Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Review
Chemistry, Multidisciplinary
Zi'an Wang, Xuan Wang, Jian-Bo Wan, Fujian Xu, Nana Zhao, Meiwan Chen
Summary: This review summarizes the latest progress of NIR-II optical imaging for angiography, including fluorescence imaging, photoacoustic imaging, and optical coherence tomography. It highlights the optimization and application of probes in vascular imaging.
Review
Chemistry, Multidisciplinary
Yingying Chen, Liru Xue, Qingqing Zhu, Yanzhi Feng, Mingfu Wu
Summary: NIR-II fluorescence imaging technology has high imaging performance, significantly overcoming the difficulties in traditional imaging, and is widely regarded as the most promising in vivo fluorescence imaging technology.
FRONTIERS IN CHEMISTRY
(2021)
Article
Acoustics
Zhen Jiang, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang
Summary: This review summarizes NIR-II organic contrast agents reported in the past decade for photoacoustic and fluorescence imaging, and discusses the rational design of NIR-II fluorophores to improve imaging contrast and resolution. A wide variety of applications using NIR-II dyes have been realized, including imaging of tumors, lymphatics, brains, intestines, and others. Targeted imaging and activable imaging with improved resolution and sensitivity have been demonstrated by innovative chemical modification of NIR-II dyes.
Article
Materials Science, Multidisciplinary
Baisong Chang, Hao Zhu, Yifan Wu, Shaolong Wu, Liqin Zhang, Chunrong Qu, Ying Ren, Zhen Cheng
Summary: The study introduces a novel strategy for selective signal activation through aggregation-induced emission-mode-switching, enabling the probe to switch from weak fluorescence to strong NIR-II phosphorescence. This new approach utilizes Copper indium selenium (Cu-In-Se) quantum dots, which exhibit over 2.7 x 10^3-fold increase in luminescent lifetime when aggregated, and shows potential for designing smart NIR-II probes for advanced imaging applications.
ADVANCED OPTICAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Tian Wang, Yingying Chen, Bo Wang, Xiaofan Gao, Mingfu Wu
Summary: This review introduces the role of second near-infrared region (NIR-II) fluorescence imaging in cancer diagnosis and summarizes its applications in cancer therapy. With the development of fluorescence imaging systems and fluorescent probes, quick tumor detection, margin definition, and individualized therapy can be achieved, leading to improved accuracy in cancer diagnosis and treatment.
Article
Engineering, Biomedical
Haoying Huang, Ruijuan Qiu, Hongchao Yang, Feng Ren, Feng Wu, Yejun Zhang, Hong Zhang, Chunyan Li
Summary: Near-infrared (NIR) fluorescence imaging technology has been extensively used in biomedical imaging, with recently developed ratiometric fluorescent probes providing more accurate detection feedback. These probes can be applied in various fields in vivo biological imaging, such as molecular detection, pH and temperature measurement, drug delivery monitoring and treatment evaluation.
BIOMEDICAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Menglin Wu, Xue Li, Xiaoyu Mu, Xuening Zhang, Hao Wang, Xiao-Dong Zhang
Summary: This review provides an overview of the development of near-infrared-II (NIR-II) fluorescence imaging for studying physiological and pathological activities in living organisms. It highlights the limitations of fluorescence penetration depth and discusses the integration of NIR-II fluorescence imaging with other imaging modes to create multimodal imaging for deeper anatomical information.
Review
Materials Science, Multidisciplinary
Mingxia Jiao, Arsenii S. Portniagin, Xiliang Luo, Lihong Jing, Buxing Han, Andrey L. Rogach
Summary: Semiconductor nanocrystals emitting in the NIR-II window are promising fluorophores for biomedical applications due to their high brightness, adjustable emission wavelength, and stability. This review summarizes recent advances in the synthesis of NIR-II emitting semiconductor nanocrystals and highlights efforts to improve their emission intensity and photostability. It also provides examples of their applications in biomedical imaging, therapy, and surgery.
