Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

Phytochemicals from Carissa carandas with potent cytotoxic and anti-inflammatory activities

(2021) Zarina Bano et al.   NATURAL PRODUCT RESEARCH

TMEM16A-inhibitor loaded pH-responsive nanoparticles: a novel dual-targeting antitumor therapy for lung adenocarcinoma

(2020) Shuai Guo et al.   BIOCHEMICAL PHARMACOLOGY

Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy

(2020) Shuai Guo et al.   PHARMACOLOGICAL RESEARCH

Benzophenanthridine alkaloids suppress lung adenocarcinoma by blocking TMEM16A Ca2+-activated Cl− channels

(2020) Gaohua Zhang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Role of FAT10 in Alcoholic Hepatitis Pathogenesis

(2020) Yue Jia et al.   Biomedicines

Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells

(2020) Varuni Colamba Pathiranage et al.   Journal of Integrative Medicine-JIM

Molecular mechanism of CaCCinh-A01 inhibiting TMEM16A channel

(2020) Sai Shi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Appropriate chemopreventive strategy for anti-tubercular therapy related liver injury is unsettled: results from a systematic review and network meta-analysis

(2020) Anupam Kumar Singh et al.   Expert Review of Clinical Pharmacology

Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway

(2019) Yayun Liu et al.   Acta Pharmaceutica Sinica B

Lung Cancer

(2019) Faria Nasim et al.   MEDICAL CLINICS OF NORTH AMERICA

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

Patient preferences of chemotherapy treatment options and tolerance of chemotherapy side effects in advanced stage lung cancer

(2019) K. M. Islam et al.   BMC CANCER

The multifaceted role of TMEM16A in cancer

(2019) David Crottès et al.   CELL CALCIUM

Entering the spotlight: Chitosan oligosaccharides as novel activators of CaCCs/TMEM16A

(2019) Shuai Guo et al.   PHARMACOLOGICAL RESEARCH

The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A

(2019) Shuai Guo et al.   BIOPHYSICAL JOURNAL

Phase II study of nab‐paclitaxel + carboplatin for patients with non‐small‐cell lung cancer and interstitial lung disease

(2019) Hirotsugu Kenmotsu et al.   CANCER SCIENCE

Anti-Cancer Activity of a 5-Aminopyrazole Derivative Lead Compound (BC-7) and Potential Synergistic Cytotoxicity with Cisplatin against Human Cervical Cancer Cells

(2019) Bresler Swanepoel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Improvement in Overall Survival in a Randomized Study That Compared Dacomitinib With Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer and EGFR-Activating Mutations

(2018) Tony S. Mok et al.   JOURNAL OF CLINICAL ONCOLOGY

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

(2018) Claudia Allemani et al.   LANCET

Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

(2018) Jean-Charles Soria et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Milk thistle (Silybum marianum ): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

(2018) Ludovico Abenavoli et al.   PHYTOTHERAPY RESEARCH

Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects

(2018) Shuai Guo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator

(2018) Zohreh Jahanafrooz et al.   LIFE SCIENCES

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

(2017) Hui Wang et al.   Molecular Cancer

Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum

(2017) Shuai Guo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment

(2016) Guowei Gu et al.   CURRENT OPINION IN PHARMACOLOGY

Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: a review

(2016) Keiju Aokage et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib

(2016) Hiroyuki Kobayashi et al.   MEDICAL ONCOLOGY

ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer

(2015) Anke Bill et al.   Oncotarget

Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

(2015) Linghan Jia et al.   PLoS One

The Ca2+-activated Cl−channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

(2014) Zhiqiang Qu et al.   Cancer Medicine

A Rapid and Simple Chromatographic Separation of Diastereomers of Silibinin and Their Oxidation to Produce 2,3-Dehydrosilybin Enantiomers in an Optically Pure Form

(2013) Giovanni Di Fabio et al.   PLANTA MEDICA