Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression

Benzene and its effects on cell signaling pathways related to hematopoiesis and leukemia

(2020) Peter C.W. Lu et al.   JOURNAL OF APPLIED TOXICOLOGY

A systematic review and meta-analysis of haematological malignancies in residents living near petrochemical facilities

(2020) Calvin Jephcote et al.   Environmental Health

Benzene-associated immunosuppression and chronic inflammation in humans: a systematic review

(2020) Helen Guo et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Toxicity in hematopoietic stem cells from bone marrow and peripheral blood in mice after benzene exposure: Single-cell transcriptome sequencing analysis

(2020) Rongli Sun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers

(2019) Jingchao Ren et al.   PLoS One

Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

(2019) Mirjam Luijten et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The genetic and molecular pathogenesis of myelodysplastic syndromes

(2018) Rory M. Shallis et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture

(2018) Octavio Jiménez-Garza et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of gene expression predictors of occupational benzene exposure

(2018) Courtney Schiffman et al.   PLoS One

Biological monitoring of low level exposure to benzene in an oil refinery: Effect of modulating factors

(2018) Mariella Carrieri et al.   TOXICOLOGY LETTERS

Exposure to Benzene and Risk of Breast Cancer among Shoe Factory Workers in Italy

(2018) Adele Seniori Costantini et al.   TUMORI

Acetyl- l -carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in C3H/He mice

(2017) Rongli Sun et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Low personal exposure to benzene and 1,3-butadiene in the Swedish petroleum refinery industry

(2017) Pernilla Almerud et al.   INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

In vitro hydroquinone–induced instauration of histone bivalent mark on human retroelements (LINE-1) in HL60 cells

(2017) Monica Mancini et al.   TOXICOLOGY IN VITRO

Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects

(2016) Damiano Carbonari et al.   Biomarkers in Medicine

Diet-induced obesity increases the frequency ofPig-amutant erythrocytes in male C57BL/6J mice

(2016) Jeffrey K. Wickliffe et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Benzene exposure is associated with epigenetic changes (Review)

(2016) CONCETTINA FENGA et al.   Molecular Medicine Reports

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review

(2016) Grace Chappell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Exposure to BTEX and Ethers in Petrol Station Attendants and Proposal of Biological Exposure Equivalents for Urinary Benzene and MTBE

(2015) Laura Campo et al.   ANNALS OF OCCUPATIONAL HYGIENE

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia

(2015) A. Sanjuan-Pla et al.   BLOOD

Benzene exposure and risk of lymphohaematopoietic cancers in 25 000 offshore oil industry workers

(2015) J S Stenehjem et al.   BRITISH JOURNAL OF CANCER

Polycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study

(2015) Alexandra J. White et al.   CANCER CAUSES & CONTROL

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

(2015) Martyn T. Smith et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Benzene-Induced Aberrant miRNA Expression Profile in Hematopoietic Progenitor Cells in C57BL/6 Mice

(2015) Haiyan Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

Biology of Childhood Acute Lymphoblastic Leukemia

(2015) Deepa Bhojwani et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice

(2015) Nicola A. Philbrook et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells

(2015) Paik Wah Chow et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure

(2015) Rongli Sun et al.   International Journal of Environmental Research and Public Health

Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells

(2015) Mai Nanya et al.   PLoS One

DNA Hypermethylation of Cell Cycle (p15 and p16) and Apoptotic (p14, p53, DAPK and TMS1) Genes in Peripheral Blood of Leukemia Patients

(2014) Khaldon Bodoor et al.   Asian Pacific Journal of Cancer Prevention

Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors

(2014) M. A. Hahn et al.   CANCER RESEARCH

Aberrant miRNA profiles associated with chronic benzene poisoning

(2014) Wenlin Bai et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Long non-coding RNA NR_045623 and NR_028291 involved in benzene hematotoxicity in occupationally benzene-exposed workers

(2014) Wenlin Bai et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data

(2014) Jing Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

PTEN methylation involved in benzene-induced hematotoxicity

(2014) Jing Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement

(2014) M Bardini et al.   LEUKEMIA

Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene

(2014) Piero Lovreglio et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Changes in Poly(ADP-Ribosyl)ation Patterns in Workers Exposed to BTX

(2014) Yan Sha et al.   PLoS One

Thirteen years of air pollution hourly monitoring in a large city: Potential sources, trends, cycles and effects of car-free days

(2014) Mauro Masiol et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma

(2014) Jun Li et al.   Drug Design Development and Therapy

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

(2014) Eric L. Greer et al.   Cell Reports

Cytokine Network Involvement in Subjects Exposed to Benzene

(2014) Paola Lucia Minciullo et al.   Journal of Immunology Research

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

(2013) Christian Bronner et al.   BIOCHEMICAL PHARMACOLOGY

Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation

(2013) Z. Herceg et al.   CARCINOGENESIS

The use of biomonitoring data in exposure and human health risk assessment: benzene case study

(2013) Scott M. Arnold et al.   CRITICAL REVIEWS IN TOXICOLOGY

Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related-disease

(2013) Richard D. Irons et al.   GENES CHROMOSOMES & CANCER

Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers

(2013) Gunda Herberth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

(2013) David S. Hewings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

(2013) Guangtao Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Kazinol Q, a Natural Product from Formosan Plants, as an Inhibitor of DNA Methyltransferase

(2013) Jing-Ru Weng et al.   PHYTOTHERAPY RESEARCH

Interleukin-10 involvement in exposure to low dose of benzene

(2013) Giovanna Spatari et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Predicting the absorption of chemical vapours

(2012) Matias Rauma et al.   ADVANCED DRUG DELIVERY REVIEWS

Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene–Toluene–Xylene

(2012) Luis Cuauhtémoc Haro-García et al.   ARCHIVES OF MEDICAL RESEARCH

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Stem Cell and Benzene-Induced Malignancy and Hematotoxicity

(2012) Liping Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Absence of global hypomethylation in promoter hypermethylated Mixed Lineage Leukaemia-rearranged infant acute lymphoblastic leukaemia

(2012) Dominique J.P.M. Stumpel et al.   EUROPEAN JOURNAL OF CANCER

Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites

(2012) Lewis R. Vidler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

(2012) L Zhang et al.   LEUKEMIA

Latest advances and current challenges in the treatment of multiple myeloma

(2012) Anuj Mahindra et al.   Nature Reviews Clinical Oncology

Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells

(2012) N Chapman-Rothe et al.   ONCOGENE

Epigenetic Factors in Cancer Risk: Effect of Chemical Carcinogens on Global DNA Methylation Pattern in Human TK6 Cells

(2012) Ali M. Tabish et al.   PLoS One

Urinary Benzene Biomarkers and DNA Methylation in Bulgarian Petrochemical Workers: Study Findings and Comparison of Linear and Beta Regression Models

(2012) Wei Jie Seow et al.   PLoS One

Benzene absorption in animals and man: an overview

(2012) Jurij J. Hostynek et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene

(2011) Luoping Zhang et al.   CARCINOGENESIS

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

(2011) C. M. McHale et al.   CARCINOGENESIS

Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression

(2011) Ai Gao et al.   CELL BIOLOGY INTERNATIONAL

Benzene, the exposome and future investigations of leukemia etiology

(2011) Martyn T. Smith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytogenetic biomonitoring on a group of petroleum refinery workers

(2011) Emiliano Basso et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Effects of benzene and its metabolites on global DNA methylation in human normal hepatic l02 cells

(2011) Junjie Hu et al.   ENVIRONMENTAL TOXICOLOGY

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

(2011) Sebastian Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzene Induces Cytotoxicity without Metabolic Activation

(2011) Takuro Nishikawa et al.   JOURNAL OF OCCUPATIONAL HEALTH

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Advances in Understanding Benzene Health Effects and Susceptibility

