Journal
NANOMATERIALS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nano11041046
Keywords
biofilm; polymicrobial infections; nosocomial infections; superhydrophobic; nanomaterials; anti-biofilm surfaces
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Funding
- Fundamental Research Grant Scheme (FRGS) from the Ministry of Higher Education of Malaysia [FRGS/1/2018/STG07/IMU/03/1]
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Biofilm formation is a significant concern linked to increased morbidity and mortality, necessitating the development of novel therapeutic strategies. Physicochemical modification of biomaterials in medical devices is a promising approach to combating polymicrobial infections.
Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies.
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