Combinatorial screen of dynamic mechanical stimuli for predictive control of MSC mechano-responsiveness

A multilayered valve leaflet promotes cell-laden collagen type I production and aortic valve hemodynamics

(2020) Aline L.Y. Nachlas et al.   BIOMATERIALS

Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells

(2020) Ronald G. Ireland et al.   BIOMATERIALS

High Throughput Screening of Cell Mechanical Response Using a Stretchable 3D Cellular Microarray Platform

(2020) Kabilan Sakthivel et al.   Small

H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification

(2019) Dario Nicetto et al.   SCIENCE

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

(2019) Gabriel M. Pagnotti et al.   Nature Reviews Endocrinology

Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues

(2018) Haijiao Liu et al.   BIOMATERIALS

High-throughput approaches for screening and analysis of cell behaviors

(2018) Jungmok Seo et al.   BIOMATERIALS

The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix

(2018) Franco Klingberg et al.   JOURNAL OF CELL SCIENCE

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

(2018) Mariëlle Walraven et al.   MATRIX BIOLOGY

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

(2018) Sebastián L. Vega et al.   Nature Communications

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells

(2018) Anouk R. Killaars et al.   Advanced Science

A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells

(2016) Haijiao Liu et al.   Acta Biomaterialia

Mechanical stimulation in the engineering of heart muscle

(2016) Norman Yu Liaw et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Heart valve regeneration: the need for systems approaches

(2016) Jenna Usprech et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow

(2014) Joseph Gardinier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Two-factor designs

(2014) Martin Krzywinski et al.   NATURE METHODS

Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays

(2013) Eric H. Nguyen et al.   BIOMATERIALS

Combating Adaptation to Cyclic Stretching by Prolonging Activation of Extracellular Signal-Regulated Kinase

(2013) Justin S. Weinbaum et al.   Cellular and Molecular Bioengineering

Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells

(2013) Christopher Moraes et al.   Integrative Biology

Mesenchymal stem cell mechanobiology and emerging experimental platforms

(2013) L. MacQueen et al.   Journal of the Royal Society Interface

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials

(2012) Luke MacQueen et al.   LAB ON A CHIP

Direct Detection of Cellular Adaptation to Local Cyclic Stretching at the Single Cell Level by Atomic Force Microscopy

(2011) Takahiro Watanabe-Nakayama et al.   BIOPHYSICAL JOURNAL

(Micro)managing the mechanical microenvironment

(2011) Christopher Moraes et al.   Integrative Biology

TGF-β1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: Implication of decreased ERK signaling

(2011) Zeeshan H. Syedain et al.   JOURNAL OF BIOMECHANICS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments

(2011) Jennifer Z. Paxton et al.   TISSUE ENGINEERING PART A

Integration of statistical modeling and high-content microscopy to systematically investigate cell–substrate interactions

(2010) Wen Li Kelly Chen et al.   BIOMATERIALS

EDA-containing cellular fibronectin induces fibroblast differentiation through binding to α4β7 integrin receptor and MAPK/Erk 1/2-dependent signaling

(2010) Martin Kohan et al.   FASEB JOURNAL

Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen

(2010) Buer Sen et al.   JOURNAL OF BIOMECHANICS

Controlled cyclic stretch bioreactor for tissue-engineered heart valves

(2009) Zeeshan H. Syedain et al.   BIOMATERIALS

A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays

(2009) Christopher Moraes et al.   BIOMATERIALS

The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells

(2009) Sharan Ramaswamy et al.   BIOMATERIALS

Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics

(2009) E. J. Arnsdorf et al.   JOURNAL OF CELL SCIENCE

Osteoblast Response to Rest Periods During Bioreactor Culture of Collagen–Glycosaminoglycan Scaffolds

(2009) Niamh A. Plunkett et al.   TISSUE ENGINEERING PART A

Individually programmable cell stretching microwell arrays actuated by a Braille display

(2008) Yoko Kamotani et al.   BIOMATERIALS

Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue

(2008) Z. H. Syedain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial Signaling Microenvironments for Studying Stem Cell Fate

(2008) Christopher J. Flaim et al.   STEM CELLS AND DEVELOPMENT

Intermittent Straining Accelerates the Development of Tissue Properties in Engineered Heart Valve Tissue

(2008) Mirjam P. Rubbens et al.   TISSUE ENGINEERING PART A

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE