Dysregulation of Ambient Glutamate and Glutamate Receptors in Epilepsy: An Astrocytic Perspective

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

(2020) Pavel Klein et al.   EPILEPSIA

LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons

(2020) Jing-Jing Zhou et al.   EXPERIMENTAL NEUROLOGY

ECS Dynamism and Its Influence on Neuronal Excitability and Seizures

(2019) Robert Colbourn et al.   NEUROCHEMICAL RESEARCH

Neuron–glia interactions in the pathophysiology of epilepsy

(2019) Dipan C. Patel et al.   NATURE REVIEWS NEUROSCIENCE

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status

(2019) Roberta Celli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke

(2019) Junhua Yang et al.   NEURON

Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models

(2019) Karine Leclercq et al.   EPILEPSIA

Sulfasalazine decreases mouse cortical hyperexcitability

(2019) Oscar Alcoreza et al.   EPILEPSIA

Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity

(2019) Jaycie L. Loewen et al.   EXPERIMENTAL NEUROLOGY

Glia-neuron interactions underlie state transitions to generalized seizures

(2019) Carmen Diaz Verdugo et al.   Nature Communications

Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue

(2018) Jan Tønnesen et al.   CELL

Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

(2018) Hongying Zhu et al.   CELL

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

(2018) Balázs Pál   CELLULAR AND MOLECULAR LIFE SCIENCES

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model

(2018) Cameron S. Metcalf et al.   EPILEPSIA

LRRC8A is essential for swelling-activated chloride current and for regulatory volume decrease in astrocytes

(2018) Francesco Formaggio et al.   FASEB JOURNAL

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

(2018) Sigrid Ottestad-Hansen et al.   GLIA

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

(2018) Luisa Di Menna et al.   NEUROPHARMACOLOGY

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Ketamine for Refractory Status Epilepticus: A Systematic Review

(2018) Anna Rosati et al.   CNS DRUGS

Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents

(2018) Marta Gómez-Gonzalo et al.   GLIA

Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model

(2018) Mustafa Q Hameed et al.   CEREBRAL CORTEX

Conditional Knockout of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake

(2018) Anthony D. Umpierre et al.   JOURNAL OF NEUROSCIENCE

Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

(2017) Cameron S. Metcalf et al.   EPILEPSIA

Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression

(2017) Amber L. LaCrosse et al.   JOURNAL OF NEUROSCIENCE

Turning down the volume: Astrocyte volume change in the generation and termination of epileptic seizures

(2017) Thomas R. Murphy et al.   NEUROBIOLOGY OF DISEASE

mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex

(2017) Elyza Kelly et al.   NEUROPSYCHOPHARMACOLOGY

Metabotropic glutamate receptors and neurodegenerative diseases

(2017) Fabiola M. Ribeiro et al.   PHARMACOLOGICAL RESEARCH

Astrocytic control of synaptic function

(2017) Thomas Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond

(2016) Wolfgang Löscher et al.   CNS DRUGS

Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis

(2016) Feng Qian et al.   Current Neuropharmacology

Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy

(2016) Longze Sha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation

(2016) Jiajia Li et al.   Scientific Reports

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus

(2015) Kelli Lauderdale et al.   ASN Neuro

Perampanel: A Review in Drug-Resistant Epilepsy

(2015) James E. Frampton   DRUGS

Brivaracetam augments short-term depression and slows vesicle recycling

(2015) Xiaofeng Yang et al.   EPILEPSIA

Enhanced astroglial Ca2+signaling increases excitatory synaptic strength in the epileptic brain

(2015) Carla Álvarez-Ferradas et al.   GLIA

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat

(2013) Grant S. Goodrich et al.   JOURNAL OF NEUROTRAUMA

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Glutamine Synthetase as an Astrocytic Marker: Its Cell Type and Vesicle Localization

(2013) Enrico Anlauf et al.   Frontiers in Endocrinology

Glutamate Pays Its Own Way in Astrocytes

(2013) Mary C. McKenna   Frontiers in Endocrinology

Human glioma cells induce hyperexcitability in cortical networks

(2012) Susan L. Campbell et al.   EPILEPSIA

Infiltrating Macrophages Are Key to the Development of Seizures following Virus Infection

(2012) Matthew F. Cusick et al.   JOURNAL OF VIROLOGY

Patterns of treatment response in newly diagnosed epilepsy

(2012) M. J. Brodie et al.   NEUROLOGY

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy

(2011) R.T. Ngomba et al.   NEUROPHARMACOLOGY

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Participation of metabotropic glutamate receptors in pentetrazol-induced kindled seizure

(2010) Yusuke Watanabe et al.   EPILEPSIA

(S)-Carboxy-3-Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

(2010) Christian Thomsen et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

The blood-brain barrier and glutamate

(2009) Richard A Hawkins   AMERICAN JOURNAL OF CLINICAL NUTRITION

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats

(2008) Emilio R. Garrido-Sanabria et al.   BRAIN RESEARCH

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE