et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications

(2014) Andy Rimmer et al.   NATURE GENETICS

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

(2014) Eliezer M Van Allen et al.   NATURE MEDICINE

Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer

(2014) Alice T. Shaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre-B-Cell Acute Lymphoblastic Leukemia in a Boy with Hereditary Multiple Exostoses Caused byEXT1Deletion

(2014) Takaya Nakane et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors

(2013) Adriana Aporta et al.   BIOCHEMICAL PHARMACOLOGY

Genetic Susceptibility to Chronic Lymphocytic Leukemia

(2013) Susan L. Slager et al.   SEMINARS IN HEMATOLOGY

Proinflammatory Homeobox Gene, ISX, Regulates Tumor Growth and Survival in Hepatocellular Carcinoma

(2012) S.-H. Hsu et al.   CANCER RESEARCH

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas

(2012) B. W. Baron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of glutathione transferases with 4-hydroxynonenal

(2011) Larissa M. Balogh et al.   DRUG METABOLISM REVIEWS

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS