Article
Chemistry, Multidisciplinary
Ananth Kamath, Richard D. Schaller, Philippe Guyot-Sionnest
Summary: In this work, HgSe/CdSe core/shell quantum dots (QDs) emitting at 1.7 μm were synthesized with a thick shell to increase the photoluminescence quantum yield. The quantum yield was measured to be 63% in nonpolar solvents, indicating the potential for even higher quantum yield when solubilized in water. Our findings highlight the importance of a thick type-I shell for achieving bright emission in the NIR-IIb region.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Shan He, Jun Du, Wenfei Liang, Boyu Zhang, Guijie Liang, Kaifeng Wu
Summary: Thermally activated delayed photoluminescence (TADPL) is an exotic mechanism observed in molecule-functionalized semiconductor nanocrystals, which allows for energy harvesting from dark molecular triplets and controllable, long-lived photoluminescence. Despite successful coverage of the visible spectrum, TADPL in nanocrystals is less efficient compared to thermally activated delayed fluorescence (TADF) molecules. In this study, bright, near-infrared TADPL was achieved in lead-free CuInSe2 nanocrystals functionalized with carboxylated tetracene ligands, by efficient triplet energy transfer from nanocrystals to ligands and subsequent thermally activated reverse energy transfer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Baisong Chang, Hao Zhu, Yifan Wu, Shaolong Wu, Liqin Zhang, Chunrong Qu, Ying Ren, Zhen Cheng
Summary: The study introduces a novel strategy for selective signal activation through aggregation-induced emission-mode-switching, enabling the probe to switch from weak fluorescence to strong NIR-II phosphorescence. This new approach utilizes Copper indium selenium (Cu-In-Se) quantum dots, which exhibit over 2.7 x 10^3-fold increase in luminescent lifetime when aggregated, and shows potential for designing smart NIR-II probes for advanced imaging applications.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Jin Li, Binge Deng, Jian Ye
Summary: Second near-infrared window (NIR-II, 1000-1700 nm) imaging is a promising optical technique, but surface-enhanced Raman scattering (SERS)-based research in this range is limited due to the lack of suitable NIR-II Raman reporters. This study presents the first example of a nickel dithiolene complex as a NIR-II resonance Raman reporter, which exhibits intense long wavelength absorption, fluorescence-free features, and high affinity to noble metal surfaces. The developed NIR-II nanoprobes enable high contrast and highly photostable lymph node imaging, as well as in vivo SERS detection of deep-seated microtumors in mice.
Review
Chemistry, Multidisciplinary
Zi'an Wang, Xuan Wang, Jian-Bo Wan, Fujian Xu, Nana Zhao, Meiwan Chen
Summary: This review summarizes the latest progress of NIR-II optical imaging for angiography, including fluorescence imaging, photoacoustic imaging, and optical coherence tomography. It highlights the optimization and application of probes in vascular imaging.
Article
Chemistry, Multidisciplinary
Dong Wang, Hongzhi Wang, Lei Ji, Meng Xu, Bing Bai, Xiaodong Wan, Dayong Hou, Zeng-Ying Qiao, Hao Wang, Jiatao Zhang
Summary: The study presents a novel nanomaterial ACA that enables multi-intensified antibacterial PDT induced by NIR-II light, with high ROS generation capability and antibacterial efficacy.
Article
Chemistry, Physical
Minghui Jin, Fan Li, Junqing Xiahou, Lin Zhu, Qi Zhu, Ji-Guang Li
Summary: Recently, NIR persistent phosphors have gained attention in biomedical applications due to their low absorption coefficients in biological tissues. In this study, persistent luminescent phosphors of ZnGa2O4:xNi2+ were synthesized, which emit broad NIR emission in the second near-infrared (NIR-II) window. The phosphors exhibit long-lasting afterglow and strong NIR emission, making them potential candidates for in vivo imaging.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Review
Chemistry, Multidisciplinary
Ke Zhang, Fu-Rong Chen, Lidai Wang, Jinlian Hu
Summary: In this review, the advantages and various imaging technologies of near-infrared-II (NIR-II) bioimaging for deep brain imaging are discussed, along with the corresponding contrast agents. The applications of NIR-II bioimaging in visualizing cerebrovascular characteristics and monitoring pathology signals, as well as its potential for modulating brain structure and function, are outlined. Future perspectives for improving the clinical translation of NIR-II light are also proposed.
