Review
Endocrinology & Metabolism
Yanfei Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, Pu Xia
Summary: Sphingolipids play a crucial role in cell membrane structure and intracellular signaling pathways. Sphingosine kinase (SphK) is an important enzyme in sphingolipid metabolism, with implications in both physiological and pathological processes, including type 2 diabetes mellitus (T2D). There is ongoing debate about the specific role of SphK in T2D, but it is believed to be a potential target for future anti-diabetes therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hubert Zywno, Wiktor Bzdega, Adrian Kolakowski, Piotr Kurzyna, Ewa Harasim-Symbor, Klaudia Sztolsztener, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Summary: Coumestrol significantly reduces the accumulation of sphingolipids in insulin-resistant hepatocytes and promotes the expression of fatty acid transport proteins, improving hepatic insulin resistance. Additionally, Coumestrol alters the sphingolipid salvage pathway, leading to excessive sphingolipid deposition.
Article
Biochemistry & Molecular Biology
Shahanas Chathoth, Mona H. Ismail, Hanan M. Alghamdi, Hazem Mohamed Zakaria, Khairi Ahmed Hassan, Saeed Alshomimi, Chittibabu Vatte, Cyril Cyrus, Hind S. Alsaif, Ahmed Mostafa, Heba Shaaban, Amein Al Ali
Summary: This study found that C16-ceramide levels were significantly increased in the obese-diabetic group, and the overexpression of the serine palmitoyl transferases enzyme subunit SPT1 may play a key role in generating C16-ceramide through the de novo pathway.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Multidisciplinary Sciences
Tiina Ohman, Jaakko Teppo, Neeta Datta, Selina Makinen, Markku Varjosalo, Heikki A. Koistinen
Summary: The study found that there were downregulations of proteins related to mitochondrial electron transport or respiratory chain complex assembly in skeletal muscle of patients with type 2 diabetes (T2D), as well as a similar decreasing trend in muscles of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) individuals. Additionally, phosphoproteomic analysis revealed altered phosphorylation in several signaling pathways in muscles of IFG, IGT, and T2D patients.
Review
Endocrinology & Metabolism
Emma K. Rautenberg, Yassin Hamzaoui, Dawn K. Coletta
Summary: Type 2 diabetes (T2D) and obesity present major challenges in public health. Understanding the molecular mechanisms contributing to these metabolic disorders, particularly insulin resistance, is crucial. Impaired mitochondria structure and function are common features in insulin-resistant individuals with T2D or obesity, potentially due to epigenetic regulation of mitochondrial and nuclear-encoded genes. Investigating mitochondrial abnormalities is important for gaining insights into the pathogenesis of diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Klaudia Berk, Karolina Konstantynowicz-Nowicka, Tomasz Charytoniuk, Ewa Harasim-Symbor, Adrian Chabowski
Summary: Available data suggests that cannabidiol (CBD) can improve symptoms of insulin resistance by modulating sphingolipid concentrations. CBD reduces ceramide content in adipose tissues, enhancing insulin sensitivity. Therefore, CBD may be considered as a potential therapeutic strategy for treating insulin resistance and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adrian Kolakowski, Piotr F. Kurzyna, Hubert Zywno, Wiktor Bzdega, Ewa Harasim-Symbor, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Summary: The study demonstrated that VK2 activates the ceramide de novo synthesis pathway and enhances fatty acid uptake, providing substrates for sphingolipid synthesis. Additionally, the increase in sphingolipids, mainly sphinganine, inhibits the phosphorylation of insulin pathway proteins, leading to insulin resistance development.
Article
Medicine, Research & Experimental
Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin, Pu Xia
Summary: Circulating levels of dhS1P and dhS1P/dhSph ratio are strongly associated with increased risk of T2DM, and could serve as a useful biomarker for predicting incident T2DM in normoglycemic populations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Zhipeng Li, Manoj Gurung, Richard R. Rodrigues, Jyothi Padiadpu, Nolan K. Newman, Nathan P. Manes, Jacob W. Pederson, Renee L. Greer, Stephany Vasquez-Perez, Hyekyoung You, Kaito A. Hioki, Zoe Moulton, Anna Fel, Dominic De Nardo, Amiran K. Dzutsev, Aleksandra Nita-Lazar, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun
Summary: Microbiota contribute to the induction of type 2 diabetes by causing OXPHOS damage in white adipose tissue. Mmp12(+) macrophages link microbiota-dependent inflammation and OXPHOS damage in WAT.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Sevgican Demir, Peter P. Nawroth, Stephan Herzig, Bilges Ekim Ustunel
Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.
Review
Endocrinology & Metabolism
Nicole A. Teaney, Nicole E. Cyr
Summary: FoxO1 proteins play an important role in metabolic tissues associated with type 2 diabetes (T2D), but their specific roles are controversial. The effects of FoxO1 activity vary in different tissue types, with enhanced FoxO1 alleviating symptoms in some tissues while exacerbating them in others. Current research focuses on studying FoxO1's impact on insulin secretion, hepatic glucose production, lipogenesis, and muscle atrophy. Additionally, FoxO1 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Article
Biochemistry & Molecular Biology
Xiaodong Ge, Xiaoyu He, Zhenshan Lin, Yuxian Zhu, Xiaoqin Jiang, Liyuan Zhao, Feng Zeng, Ligen Chen, Wei Xu, Tingting Liu, Zhigang Chen, Chao Zhao, Ying Huang, Bin Liu
Summary: By modifying the structure of luteolin, the compounds DAGL and DAGL · Cr were found to improve hyperglycemia in T2DM mice. They achieved this by improving pancreatic islet function, regulating serum and liver biochemical indicators, repairing damaged tissues, and regulating the PI3K/AKT-1 signaling pathway. Moreover, DAGL and DAGL · Cr also regulated the structure of the intestinal microbiota and increased the content of short-chain fatty acids (SCFA) in the feces, alleviating the symptoms of hyperglycemia in T2DM mice.
Review
Nutrition & Dietetics
Jessica Lewgood, Barbara Oliveira, Marie Korzepa, Scott C. Forbes, Jonathan P. Little, Leigh Breen, Robert Bailie, Darren G. Candow
Summary: The prevalence of Type 2 diabetes (T2D) is increasing and creating a large economic burden. This review critically evaluates the effects of various dietary strategies on diabetes management as well as examines several purported supplements aiming to improve glucose control and body composition.
Review
Endocrinology & Metabolism
Haocheng Zhang, Yan Gu, Qiaojian Gang, Jing Huang, Qian Xiao, Xiaoqin Ha
Summary: Type 2 diabetes is a metabolic disease with increasing incidence worldwide. The role of epigenetics, particularly N6-methyladenosine (m6A) modification, has been shown to be important in the disease. Understanding the metabolic roles of m6A in organs, the involved signaling pathways, and the effects of clinical drugs on T2D would contribute to the search for new biomarkers and therapeutic approaches for the disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Marcin Baranowski, Piotr Zabielski, Agnieszka U. Blachnio-Zabielska, Ewa Harasim, Adrian Chabowski, Jan Gorski
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Agnieszka U. Blachnio-Zabielska, Piotr Zabielski, Michael D. Jensen
JOURNAL OF LIPID RESEARCH
(2013)
Article
Multidisciplinary Sciences
Piotr Zabielski, Agnieszka Urszula B. O. Achnio-Zabielska, Beata Wojcik, Adrian Chabowski, Jan Gorski
Review
Biochemistry & Molecular Biology
Arkadiusz Zbikowski, Agnieszka Blachnio-Zabielska, Mauro Galli, Piotr Zabielski
Summary: Adipose tissue acts as an endocrine organ in energy metabolism management through secretion of adipokines, hormones, and exosomes. Pathological processes like obesity can disrupt this secretory function, leading to dysfunction and contributing to metabolic changes and insulin resistance. Understanding the production, release, and content of exosomes from adipose tissue may be crucial in elucidating its role in metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mauro Galli, Ahsan Hameed, Arkadiusz Zbikowski, Piotr Zabielski
Summary: Aquaporins play an important role in transporting water and small molecules across biological membranes, and recent discoveries suggest their potential involvement in insulin resistance and type-2 diabetes.
Article
Cell Biology
Agnieszka U. Blachnio-Zabielska, Kamila Roszczyc-Owsiejczuk, Monika Imierska, Karolina Pogodzinska, Pawel Rogalski, Jaroslaw Daniluk, Piotr Zabielski
Summary: Skeletal muscle lipid metabolism plays a crucial role in insulin resistance, and the accumulation of ceramides is considered to be one of the causes. The study found that the accumulation of C18:0-Cer plays a key role in inducing skeletal muscle insulin resistance.
Article
Cell Biology
Monika Imierska, Piotr Zabielski, Kamila Roszczyc-Owsiejczuk, Emilia Sokolowska, Karolina Pogodzinska, Iwona Kojta, Agnieszka Blachnio-Zabielska
Summary: Skeletal muscles play a crucial role in insulin-stimulated glucose uptake, and a high-fat diet can lead to metabolic changes in muscles, including the development of insulin resistance. Accumulation of biologically active lipids, particularly ceramides, in muscles is shown to be important in the development of insulin resistance. Silencing the gene responsible for ceramide synthesis can reduce ceramide accumulation and improve the insulin signaling pathway.
Article
Medicine, General & Internal
Joanna Goralska, Urszula Razny, Philip C. Calder, Anna Gruca, Caroline E. Childs, Piotr Zabielski, Aldona Dembinska-Kiec, Maciej Banach, Bogdan Solnica, Malgorzata Malczewska-Malec
Summary: Elevated GIP levels in obese patients can be improved by n-3 PUFA supplementation, resulting in metabolic benefits and improved glucose tolerance through the reduction of saturated and monounsaturated fatty acids.
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Arkadiusz Zbikowski, Piotr Zabielski, Urszula Chlabicz, Patrycja Sadowska, Karolina Pogodzinska, Agnieszka U. Blachnio-Zabielska
Summary: Silencing of SPHK1 expression decreases S1P content and increases apoptosis in HCT-116 colorectal cancer cells, while silencing of SGPL1 expression increases both S1P and Cer content and modulates Cathepsin-D. The S1P/Cer ratio seems to play a crucial role in cellular apoptosis and CRC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)