Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models

PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats

(2016) Maria Domercq et al.   Theranostics

Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model

(2015) Karine Leclercq et al.   EPILEPSY & BEHAVIOR

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

(2015) Jimmy George et al.   GLIA

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus

(2015) Carmela Giordano et al.   PLoS One

Sulfasalazine Induces Autophagic Cell Death in Oral Cancer Cells via Akt and ERK Pathways

(2014) Hye-Yeon Han et al.   Asian Pacific Journal of Cancer Prevention

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Low potency and limited efficacy of antiepileptic drugs in the mouse 6Hz corneal kindling model

(2014) K. Leclercq et al.   EPILEPSY RESEARCH

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain

(2014) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

(2014) Annamaria Vezzani   Epilepsy Currents

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Issues related to development of antiepileptogenic therapies

(2013) Asla Pitkänen et al.   EPILEPSIA

Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system xc- cystine/glutamate exchanger

(2013) J.L. Newell et al.   NEUROCHEMISTRY INTERNATIONAL

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy

(2012) Marion Bankstahl et al.   BEHAVIOURAL BRAIN RESEARCH

Human glioma cells induce hyperexcitability in cortical networks

(2012) Susan L. Campbell et al.   EPILEPSIA

Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization

(2012) Manuela Mazzuferi et al.   EXPERIMENTAL NEUROLOGY

Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

(2012) Casey M. O'Dell et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice

(2009) Christine J. Müller et al.   EXPERIMENTAL NEUROLOGY

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

(2008) Asla Pitkänen et al.   EPILEPSY & BEHAVIOR

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY