2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice

(2020) Purnima Singh et al.   HYPERTENSION

PG490-88, a derivative of triptolide, suppresses ischemia/reperfusion-induced lung damage by maintaining tight junction barriers and targeting multiple signaling pathways

(2019) Hsin-Ping Pao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting F-Box Protein Fbxo3 Attenuates Lung Injury Induced by Ischemia-Reperfusion in Rats

(2019) Kuei-Yi Hung et al.   Frontiers in Pharmacology

WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice

(2019) Young Eun Kim et al.   Scientific Reports

Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1

(2019) Rodrigo Azevedo Loiola et al.   Frontiers in Endocrinology

Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients

(2019) Alessandra Colamatteo et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury

(2018) Junaid Ansari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia

(2018) Lu Liu et al.   Frontiers in Molecular Neuroscience

Endothelial progenitor cells attenuate the lung ischemia/reperfusion injury following lung transplantation via the eNOS pathway

(2018) Wei Gao et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury

(2017) Wen-I Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2-Methoxyestradiol protects against IgG immune complex-induced acute lung injury by blocking NF-κB and CCAAT/enhancer-binding protein β activities

(2017) Chunguang Yan et al.   MOLECULAR IMMUNOLOGY

Inhibition of HIF-1α decreases expression of pro-inflammatory IL-6 and TNF-α in diabetic retinopathy

(2016) Xiuhua Gao et al.   ACTA OPHTHALMOLOGICA

Formyl-Peptide Receptor 2/3/Lipoxin A4Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral InflammationCLINICAL PERSPECTIVE

(2016) Shantel A. Vital et al.   CIRCULATION

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

(2016) Giacomo Bellani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

Valproic Acid Attenuates Acute Lung Injury Induced by Ischemia–Reperfusion in Rats

(2015) Shu-Yu Wu et al.   ANESTHESIOLOGY

Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke

(2015) Helen K. Smith et al.   FASEB JOURNAL

Oxidative Stress and Lung Ischemia-Reperfusion Injury

(2015) Renata Salatti Ferrari et al.   Oxidative Medicine and Cellular Longevity

Critical Role for the NLRP3 Inflammasome during Acute Lung Injury

(2014) J. J. Grailer et al.   JOURNAL OF IMMUNOLOGY

Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

(2014) Ying-Yin Chen et al.   Biomed Research International

Proresolving and Tissue-Protective Actions of Annexin A1-Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

(2013) J. Dalli et al.   JOURNAL OF IMMUNOLOGY

Annexin A1: potential for glucocorticoid sparing in RA

(2013) Yuan H. Yang et al.   Nature Reviews Rheumatology

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation

(2012) G. S. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis

(2011) Hiromitsu Ohta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis

(2011) Alexandra Stubelius et al.   CLINICAL IMMUNOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats

(2011) Yun Li et al.   NEUROLOGICAL RESEARCH

Anticancer Agent 2-Methoxyestradiol Improves Survival in Septic Mice by Reducing the Production of Cytokines and Nitric Oxide

(2011) Ching-Hua Yeh et al.   SHOCK

Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

(2010) Shiu-Hwa Yeh et al.   BRAIN PATHOLOGY

HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium

(2010) So Ri Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Evidence for Anti-Inflammatory Properties of 2-Methoxyestradiol

(2010) F. H. W. Shand et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

2-Methoxyestradiol—Biology and mechanism of action

(2010) A.O. Mueck et al.   STEROIDS

Baicalin attenuates air embolism-induced acute lung injury in rat isolated lungs

(2009) Min-Hui Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics

(2009) Mauro Perretti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model

(2008) S. Huerta-Yepez et al.   CLINICAL IMMUNOLOGY

Intravascular FC-77 attenuates phorbol myristate acetate-induced acute lung injury in isolated rat lungs

(2008) Hung Chang et al.   CRITICAL CARE MEDICINE

Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: An effect independent of an anti-angiogenic action

(2008) Andrew C. Issekutz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Opposing regulation of neutrophil apoptosis through the formyl peptide receptor-like 1/lipoxin A4 receptor: implications for resolution of inflammation

(2008) Driss El Kebir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Isolation Protocol

(2008) Hana Oh et al.   Jove-Journal of Visualized Experiments