Review
Physiology
Qian Zhou, Xingxing Lei, Shunlian Fu, Zinan Li, Yiding Chen, Cong Long, Suwen Li, Qiu Chen
Summary: Cinnamon, when used as a medical supplement, has significant effects on regulating lipid and glucose metabolism, especially in diabetic individuals, showing improvements in glycolipid levels. It can be utilized as a safe hypoglycemic and lipid-lowering supplement in clinical settings.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Psychiatry
Elena G. Kornetova, Alexander N. Kornetov, Irina A. Mednova, Anastasia A. Goncharova, Valeria Gerasimova, Ivan Pozhidaev, Anastasiia S. Boiko, Arkadiy Semke, Anton J. M. Loonen, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study reveals significant variations in the prevalence of metabolic syndrome among patients with schizophrenia in different psychiatric hospitals within the same region, highlighting the importance of individualized approaches to minimize the risk of its occurrence based on the specific characteristics of each hospital.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Keyu Guo, Liyin Zhang, Jianan Ye, Xiaohong Niu, Hongwei Jiang, Shenglian Gan, Jian Zhou, Lin Yang, Zhiguang Zhou
Summary: This study compared glycemic profiles between type 1 diabetes mellitus (T1DM) patients with and without metabolic syndrome (MetS). The results showed that T1DM patients with MetS had higher baseline HbA1c levels and higher CV values, but other glycemic metrics were comparable between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Petra Schmid, Agata Czekaj, Jurgen Frick, Tilman Steinert, Scot E. Purdon, Carmen Uhlmann
Summary: Cognitive dysfunction is commonly observed in acute psychiatric patients. The SCIP screening instrument was integrated into routine assessments for patients with psychotic and affective disorders. Results showed that more than 70% of patients had pathological cognitive performance on admission, with improvements seen at discharge, particularly in attention and speed components. Cluster analysis identified two groups, with chronically ill patients showing greater improvement in cognitive performance during their inpatient stay.
Review
Nutrition & Dietetics
Simon Paquette, Sean C. Thomas, Krishnan Venkataraman, Vasu D. Appanna, Sujeenthar Tharmalingam
Summary: Clinical trials have shown that oral probiotics intervention can improve the management of T2DM by promoting a healthy gut microbiome. Studies have demonstrated improvements in glycemic and lipid parameters, but there is inconsistency among the studies, possibly due to differences in probiotic composition, duration, and dose. Co-administration of metformin and probiotics can enhance glycemic control in T2DM patients. The overall positive findings and minimal adverse effects support further high-quality clinical trials.
Article
Medicine, General & Internal
Michal Rein, Orly Ben-Yacov, Anastasia Godneva, Smadar Shilo, Niv Zmora, Dmitry Kolobkov, Noa Cohen-Dolev, Bat-Chen Wolf, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shira Zelber-Sagi, Eran Elinav, Eran Segal
Summary: The study showed that a personalized postprandial-targeting (PPT) diet had significant effects on glycemic control and metabolic health in newly diagnosed type 2 diabetes patients, demonstrating better outcomes compared to the commonly recommended Mediterranean-style diet. Long-term PPT intervention led to improvements in multiple metabolic health parameters, supporting the clinical efficacy of this approach.
Review
Endocrinology & Metabolism
Cuihong Huang, Lifang Chen, Jiangtao Li, Juanjuan Ma, Jun Luo, Qian Lv, Jian Xiao, Pan Gao, Wen Chai, Xu Li, Ming Zhang, Fulan Hu, Dongsheng Hu, Pei Qin
Summary: Through a systematic review and meta-analysis, we found an association between mitochondrial DNA copy number and diabetes mellitus and metabolic syndrome. Lower copy numbers were associated with increased risk of diabetes mellitus and metabolic syndrome.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Food Science & Technology
Yangyang Ding, Tong Xu, Guanghua Mao, Yao Chen, Xuchun Qiu, Liuqing Yang, Ting Zhao, Xiaoxiao Xu, Weiwei Feng, Xiangyang Wu
Summary: Our study revealed that female P-T2DM mice tend to suffer from increased DEHP-induced metabolic toxicity compared with normal mice and male P-T2DM mice, primarily attributed to hepatotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Pedro Henrique Abreu da Silva, Andressa Santos Garcia, Fabio Aguiar Alves, Andre Luis Souza dos Santos, Catia Lacerda Sodre
Summary: Recent research suggests that there is a correlation between diabetes and the severity of COVID-19, possibly due to the lower levels of ACE2 receptor in diabetic patients leading to a loss of ACE2 protective effect. COVID-19 may also have a diabetogenic effect.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Niansi Pan, Shimei Yang, Xiaohong Niu
Summary: This review discusses the prevalence of MetS in LADA and the risk and role of insulin resistance in the development of LADA from the perspectives of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Environmental Sciences
Tapan Behl, Aayush Sehgal, Madhuri Grover, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
Summary: Metabolic disorders such as diabetes, obesity, and cardiovascular complications are increasing worldwide. The dysregulation of lipid and glucose transporters plays a critical role in the onset of diabetes mellitus which requires the search for new therapeutic targets. Studies suggest the involvement of ATP-binding cassette transporters in different diseases, highlighting their potential as treatment targets for insulin resistance and dysregulated glucose metabolism in diabetes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Holger Steinbrenner, Leonidas H. H. Duntas, Margaret P. P. Rayman
Summary: This review discusses the role of selenium in T2DM and its metabolic co-morbidities, emphasizing the relevance of inflammation and oxidative stress. It describes the epidemiology of selenium studies in diabetes and explains the interaction between selenium status and glucose control. According to current research, dietary selenium supplementation does not appear to be a major causal factor for the development of T2DM.
Article
Neurosciences
S. Sri Sabari, Kiruthika Balasubramani, Mahalaxmi Iyer, Harysh Winster Sureshbabu, Dhivya Venkatesan, Abilash Valsala Gopalakrishnan, Arul Narayanaswamy, Nachimuthu Senthil Kumar, Balachandar Vellingiri
Summary: Growing evidence suggests a connection between insulin dysregulation in the brain and Parkinson's disease (PD), although the link between PD and type 2 diabetes mellitus (T2DM) is still debated. Insulin plays a crucial role in brain function, and changes in insulin metabolism and signaling can lead to various brain disorders. T2DM is linked to PD and other neurodegenerative diseases, sharing pathophysiological factors such as insulin dysregulation, oxidative stress, microglial activation, and inflammation. Further research should focus on understanding the role of insulin in order to develop effective therapies for T2DM-associated PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Analytical
Weiyi Pang, Yu Xing, Camilo L. M. Morais, Qiufeng Lao, Shengle Li, Zipeng Qiao, You Li, Maneesh N. Singh, Valerio G. Barauna, Francis L. Martin, Zhiyong Zhang
Summary: Diabetes mellitus (DM) is a metabolic disease that is of increasing global concern. The diagnosis and detection of DM and pre-diabetes are currently complicated, expensive, and time-consuming. In this study, a discriminant model was developed using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy combined with principal component analysis linear discriminant analysis (PCA-LDA), which resulted in a high accuracy rate of 97% for diagnosing DM and pre-diabetes. This approach has significant clinical implications for intervention and risk reduction.
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: This study evaluated the additive and multiplicative interactions between components of Metabolic syndrome (MetS) regarding type 2 diabetes mellitus. The results showed that the joint presence of certain components had a stronger association with the prevalence of type 2 diabetes mellitus in adolescents.
Article
Psychology, Clinical
Rebecca Martland, Scott Teasdale, Robin M. Murray, Poonam Gardner-Sood, Shubulade Smith, Khalida Ismail, Zerrin Atakan, Kathryn Greenwood, Brendon Stubbs, Fiona Gaughran
Summary: This study found that patients with psychosis have poor dietary quality, low physical activity levels, and spend significant time sitting. Negative symptoms were associated with lower levels of physical activity and increased sedentary behavior. These findings highlight the importance of multidisciplinary lifestyle interventions targeted at improving eating habits and promoting physical activity among individuals with psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Lucas Melo Neves, Raphael Ritti-Dias, Valeria Juday, Raquel Marquesini, Aline Mendes Gerage, Gilberto Candido Laurentino, Renato Hoffmann Nunes, Brendon Stubbs, Carlos Ugrinowitsch
Summary: Brain atrophy, a decrease in brain volume, is associated with cognitive health in older adults. Insufficient moderate and vigorous physical activity (MVPA) has been linked to lower brain volume. This study found that meeting weekly MVPA recommendations helps preserve the volume of over 30 brain areas and structures in older adults. Additionally, cardiorespiratory fitness is an important predictor of brain volume preservation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Psychiatry
Wolfgang Marx, Sam H. Manger, Mark Blencowe, Greg Murray, Fiona Yan-Yee Ho, Sharon Lawn, James A. Blumenthal, Felipe Schuch, Brendon Stubbs, Anu Ruusunen, Hanna Demelash Desyibelew, Timothy G. Dinan, Felice Jacka, Arun Ravindran, Michael Berk, Adrienne O'Neil
Summary: This study aims to provide clinicians with evidence-based recommendations and implementation considerations for lifestyle-based mental health care for adults with Major Depressive Disorder (MDD). The study conducted systematic literature searches and formed nine recommendations, including physical activity, relaxation techniques, work-directed interventions, sleep, and mindfulness-based therapies. The study also emphasized the importance of implementing this approach with input from allied health professionals and support networks, and delivering interventions using a biopsychosocial-cultural framework.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Substance Abuse
Eugenia Romano, Ruimin Ma, Davy Vancampfort, Lee Smith, Joseph Firth, Marco Solmi, Nicola Veronese, Brendon Stubbs, Ai Koyanagi
Summary: This study examined the association between cannabis use, fast-food consumption, overweight, and obesity among adolescents in 28 countries. The results showed a significant association between cannabis use and fast-food consumption, but no association with overweight and obesity. There was moderate heterogeneity among countries for obesity, and positive associations between cannabis use and obesity were observed in the Bahamas, Bangladesh, Namibia, and Nepal.
JOURNAL OF SUBSTANCE USE
(2023)
Article
Psychiatry
Marc De Hert, Erik Thys, Kirsten Catthoor, Kris van den Broeck, Frieda Matthys, Kristof Vansteelandt, Johan Detraux
Summary: Belgium is one of the few countries where euthanasia for psychiatric disorders is legal. A case of euthanasia involving a woman with borderline personality disorder and/or autism led to a trial for murder by poisoning. A content analysis of news coverage found that the majority of articles were neutral and focused on legal aspects of the case.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Clare E. Weeden, Velimir Gayevskiy, Claire Marceaux, Daniel Batey, Tania Tan, Kenta Yokote, Nina Tubau Ribera, Allison Clatch, Susan Christo, Charis E. Teh, Andrew J. Mitchell, Marie Trussart, Lucille C. Rankin, Andreas Obers, Jackson A. McDonald, Kate D. Sutherland, Varun J. Sharma, Graham Starkey, Rohit D'Costa, Phillip Antippa, Tracy Leong, Daniel Steinfort, Louis Irviing, Charles Swanton, Claire L. Gordon, Laura K. Mackay, Terence P. Speed, Daniel H. D. Gray, Marie-Liesse Asselin-Labat
Summary: Tissue-resident memory T (TRM) cells play a crucial role in local immune defense against infection and cancer progression. This study shows that chronic inflammation affects TRM activation and TRM cells present in tissues prior to tumor onset impact cancer evolution. In preclinical models, pre-existing TRM-like cells enhance immune cell recruitment, leading to tumor immune evasion and resistance to immune checkpoint inhibitors. These findings highlight the importance of TRM-like activity in shaping tumor immunogenicity and influencing immunotherapy outcomes.
Article
Rehabilitation
Nathalie Swinnen, Eling D. de Bruin, Vania Guimaraes, Chantal Dumoulin, Jacqueline De Jong, Riekje Akkerman, Mathieu Vandenbulcke, Brendon Stubbs, Davy Vancampfort
Summary: The study aims to explore the feasibility of using an exergame prototype for individuals with major neurocognitive disorder (MNCD) residing in a long-term care facility. The results suggest that the exergame prototype is accepted by individuals with MNCD and can have positive effects when they receive extensive guidance.
DISABILITY AND REHABILITATION
(2023)
Review
Rehabilitation
Davy Vancampfort, Tine Van Damme, Vanessa Albanio Machado, Ryan L. McGrath, Brendon Stubbs, Felipe B. Schuch
Summary: Based on studies of fibromyalgia patients, sedentary behavior is associated with pain, fatigue, and a more severe impact of the disease, independent of physical activity levels. However, little attention has been given to how to assess sedentary behavior in this population.
DISABILITY AND REHABILITATION
(2023)
Article
Psychiatry
Kirsten Catthoor, Marc De Hert, Hans De Loof, Ingrid Jongeneelen, Yves Wuyts, Kris van den Broeck
Summary: The bidirectional relationship between poverty and poor physical and mental health is well-known. However, there is a lack of knowledge about poverty among physicians, leading to reduced quality of medical care for this target group. We suggest a 10-point action plan for policymakers, educational institutions, and physicians.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Thanavadee Prachason, Irem Mutlu, Laura Fusar-Poli, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Jim van Os, Bart P. F. Rutten, Lotta-Katrin Pries, Sinan Guloksuz
Summary: The purpose of this study was to explore gender differences in the associations between childhood adversity subtypes and psychiatric symptoms in the general population. The results showed that overall childhood adversity was significantly associated with overall psychopathology, regardless of gender. However, differential associations were found between specific types of childhood adversity and symptom manifestation, with abuse being particularly associated with psychopathology in women and neglect being associated with psychopathology in men.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Victor Mazereel, Kristof Vansteelandt, Claudia Menne-Lothmann, Jeroen Decoster, Catherine Derom, Evert Thiery, Bart P. F. Rutten, Nele Jacobs, Jim van Os, Marieke Wichers, Marc De Hert, Davy Vancampfort, Ruud van Winkel
Summary: Childhood adversity and psychiatric symptoms are associated with decreased global self-esteem as well as increased self-esteem instability. Childhood adversity moderates the association between psychiatric symptoms and self-esteem outcomes.
JOURNAL OF CLINICAL PSYCHOLOGY
(2023)
Review
Sport Sciences
Andreas Heissel, Darlene Heinen, Luisa Leonie Brokmeier, Nora Skarabis, Maria Kangas, Davy Vancampfort, Brendon Stubbs, Joseph Firth, Philip B. Ward, Simon Rosenbaum, Mats Hallgren, Felipe Schuch
Summary: This study examined the efficacy of exercise in treating depression and depressive symptoms, and found significant effects of exercise interventions on improving depressive symptoms. Additionally, supervised exercise interventions and higher intensity aerobic exercise showed more significant improvements in depressive symptoms.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Meeting Abstract
Psychiatry
T. Prachason, I. Mutlu, L. Fusar-Poli, C. Menne-Lothmann, J. Decoster, R. van Winkel, D. Collip P. Delespaul, M. De Hert, C. Derom, E. Thiery, N. Jacobs, M. Wichers, J. van Os, B. P. F. Rutten, L. -K. Pries, S. Guloksuz
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
K. Van Den Broeck, K. Catthoor, J. Luykx, M. De Hert, P. Niemegeers, H. Peeters, W. Krudop, J. Detraux
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
J. Bahbouhova, M. V. Cade, A. T. De Sadeleer, C. Dibbets, L. -Q. Herrmann, P. O. F. Hovens, B. M. Jakson, R. C. Reising, C. Menne-Lothmann, J. Decoster, R. van Winkel, D. Collip, P. Delespaul, M. De Hert, C. Derom, E. Thiery, N. Jacobs, M. Wichers, J. van Os, B. P. F. Rutten, S. Guloksuz, B. Klingenberg
EUROPEAN PSYCHIATRY
(2023)