ADVANCED OPTICAL MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Yanling Yang, Yang Xie, Fan Zhang
Summary: In vivo multiplexed bioimaging in the second near-infrared window (NIR-II) has become a growing technology in medical diagnosis and clinical applications due to its advantages of multi-color observations, high sensitivity, deeper penetration, high spatiotemporal resolution, and high throughput. Various types of nanoprobes, including quantum dots, lanthanide downconversion nanoparticles, and organic fluorophores, have shown great potential for intravital imaging and disease diagnosis. This review summarizes recent advances in NIR-II-emitted nanoprobes for intravital multiplexed bioimaging and discusses the challenges and opportunities in designing novel long-wavelength nanoprobes for deep-tissue imaging.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Baisong Chang, Jie Chen, Jiasheng Bao, Kangfeng Dong, Si Chen, Zhen Cheng
Summary: In recent years, advances in synthesis chemistries and imaging instruments have led to significant progress in optical bioimaging in the second near-infrared window (NIR-II), benefiting large-scale biomedical applications. However, most NIR-II probes suffer from high background noise, leading to weak detection precision. Therefore, developing NIR-II optical probes that can efficiently activate their luminescent signal and suppress background interference has become a promising research frontier.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Physiology
Tian Wang, Yingying Chen, Bo Wang, Mingfu Wu
Summary: Visualizing biological tissues in vivo at a cellular or subcellular resolution is crucial for exploring molecular signaling and cell behaviors. In vivo imaging, particularly using near-infrared region fluorophores, provides quantitative and dynamic visualization in biology and immunology. Advancements in chemical materials and physical optoelectronics have led to the emergence of new NIR-II microscopy techniques for bioimaging, such as confocal and multiphoton microscopy, LSFM, and wide-field microscopy.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jing Mu, Ming Xiao, Yu Shi, Xuewen Geng, Hui Li, Yuxin Yin, Xiaoyuan Chen
Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Jiwon Kim, Sangwon Baek, Jae Yong Park, Kwang Ho Kim, Jong-Lam Lee
Summary: The translated text describes a multilayer film technology for energy-saving windows that selectively blocks near-infrared while maintaining high transmittance in visible light.
Article
Optics
Zhe Feng, Tao Tang, Tianxiang Wu, Xiaoming Yu, Yuhuang Zhang, Meng Wang, Junyan Zheng, Yanyun Ying, Siyi Chen, Jing Zhou, Xiaoxiao Fan, Shengliang Li, Mingxi Zhang, Jun Qian
Summary: The study improved the definition of the NIR-II window, proposed the NIR-III window, identified the optical range suitable for in vivo imaging, and provided excellent optical sectioning capability and imaging depth for brain fluorescence microscopy examinations.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Geriatrics & Gerontology
Linxin Liu, Anna Zhu, Chang Shu, Yi Zeng, John S. Ji
Summary: This study found a gene-environment interaction between FOXO gene and residential greenness on mortality in the Chinese Longitudinal Healthy Longevity Survey. Participants carrying two minor alleles of FOXO3A SNPs had lower mortality risk. Contemporaneous NDVI was associated with lower mortality risk, and the protective effect of greenness was stronger for two minor allele carriers.
REJUVENATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Dae Bum Kim, Joon Sung Kim, Cheal Wung Huh, Dae Won Ma, Jeong-Seon Ji, Byung-Wook Kim, Hwang Choi
Summary: The study compared the efficiency and safety of different sedation methods for outpatient colonoscopy, finding propofol to be superior in terms of efficiency and patient satisfaction compared to midazolam bolus or titrated administration.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu, Jiansong Ji
Summary: The study demonstrated that SNHG6 is highly expressed in HCC tissues and knocking down SNHG6 reduces proliferation, migration, and invasion abilities of cells in vitro. The research also revealed the direct binding of miR-6509-5p to SNHG6 and the regulation of HIF1A expression through the SNHG6/miR-6509-5p axis. Furthermore, down-regulation of SNHG6 significantly decreased tumor growth ability of Huh7 cells in vivo, suggesting the potential of SNHG6/miR-6509-5p/HIF1A axis as therapeutic targets for HCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Mei Feng, Zhongwei Zhao, Mengxuan Yang, Jiansong Ji, Di Zhu
Summary: Colorectal cancer is the leading cause of cancer death worldwide, with therapeutic strategies including surgery, chemotherapy, radiotherapy, and other approaches. T-cell-based immunotherapy has shown promising responses in other cancers, but most CRC patients are resistant to immunotherapy, chemotherapy, and targeted therapy. Immune checkpoint inhibitors have shown encouraging results in some cancers, but are only effective for a subset of CRC patients with microsatellite instability. Other immunotherapies are currently being used against CRC.
Article
Nanoscience & Nanotechnology
Gaofeng Shu, Chenying Lu, Zhixian Wang, Yuyin Du, Xiaoling Xu, Min Xu, Zhongwei Zhao, Minjiang Chen, Yiyang Dai, Qiaoyou Weng, Shiji Fang, Kai Fan, Di Liu, Yongzhong Du, Jiansong Ji
Summary: The study developed kidney-targeted OSA-Fucoidan/Cur micelles with sustained drug release behavior and excellent physicochemical stability. Cellular uptake studies demonstrated the specific binding between fucoidan and P-selectin, leading to higher internalization of the micelles, which exhibited ideal kidney-targeted characteristics. In vivo studies showed that the micelles possessed anti-inflammatory and antioxidant abilities, enhancing the therapeutic efficacy of AKI.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Qiyue Tan, Yuebin Lv, Feng Zhao, Jinhui Zhou, Yang Yang, Yingchun Liu, Mingyuan Zhang, Feng Lu, Yuan Wei, Xin Chen, Ruizhi Zhang, Chen Chen, Bing Wu, Xiaochang Zhang, Chengcheng Li, Hongyuan Huang, Junfang Cai, Zhaojin Cao, Di Yu, John S. Ji, Shuhua Zhao, Xiaoming Shi
Summary: This study found that even low levels of arsenic exposure were associated with an increased risk of oxidative stress, showing a nonlinear dose-response relationship.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Qian Xu, Ying Fu, Jingshu Ji, Xiaoxing Du, Yunsong Yu
Summary: The study revealed the combined effect of aztreonam and amoxicillin/clavulanic acid against carbapenem-resistant Gram-negative pathogens, showing bactericidal effects against infections caused by MBL-producing CR-GNOs.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Oncology
Jinyu Zhu, Bufu Tang, Xiuling Lv, Miaomiao Meng, Qiaoyou Weng, Nannan Zhang, Jie Li, Kai Fan, Liyun Zheng, Shiji Fang, Min Xu, Jiansong Ji
Summary: This study identified two apoptosis genes associated with overall survival in HCC patients based on RNA sequencing data, and constructed prognostic and diagnostic models, showing that the high-risk group had lower OS time and advanced HCC patients had higher risk score and worse prognosis compared to early-stage HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Bufu Tang, Jinyu Zhu, Zhongwei Zhao, Chenying Lu, Siyu Liu, Shiji Fang, Liyun Zheng, Nannan Zhang, Minjiang Chen, Min Xu, Risheng Yu, Jiansong Ji
Summary: In this study, TMB-specific genes with good prognostic value were identified to establish diagnostic and prognostic models for HCC patients. Patients with high prognostic risk showed poorer survival probability and higher infiltration of immune cells, drug resistance, and cell proliferation and migration. These findings provide guidance for treatment strategies and improving outcomes in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Engineering, Environmental
Xiao-Ling Xu, Mei-Xuan Chen, Xue-Fang Lou, Yu-Yin Du, Gao-Feng Shu, Jing Qi, Meng-Lu Zhu, Xiao-Ying Ying, Lian Yu, Jian-Song Ji, Yong-Zhong Du
Summary: A novel sialic acid-PEG-modified mesoporous polydopamine nanoparticle dual loaded with indocyanine green and 3PO (SPMI/3) was fabricated for enhanced PDT therapy through tumor vessel normalization. The specific accumulation of SPMI/3 targeting inflammatory endothelial cells, combined therapy of PDT and photothermal therapy, and slow release of 3PO contributed to improved tumor vasculature, reduced vascular permeability, and decreased tissue hypoxia. These enhancements led to the inhibition of metastasis, providing a promising strategy for PDT therapy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Environmental Sciences
Chengcheng Qiu, John S. Ji, Michelle L. Bell
Summary: The study examined the association between temperature and mortality among older adults in China from 2000 to 2014, and found that higher greenness levels in residential areas were associated with lower mortality risk on extreme hot and cold days. Regional differences were observed in how greenness affected the temperature-mortality relationship.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bufu Tang, Jinyu Zhu, Shiji Fang, Yajie Wang, Rajamanickam Vinothkumar, Mengyao Li, Qiaoyou Weng, Liyun Zheng, Yang Yang, Rongfang Qiu, Min Xu, Zhongwei Zhao, Jiansong Ji
Summary: The study demonstrates that OTSSP167 has a significant effect on inhibiting intestinal inflammation and the occurrence and progression of colitis-associated carcinogenesis, mainly through regulating gut microbial composition, inhibiting ferroptosis, and suppressing inflammatory responses.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yumin Hu, Qiaoyou Weng, Haihong Xia, Tao Chen, Chunli Kong, Weiyue Chen, Peipei Pang, Min Xu, Chenying Lu, Jiansong Ji
Summary: A radiomic nomogram based on CT arterial phase was developed and validated to differentiate primary and secondary ovarian cancers. The nomogram combining radiomic and clinical features showed good discrimination and accuracy in the training cohort, suggesting its potential clinical usefulness in this context.
ABDOMINAL RADIOLOGY
(2021)
Article
Cell Biology
Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao, Jiansong Ji
Summary: The study found that USP9X alleviates the malignant potential of cholangiocarcinoma through upregulation of EGLN3. These findings provide a novel insight into the potential of USP9X as a biomarker or therapeutic/diagnostic target for cholangiocarcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Minjiang Chen, Xiaoling Xu, Gaofeng Shu, Chenying Lu, Jiahui Wu, Xiuling Lv, Jingjing Song, Fazong Wu, Chunmiao Chen, Nannan Zhang, Yuyin Du, Jun Wang, Min Xu, Shiji Fang, Qiaoyou Weng, Yiling Zhu, Yuan Huang, Zhongwei Zhao, Yongzhong Du, Jiansong Ji
Summary: The study introduced NaHCO3 nanoparticles into drug-loaded microspheres to neutralize lactic acid in the tumor microenvironment, leading to improved efficacy in antitumor effects. The dual-loaded microspheres exhibited strong synergistic antitumor effects of embolization, chemotherapy, and tumor microenvironment improvement, showing potential for enhancing chemoembolization treatments for hepatocellular carcinoma and other blood-rich solid tumors in clinical settings.
ACS APPLIED BIO MATERIALS
(2021)