Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy

Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis

(2021) Kai Jiang et al.   Protein & Cell

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells

(2020) Zipeng Xie et al.   CANCER LETTERS

24-Hour Blood Pressure-Lowering Effect of an SGLT-2 Inhibitor in Patients with Diabetes and Uncontrolled Nocturnal Hypertension: Results from the Randomized, Placebo-Controlled SACRA Study

(2019) Kazuomi Kario et al.   CIRCULATION

Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association

(2019) Umberto Campia et al.   CIRCULATION

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

(2019) Chenguang Li et al.   Cardiovascular Diabetology

Sodium‐glucose co‐transporter‐2 (SGLT‐2) inhibitors and cancer: A meta‐analysis of randomized controlled trials

(2019) Ilaria Dicembrini et al.   DIABETES OBESITY & METABOLISM

SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling

(2019) Bolin Hou et al.   Scientific Reports

Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro

(2019) Yi Yang et al.   ARCHIVES OF TOXICOLOGY

Drug-Induced Hypertension Caused by Multikinase Inhibitors (Sorafenib, Sunitinib, Lenvatinib and Axitinib) in Renal Cell Carcinoma Treatment

(2019) Nanna Bæk Møller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function: Data from the CANVAS Program

(2018) Brendon L. Neuen et al.   CIRCULATION

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

(2018) Prakash C. Thakur et al.   Journal of Translational Medicine

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

(2018) Matheus Dyczynski et al.   CANCER LETTERS

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat

(2018) Chih-Chao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

(2018) Stephen D. Wiviott et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

(2017) Lindsay DeVorkin et al.   MOLECULAR CANCER RESEARCH

Empagliflozin Limits Myocardial Infarction in Vivo and Cell Death in Vitro: Role of STAT3, Mitochondria, and Redox Aspects

(2017) Ioanna Andreadou et al.   Frontiers in Physiology

Current Drug Therapy in Chronic Heart Failure: the New Guidelines of the European Society of Cardiology (ESC)

(2017) Dominik Berliner et al.   Korean Circulation Journal

Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management

(2016) Giuseppe Curigliano et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus

(2016) Hiddo J.L. Heerspink et al.   CIRCULATION

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

(2016) Jose Luis Zamorano et al.   EUROPEAN HEART JOURNAL

Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue

(2016) Fabian Jacob et al.   PLoS One

Clinical outcomes of patients with advanced gastrointestinal stromal tumors: Safety and efficacy in a worldwide treatment-use trial of sunitinib

(2015) Peter Reichardt et al.   CANCER

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular events among 1090 cancer patients treated with sunitinib, interferon, or placebo: A comprehensive adjudicated database analysis demonstrating clinically meaningful reversibility of cardiac events

(2014) Michael S. Ewer et al.   EUROPEAN JOURNAL OF CANCER

Treatment of Hypertension and Renal Injury Induced by the Angiogenesis Inhibitor Sunitinib

(2014) Stephanie Lankhorst et al.   HYPERTENSION

Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity

(2013) V. Chintalgattu et al.   Science Translational Medicine

FDA Approval Summary: Sunitinib for the Treatment of Progressive Well-Differentiated Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors

(2012) G. M. Blumenthal et al.   ONCOLOGIST

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK)

(2010) Keith Laderoute et al.   CANCER BIOLOGY & THERAPY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis

(2009) G. Di Lorenzo et al.   ANNALS OF ONCOLOGY

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

Cardiac Toxicity of Sunitinib and Sorafenib in Patients With Metastatic Renal Cell Carcinoma

(2008) Manuela Schmidinger et al.   JOURNAL OF CLINICAL ONCOLOGY

Doppler Estimation of Reduced Coronary Flow Reserve in Mice with Pressure Overload Cardiac Hypertrophy

(2008) Craig J. Hartley et al.   ULTRASOUND IN MEDICINE AND BIOLOGY