Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice

(2020) Liliane Khoryati et al.   Science Immunology

Structural Basis of Partial Agonism at the β2-Adrenergic Receptor

(2019) Arun K. Shukla   BIOCHEMISTRY

Structure of the IFNγ receptor complex guides design of biased agonists

(2019) Juan L. Mendoza et al.   NATURE

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Synthetic cytokine receptors transmit biological signals using artificial ligands

(2018) Erika Engelowski et al.   Nature Communications

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

(2018) Laurence B. Peterson et al.   JOURNAL OF AUTOIMMUNITY

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

(2017) Byron B. Au-Yeung et al.   JOURNAL OF IMMUNOLOGY

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

(2017) Jian-Xin Lin et al.   Nature Communications

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes

(2016) Cherie T. Ng et al.   CELL

Constitutive Lck Activity Drives Sensitivity Differences between CD8+Memory T Cell Subsets

(2016) Duane Moogk et al.   JOURNAL OF IMMUNOLOGY

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

(2016) Tilman Schlothauer et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

(2016) Alejandro Villarino et al.   eLife

Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes

(2016) Minh N. Pham et al.   Frontiers in Immunology

Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection

(2015) Cherie T. Ng et al.   Cell Host & Microbe

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

(2015) Li-Fan Lu et al.   IMMUNITY

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Dynamic Submicroscopic Signaling Zones Revealed by Pair Correlation Tracking and Localization Microscopy

(2014) Changjiang You et al.   ANALYTICAL CHEMISTRY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

IL-2 Produced by CD8+ Immune T Cells Can Augment Their IFN-  Production Independently from Their Proliferation in the Secondary Response to an Intracellular Pathogen

(2013) Q. Sa et al.   JOURNAL OF IMMUNOLOGY

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis

(2009) K Weber et al.   GENE THERAPY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

(2008) Jan Vogelsang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS