Apoptotic body–mediated intercellular delivery for enhanced drug penetration and whole tumor destruction

Macropinocytosis confers resistance to therapies targeting cancer anabolism

(2020) Vaishali Jayashankar et al.   Nature Communications

Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy

(2019) Cong Luo et al.   JOURNAL OF CONTROLLED RELEASE

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

(2019) Bingjun Sun et al.   Nature Communications

Engineered nanomedicines with enhanced tumor penetration

(2019) Jianxun Ding et al.   Nano Today

Lipase-Triggered Water-Responsive “Pandora's Box” for Cancer Therapy: Toward Induced Neighboring Effect and Enhanced Drug Penetration

(2018) Cheng Wang et al.   ADVANCED MATERIALS

Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

(2018) Han Lin et al.   CHEMICAL SOCIETY REVIEWS

Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation

(2018) Huicong Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

The Different Routes to Metastasis via Hypoxia-Regulated Programs

(2018) Ana Rita Nobre et al.   TRENDS IN CELL BIOLOGY

Rapidly cell-penetrating and reductive milieu-responsive nanoaggregates assembled from an amphiphilic folate-camptothecin prodrug for enhanced drug delivery and controlled release

(2017) Zhigang Xu et al.   Biomaterials Science

Domino-Like Intercellular Delivery of Undecylenic Acid-Conjugated Porous Silicon Nanoparticles for Deep Tumor Penetration

(2016) Tuying Yong et al.   ACS Applied Materials & Interfaces

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

(2016) Roger M. Phillips   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes

(2016) Kurtulus Gokduman   CURRENT DRUG TARGETS

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

(2016) Ye Tian et al.   Nanoscale Horizons

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

(2014) Cong Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lipid-Coated Cisplatin Nanoparticles Induce Neighboring Effect and Exhibit Enhanced Anticancer Efficacy

(2013) Shutao Guo et al.   ACS Nano

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

(2013) Min Hee Lee et al.   CHEMICAL REVIEWS

PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours

(2012) Mark J McKeage et al.   BMC CANCER

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

(2010) Christopher D Gregory et al.   JOURNAL OF PATHOLOGY

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology