NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage

The Role of NRF2 in Bone Metabolism – Friend or Foe?

(2022) Jie Han et al.   Frontiers in Endocrinology

Inhibition of DNA methylation derepresses PPARγ and attenuates pulmonary fibrosis

(2021) Ai Wei et al.   BRITISH JOURNAL OF PHARMACOLOGY

Upregulation of microRNA‐200a in bone marrow mesenchymal stem cells enhances the repair of spinal cord injury in rats by reducing oxidative stress and regulating Keap1/Nrf2 pathway

(2020) Xianxiang Wang et al.   ARTIFICIAL ORGANS

Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)

(2020) Haishan Zhou et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty

(2020) Rita Hameister et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

(2020) Sumi Lee et al.   MEDICINAL CHEMISTRY RESEARCH

Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis

(2020) Yongxian Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ROS signaling cascades: dual regulations for osteoclast and osteoblast

(2020) Huaqiang Tao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice

(2019) Yanxia Chen et al.   MICROVASCULAR RESEARCH

Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment

(2019) Stuart B. Goodman et al.   Journal of Clinical Medicine

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The phagocyte respiratory burst: Historical perspectives and recent advances

(2017) David C. Thomas   IMMUNOLOGY LETTERS

Epigenetics and Oxidative Stress in Aging

(2017) Amy Guillaumet-Adkins et al.   Oxidative Medicine and Cellular Longevity

Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox

(2017) Bharatwaj Sowrirajan et al.   Scientific Reports

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Resveratrol Protects against Titanium Particle-Induced Aseptic Loosening Through Reduction of Oxidative Stress and Inactivation of NF-κB

(2016) Guotian Luo et al.   INFLAMMATION

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis

(2015) Zhenheng Wang et al.   Autophagy

Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation

(2015) Yong-Xin Sun et al.   BONE

Current Failure Mechanisms After Knee Arthroplasty Have Changed: Polyethylene Wear Is Less Common in Revision Surgery

(2015) Kathi Thiele et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Nrf2 is a novel regulator of bone acquisition

(2014) Cheol Kyu Park et al.   BONE

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms

(2013) J. Gallo et al.   Acta Biomaterialia

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

(2013) Vijay Krishna Raghunathan et al.   BIOMATERIALS

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Inhibitory effect of (-)-epigallocatechin gallate on titanium particle-induced TNF-α release andin vivoosteolysis

(2011) Shan Jin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of reactive oxygen species scavenging enzymes in the development of septic loosening after total hip replacement

(2011) K.-T. Peng et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in bone remodelling and disease

(2009) Fabien Wauquier et al.   TRENDS IN MOLECULAR MEDICINE