Review
Pharmacology & Pharmacy
Baisong Chang, Jie Chen, Jiasheng Bao, Kangfeng Dong, Si Chen, Zhen Cheng
Summary: In recent years, advances in synthesis chemistries and imaging instruments have led to significant progress in optical bioimaging in the second near-infrared window (NIR-II), benefiting large-scale biomedical applications. However, most NIR-II probes suffer from high background noise, leading to weak detection precision. Therefore, developing NIR-II optical probes that can efficiently activate their luminescent signal and suppress background interference has become a promising research frontier.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Yanling Yang, Yang Xie, Fan Zhang
Summary: In vivo multiplexed bioimaging in the second near-infrared window (NIR-II) has become a growing technology in medical diagnosis and clinical applications due to its advantages of multi-color observations, high sensitivity, deeper penetration, high spatiotemporal resolution, and high throughput. Various types of nanoprobes, including quantum dots, lanthanide downconversion nanoparticles, and organic fluorophores, have shown great potential for intravital imaging and disease diagnosis. This review summarizes recent advances in NIR-II-emitted nanoprobes for intravital multiplexed bioimaging and discusses the challenges and opportunities in designing novel long-wavelength nanoprobes for deep-tissue imaging.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Engineering, Chemical
Dingyuan Yan, Yi Qin, Saisai Yan, Panpan Sun, Yuanwei Wang, Dong Wang, Ben Zhong Tang
Summary: The recent advances in near-infrared emissive aggregation-induced emission nanoparticles (NPs) have shown great potential in biomedical applications. This review summarizes the progress in this field from the perspectives of different fabrication methods, including self-assembly and matrices assisted approaches, and discusses the current challenges and future research directions of near-infrared emissive aggregation-induced emission NPs.
Review
Radiology, Nuclear Medicine & Medical Imaging
Yanling Yang, Fan Zhang
Summary: This systematic review provides an overview of the developments in fluorescence and chemi/bioluminescence imaging based on molecular fluorophores in the second near-infrared (NIR-II) window for in vivo imaging. The review discusses the chemical and optical properties of NIR-II dyes, outlines the bioimaging based on NIR-II fluorescence emission, demonstrates the chemi/bioluminescence imaging in the second NIR window, presents the clinical application and translation of near-infrared fluorescence imaging, and discusses the current challenges, strategies, and prospects of fluorophores and in vivo bioimaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Savas Delikanli, Furkan Isik, Emek G. Durmusoglu, Onur Erdem, Farzan Shabani, Betul Canimkurbey, Satish Kumar, Hamed Dehghanpour Baruj, Hilmi Volkan Demir
Summary: This study demonstrates the achievement of optical gain in an aqueous medium using specially designed heterostructured quantum wells, opening up possibilities for bio-optoelectronic applications.
Article
Nanoscience & Nanotechnology
Yiwei Yang, Ying Chen, Peng Pei, Yong Fan, Shangfeng Wang, Hongxin Zhang, Dongyuan Zhao, Bin-Zhi Qian, Fan Zhang
Summary: This study presents a novel optical imaging strategy using thulium-based nanoparticles to amplify fluorescence signals at 1,632 nm, enabling real-time multiplexed imaging of cerebrovascular vasomotion activity and single neutrophil behavior in mouse subcutaneous tissue.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hongchao Yang, Renfu Li, Yejun Zhang, Mengxuan Yu, Zan Wang, Xi Liu, Wenwu You, Datao Tu, Ziqiang Sun, Rong Zhang, Xueyuan Chen, Qiangbin Wang
Summary: Alloyed AgAuSe quantum dots exhibit high PLQY and long lifetime in the NIR-II window, showing great potential for applications in bioimaging, LEDs, and photovoltaic devices.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Qiushu Du, Wenqi Wang, Xianghua Zeng, Xiliang Luo
Summary: An electrochemical biosensor based on an antifouling zwitterionic peptide hydrogel and poly (3,4-ethylenedioxythiophene) (PEDOT) was developed for accurate detection of prostate specific antigen (PSA) in complex human serum. The antifouling properties of the peptide hydrogel prevented nonspecific adsorption of proteins, cells, and other biomolecules, making it suitable for biosensing applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xiqin Yang, Min Chen, Zhanhua Zhang, Yang Li, Peipei Wang, Xiliang Luo, Shaoping Lv
Summary: This study proposes an effective strategy to construct low fouling electrochemical biosensors based on specially designed Aib-peptides. These Aib-peptides exhibit excellent antifouling properties and enhanced stability, enabling accurate and reliable detection of IgG in clinical human sera.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xuanhao Zhang, Qian Li, Qiqi Chao, Yuxi Zhang, Xufeng Sun, Gao-Chao Fan, Zhi Ling Song, Rongmei Kong, Xiliang Luo
Summary: In this study, a protein enzyme-free and general approach for sensitive detection of single nucleotide polymorphisms (SNPs) is developed using asymmetric MNAzyme probes. The multi-arm probe (MNAzyme-9M-13) with two asymmetric recognition arms is designed to detect EGFR T790 M mutation. Through a one-pot mixing, the probe enables the sensitive detection of the mutation without protein enzyme or multi-step operation. The strategy also shows potential for SNPs detection in long genomic sequences and short microRNAs.
ANALYTICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Nianzu Liu, Yihui Ma, Zhenying Xu, Yingshu Guo, Xiliang Luo
Summary: We report a PANI-HA hydrogel that combines rigid conducting polymer with flexible HA. The supramolecular assembly of PANI and HA via boronic acid bonds yields PANI-HA hydrogel with unique microstructure, electrical conductivity and hydrophilicity, showing excellent supercapacitor performance and electrochemical sensing for IgG. The PANI-HA hydrogel-based electrode exhibits high specific capacitance (369 F g(-1)) and good cycling stability (85% capacity retention after 1000 charge-discharge cycles). It can also be used as an electrochemical biosensor for IgG detection with good sensitivity, wide detection range, and low detection limit.
JOURNAL OF MATERIALS SCIENCE
(2023)
Editorial Material
Chemistry, Analytical
Xiliang Luo
Article
Chemistry, Multidisciplinary
Sai Zhang, Ping Chen, Yu Fan, Yan Zhao, Wenlong Yang, Hongtao Gao, Xiliang Luo
Summary: This study successfully synthesized amorphous and crystalline NiS2 nanospheres using a simple method and found that the amorphous structure of NiS2 catalyst has superior electrochemical activity for methanol oxidation reaction compared to the crystalline counterpart.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lei Zhang, Han Liu, Qianyao Du, Guoqiang Zhang, Shanhui Zhu, Zhongtao Wu, Xiliang Luo
Summary: Photoresponsive phase change materials have the ability to store and release both photon and heat energy. By designing azobenzene surfactants at the molecular level, it is possible to achieve high gravimetric energy density and enhance molar isomerization enthalpy.
Article
Chemistry, Analytical
Xiao-Long Zhang, Sha-Sha Li, Yi-Jia Liu, Wei-Wei Liu, Ling-Qi Kong, Ya-Qin Chai, Xi-Liang Luo, Ruo Yuan
Summary: An ingenious three-dimensional DNA walker with high walking efficiency is developed by limiting the reaction space, providing a rapid and sensitive detection method for miRNA. Compared to traditional DNA walkers, this immobilized DNA walker shows improved kinetic and thermodynamic favorability, resulting in faster reaction speed and higher walking efficiency. By utilizing this walker, a sensitive sensing platform for rapid miRNA-21 detection is constructed with a limit of detection of 19.8 aM, allowing for highly sensitive biomarker detection in cancer cell lysates.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Yanxin Li, Shuju Zhao, Zhenying Xu, Xiujuan Qiao, Mingxuan Li, Youke Li, Xiliang Luo
Summary: A non-fouling electrochemical biosensor was constructed using antifouling peptides and electroneutral PNA as the recognizing probe for SARS-CoV-2 viral RNA. The biosensor exhibited remarkable sensitivity with a broad linear range (1.0 fM -1.0 nM) and a low detection limit of 0.38 fM. This study provided a new strategy for developing non-fouling sensing systems capable of detecting trace disease biomarkers in complex biological media.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Zhen Song, Rong Li, Xiqin Yang, Adriano Ambrosi, Xiliang Luo
Summary: This paper presents a simple one-step assembly method for constructing phase-transited bovine serum albumin antifouling layers, which are used for the development of antifouling electrochemical sensors. These sensors can accurately and sensitively detect uric acid in human body fluids.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Shuju Zhao, Zhen Song, Tao Liu, Xin Wang, Yanxin Li, Yaqun Xu, Hao Wang, Yumin Wu, Xiliang Luo
Summary: Zwitterionic peptides with strong water binding ability have been designed to construct antifouling biosensors with enhanced stability in complex biological fluids. The designed peptides demonstrated much stronger antifouling capability and significantly enhanced stability in human serum and blood. Furthermore, the biosensor integrating the designed antifouling peptide with CEA aptamer exhibited a great sensitivity for detecting CEA protein, making it promising for practical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Nianzu Liu, Ruoxing Wang, Shengjie Gao, Ruifang Zhang, Fengru Fan, Yihui Ma, Xiliang Luo, Dong Ding, Wenzhuo Wu
Summary: Leveraging mechanically-induced piezoelectric polarization, piezocatalysis emerges as a viable mechanism for enhancing catalytic processes. Nanostructured, catalytically active, rationally designed piezo-electric semiconductors can achieve high-performance catalysts for various applications using cost-effective electrocatalytic pathways, such as mechanical stimuli. The facile synthesis of high-quality ZnO nanostructures enables low-cost, scalable manufacture and direct integration into electrocatalysts for enhanced performance.
Article
Chemistry, Analytical
Fu-Hui Lyu, Chen-Chen Li, Yue Li, Lin Cui, Xi-Liang Luo
Summary: Metal-organic gels (MOGs) are gel materials formed by bridging metal ions and organic ligands via non covalent interactions. They have advantages such as easy preparation, large specific surface area, tunable structure, and abundant metal sites, making them widely used in sensing, analysis, catalysis, adsorption, energy storage and electrochromic devices. This paper reviews the progress in the research and application of MOGs in these fields, and discusses the challenges, future trends and application prospects.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tingting Zhao, Jiaheng Shi, Junhao Wang, Yanyun Cui, Yifan Yang, Shenghao Xu, Xiliang Luo
Summary: A DNA sensing platform with endogenous stimuli-responsive and ultrasensitive characteristics, incorporating a logic gate biocomputation, has been developed for precise cell subtype identification in disease diagnosis and prognostic estimation.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Rui Han, Wenjie Hou, Yang Li, Min Chen, Caifeng Ding, Xiliang Luo
Summary: A sensitive electrochemical biosensor based on a self-designed cyclic peptide is capable of detecting the RBD antigen in human blood. The cyclic peptide possesses excellent antifouling properties and strong anti-enzymatic hydrolysis ability, making the biosensor stable and reliable for COVID-19 antigen testing.
SENSORS & DIAGNOSTICS
(2023)