(2010) Martyn T. Smith   Annual Review of Public Health

Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures

(2010) M.G. Bird et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

(2010) M.E. (Bette) Meek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning

(2010) Caihong Xing et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A review of the potential association between childhood leukemia and benzene

(2010) David Pyatt et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fluorescence In Situ Hybridization in the Definitive Diagnosis of Malignant Mesothelioma in Effusion Cytology

(2010) Spasenija Savic et al.   CHEST

Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis

(2010) Abdul Khalade et al.   Environmental Health

Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels

(2010) Cliona M. McHale et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epigenetic therapy in myelodysplastic syndromes

(2010) Caterina Musolino et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Micronucleus-centromere assay in workers occupationally exposed to low level of benzene

(2010) Yang Jee Kim et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide

(2010) Z Ji et al.   LEUKEMIA

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Cancer incidence in a petrochemical industry area in Sweden

(2010) Gösta Axelsson et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Induction of apoptosis in human leukemia cells through the production of reactive oxygen species and activation of HMOX1 and Noxa by benzene, toluene, and o-xylene

(2010) Sailendra Nath Sarma et al.   TOXICOLOGY

In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species

(2010) Helen J. Badham et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression

(2010) Ai Gao et al.   TOXICOLOGY LETTERS

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Gap junction intercellular communication and benzene toxicity

(2009) Edgar Rivedal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A hospital-based case-control study of acute myeloid leukemia in Shanghai: Analysis of environmental and occupational risk factors by subtypes of the WHO classification

(2009) Otto Wong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Benzene as a cause of lymphoproliferative disorders

(2009) Bernard D. Goldstein   CHEMICO-BIOLOGICAL INTERACTIONS

Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms

(2009) Cliona M. McHale et al.   GENOMICS

Aging and human CD4+ regulatory T cells

(2009) Kyung-A. Hwang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Paradigmenwechsel in der Beurteilung myeloischer und lymphatischer Neoplasien bei beruflicher Benzolexposition (BK-Ziffer 1303)

(2009) Stefanie Beelte et al.   MEDIZINISCHE KLINIK

Benzene Metabolite Hydroquinone Up-Regulates Chondromodulin-I and Inhibits Tube Formation in Human Bone Marrow Endothelial Cells

(2009) H. Zhou et al.   MOLECULAR PHARMACOLOGY

In utero and acute exposure to benzene: Investigation of DNA double-strand breaks and DNA recombination in mice

(2009) Annette Lau et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Acute childhood leukaemia and residence next to petrol stations and automotive repair garages: the ESCALE study (SFCE)

(2009) P Brosselin et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Low air levels of benzene: Correlation between biomarkers of exposure and genotoxic effects

(2009) Maria Enrica Fracasso et al.   TOXICOLOGY LETTERS

Correlation between environmental and biological monitoring of exposure to benzene in petrochemical industry operators

(2009) Mariella Carrieri et al.   TOXICOLOGY LETTERS

Epigenetic Changes in Cancer

(2008) Christine A. Iacobuzio-Donahue   Annual Review of Pathology-Mechanisms of Disease

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

Temporal Variation in the Association between Benzene and Leukemia Mortality

(2008) David B. Richardson   ENVIRONMENTAL HEALTH PERSPECTIVES

Childhood Lymphohematopoietic Cancer Incidence and Hazardous Air Pollutants in Southeast Texas, 1995–2004

(2008) Kristina W. Whitworth et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Specificity of the Chromodomain Y Chromosome Family of Chromodomains for Lysine-methylated ARK(S/T) Motifs

(2008) Wolfgang Fischle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of the NQO1, MPO, and XRCC1 Polymorphisms and Chromosome Damage Among Workers at a Petroleum Refinery

(2008) Yang Jee Kim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Meta-analysis of benzene exposure and non-Hodgkin lymphoma: biases could mask an important association

(2008) C Steinmaus et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE