CRISPR-based functional genomics in human dendritic cells

Dendritic Cell Subsets in Intestinal Immunity and Inflammation

(2020) Tian Sun et al.   JOURNAL OF IMMUNOLOGY

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9

(2020) Emily C. Freund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

(2020) Luke Riggan et al.   Cell Reports

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Pairing Bacteroides vulgatus LPS Structure with Its Immunomodulatory Effects on Human Cellular Models

(2020) Flaviana Di Lorenzo et al.   ACS Central Science

COVID-19

(2020) Naveen L. Pereira et al.   MAYO CLINIC PROCEEDINGS

SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity

(2020) Sofía C. Khouili et al.   Cell Reports

Weak agonistic LPS restores intestinal immune homeostasis

(2019) Alex Steimle et al.   MOLECULAR THERAPY

Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells

(2019) Ryan T. Leenay et al.   NATURE BIOTECHNOLOGY

Biological plasticity rescues target activity in CRISPR knock outs

(2019) Arne H. Smits et al.   NATURE METHODS

Genetic and evolutionary determinants of human population variation in immune responses

(2018) Joaquin Sanz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron

(2018) Amy N. Jacobson et al.   mBio

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

(2018) A. Laustsen et al.   Nature Communications

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells

(2018) Pamela Y. Ting et al.   NATURE METHODS

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

(2017) Abhishek D. Garg et al.   TRENDS IN IMMUNOLOGY

An insider's perspective: Bacteroides as a window into the microbiome

(2017) Aaron G. Wexler et al.   Nature Microbiology

Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling

(2017) Eva d’Hennezel et al.   mSystems

Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data

(2016) Joshua G. Dunn et al.   BMC GENOMICS

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation

(2016) Yuanyuan Ding et al.   NATURE IMMUNOLOGY

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

(2015) Yunhao Tan et al.   IMMUNITY

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

(2015) T. W. Cullen et al.   SCIENCE

Intersection of population variation and autoimmunity genetics in human T cell activation

(2014) C. J. Ye et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Dynamic responses ofBacteroides thetaiotaomicronduring growth on glycan mixtures

(2013) Theresa E. Rogers et al.   MOLECULAR MICROBIOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Use and Abuse of RNAi to Study Mammalian Gene Function

(2012) W. G. Kaelin   SCIENCE

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

The Lipid A Phosphate Position Determines Differential Host Toll-Like Receptor 4 Responses to Phylogenetically Related Symbiotic and Pathogenic Bacteria

(2010) Stephen R. Coats et al.   INFECTION AND IMMUNITY